There are 4 ways to get from Charleston to Key West by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h 27 min

  1. Fly from Charleston (CHS) to Key West (EYW) CHS - EYW

$237 - $1,029

Cheapest option

Bus  •  21 h 53 min

  1. Take the bus from Charleston, SC to Savannah, GA
  2. Take the bus from Savannah, Ga to Miami, Fl
  3. Take the bus from Miami, Fl to Key West, Fl

$96 - $222

2 alternative options

Drive, train, bus  •  20 h 55 min

  1. Drive from Charleston to Yemassee Amtrak
  2. Take the train from Yemassee Amtrak to Hollywood Amtrak
  3. Take the bus from Miami, Fl to Key West, Fl

$117 - $308

Drive  •  13 h 14 min

  1. Drive from Charleston to Key West 746.3 miles

$70 - $110

Questions & Answers

The cheapest way to get from Charleston to Key West is to drive which costs $70 - $110 and takes 13 h 14 min.

More details

The quickest way to get from Charleston to Key West is to fly which costs $230 - $1,100 and takes 6 h 27 min.

More details

The distance between Charleston and Key West is 582 miles. The road distance is 746.3 miles.

Get driving directions

It takes approximately 6 h 27 min to get from Charleston to Key West, including transfers.

More details

No, there is no direct bus from Charleston to Key West. However, there are services departing from Mary St / Meeting St and arriving at Flagler & Grinnell via Charleston, SC, Savannah, Ga, Miami, Fl and Airport/Beaches. The journey, including transfers, takes approximately 21 h 53 min.

More details

What companies run services between Charleston, SC, USA and Key West, FL, USA?

Delta, American Airlines and three other airlines fly from Charleston to Key West hourly. Alternatively, you can take a bus from Charleston to Key West via N. Charleston SuperStop on Rivers Ave, Charleston, SC, Savannah, GA, Savannah, Ga, Miami, Fl, Key West, Fl, and Airport/Beaches in around 21 h 53 min.

Airlines
American Airlines
Website
aa.com
Flights from Charleston to Key West via Miami
Ave. Duration
5 h 14 min
When
Every day
Estimated price
$230 - $1,100
Flights from Charleston to Key West via Reagan Washington
Ave. Duration
5 h 25 min
When
Sunday
Estimated price
$310 - $1,300
Flights from Charleston to Key West via Charlotte
Ave. Duration
6 h 26 min
When
Every day
Estimated price
$260 - $1,200
Flights from Charleston to Key West via Charlotte, Miami
Ave. Duration
7 h 6 min
When
Every day
Estimated price
$260 - $1,200
Delta
Website
delta.com
Flights from Charleston to Key West via Atlanta
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$240 - $1,200
JetBlue Airways
Website
jetblue.com
Flights from Charleston to Key West via Fort Lauderdale
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$210 - $1,000
United Airlines
Website
united.com
Flights from Charleston to Key West via Chicago O'Hare
Ave. Duration
8 h 1 min
When
Saturday and Sunday
Estimated price
$360 - $1,500
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Yemassee Amtrak to Hollywood Amtrak
Ave. Duration
12 h 16 min
Frequency
Once daily
Estimated price
$85 - $240
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $220
Business Coach Seat
$170 - $240
Room
$360 - $500
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Miami, Fl to Key West, Fl
Ave. Duration
4 h 30 min
Frequency
Hourly
Estimated price
$21 - $50
Website
greyhound.com
Economy
$21 - $35
Flexible
$35 - $50
Bus from Savannah, Ga to Miami, Fl
Ave. Duration
11 h 30 min
Frequency
Every 30 minutes
Estimated price
$50 - $130
Website
greyhound.com
Economy
$50 - $85
Flexible
$100 - $130

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