There are 4 ways to get from Charleston to Key West by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h 44 min

  1. Fly from Charleston (CHS) to Key West (EYW) CHS - EYW

$237 - $1,029

Cheapest option

Bus  •  22 h 8 min

  1. Take the bus from Charleston, SC to Savannah
  2. Take the bus from Savannah, Ga to Miami, Fl
  3. Take the bus from Miami, Fl to Big Pine Key
  4. Take the bus from Lower Keys Shuttle to Key West, FL - Northside & 5th St.

$94 - $217

2 alternative options

Drive, train, bus  •  21 h 10 min

  1. Drive from Charleston to Yemassee Amtrak
  2. Take the train from Yemassee Amtrak to Hollywood Amtrak
  3. Take the bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum 400

$126 - $321

Drive  •  13 h 14 min

  1. Drive from Charleston to Key West 746.3 miles

$70 - $110

Questions & Answers

No, there is no direct bus from Charleston to Key West. However, there are services departing from Mary St / Meeting St and arriving at Key West, FL - Northside & 5th St. via Charleston, SC, Savannah, Ga, Miami, Fl and Lower Keys Shuttle. The journey, including transfers, takes approximately 22 h 8 min.

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The distance between Charleston and Key West is 582 miles. The road distance is 746.3 miles.

Get driving directions

The best way to get from Charleston to Key West without a car is to bus which takes 22 h 8 min and costs .

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It takes approximately 6 h 44 min to get from Charleston to Key West, including transfers.

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Charleston to Key West bus services, operated by South Eastern Stages, depart from Charleston, SC station.

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The best way to get from Charleston to Key West is to fly which takes 6 h 44 min and costs . Alternatively, you can bus, which costs and takes 22 h 8 min.

Mode details

There is no direct flight from Charleston Airport to Key West Airport. The quickest flight takes 4 h 5 min and has one stopover.

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Charleston to Key West bus services, operated by Key West Transit, arrive at Key West, FL - Northside & 5th St. station.

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Yes, the driving distance between Charleston to Key West is 746 miles. It takes approximately 13 h 14 min to drive from Charleston to Key West.

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JetBlue Airways, Silver Airways, United Airlines and two other airlines offer flights from Charleston Airport to Key West Airport.

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Map of how to get from Charleston to Key West.
Launch map view
  • Distance: 582.4 miles
  • Duration: 6 h 44 min

What companies run services between Charleston, SC, USA and Key West, FL, USA?

American Airlines, Delta and three other airlines fly from Charleston to Key West hourly. Alternatively, you can take a bus from Charleston to Key West via Dorchester Rd / Allen, Charleston, SC, Savannah, Savannah, Ga, Miami, Fl, Big Pine Key, and Lower Keys Shuttle in around 22 h 8 min.

Airlines
American Airlines
Website
aa.com
Flights from Charleston to Key West via Miami
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$230 - $1,100
Flights from Charleston to Key West via Charlotte
Ave. Duration
4 h 42 min
When
Every day
Estimated price
$260 - $1,200
Flights from Charleston to Key West via Philadelphia
Ave. Duration
7 h 52 min
When
Saturday
Estimated price
$330 - $1,300
Flights from Charleston to Key West via Charlotte, Miami
Ave. Duration
7 h 14 min
When
Every day
Estimated price
$260 - $1,200
Delta
Website
delta.com
Flights from Charleston to Key West via Atlanta
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$240 - $1,200
JetBlue Airways
Website
jetblue.com
Flights from Charleston to Key West via Fort Lauderdale
Ave. Duration
5 h 4 min
When
Wednesday
Estimated price
$210 - $1,000
United Airlines
Website
united.com
Flights from Charleston to Key West via Chicago O'Hare
Ave. Duration
8 h 10 min
When
Sunday
Estimated price
$360 - $1,500
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Yemassee Amtrak to Hollywood Amtrak
Ave. Duration
12 h 16 min
Frequency
Once daily
Estimated price
$85 - $240
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $220
Business Coach Seat
$170 - $240
Room
$360 - $500
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Miami, FL - Airport Regency Hotel to Key West, FL - Mel Fisher Museum
Ave. Duration
4 h
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Savannah, Ga to Miami, Fl
Ave. Duration
11 h 30 min
Frequency
Every 30 minutes
Estimated price
$50 - $130
Website
greyhound.com
Economy
$50 - $85
Flexible
$100 - $130
Bus from Miami, Fl to Big Pine Key
Ave. Duration
3 h 35 min
Frequency
Hourly
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$30 - $45
Key West Transit
Phone
(305) 600-1455
Website
kwtransit.com
Bus from Lower Keys Shuttle to Key West, FL - Northside & 5th St.
Ave. Duration
59 min
Frequency
Every 4 hours
Estimated price
$2 - $4
Schedules at
cityofkeywest-fl.gov

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More Questions & Answers

There are 328+ hotels available in Key West. Prices start at $129 USD per night.

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The best way to get from Charleston to Charleston Airport is to Shuttle Bus which takes 30 min and costs .

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