There are 4 ways to get from Charleston to Great Smoky Mountains National Park by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, drive  •  13 h 53 min

  1. Take the bus from Charleston to Columbia, SC
  2. Take the bus from Columbia, Sc to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains National Park

$72 - $151

3 alternative options

Drive  •  5 h 29 min

  1. Drive from Charleston to Great Smoky Mountains National Park 332.9 miles

$30 - $50

Fly from Charleston, drive  •  6 h 15 min

  1. Fly from Charleston (CHS) to Knoxville (TYS) CHS - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$180 - $884

Drive to Hilton Head, fly, drive  •  7 h 57 min

  1. Drive from Charleston to Hilton Head
  2. Fly from Hilton Head (HHH) to Knoxville (TYS) HHH - TYS
  3. Drive from Knoxville to Great Smoky Mountains National Park

$125 - $624

Questions & Answers

The cheapest way to get from Charleston to Great Smoky Mountains National Park is to drive which costs $30 - $50 and takes 5 h 29 min.

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The quickest way to get from Charleston to Great Smoky Mountains National Park is to drive which costs $30 - $50 and takes 5 h 29 min.

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The distance between Charleston and Great Smoky Mountains National Park is 284 miles. The road distance is 332.9 miles.

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It takes approximately 13 h 53 min to get from Charleston to Great Smoky Mountains National Park, including transfers.

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There is no direct flight from Charleston Airport to Knoxville Airport. The quickest flight takes 3 h 8 min and has one stopover.

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Yes, the driving distance between Charleston to Great Smoky Mountains National Park is 333 miles. It takes approximately 5 h 29 min to drive from Charleston to Great Smoky Mountains National Park.

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United Airlines, American Airlines and Delta offer flights from Charleston Airport to Knoxville Airport.

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There are 1536+ hotels available in Great Smoky Mountains National Park. Prices start at $69 USD per night.

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Map of how to get from Charleston to Great Smoky Mountains National Park.
Launch map view
  • Distance: 284.3 miles
  • Duration: 13 h 53 min

What companies run services between Charleston, SC, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Charleston to Great Smoky Mountains National Park. However, you can take the bus to Columbia, SC, take the walk to Columbia, Sc, take the bus to Winston Salem, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the drive to Great Smoky Mountains National Park.

Airlines
American Airlines
Website
aa.com
Flights from Charleston to Knoxville via Charlotte
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$160 - $850
Flights from Charleston to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 55 min
When
Every day
Estimated price
$270 - $1,100
Flights from Charleston to Knoxville via Reagan Washington
Ave. Duration
6 h 6 min
When
Every day
Estimated price
$200 - $900
Flights from Charleston to Knoxville via Philadelphia
Ave. Duration
6 h 26 min
When
Monday, Thursday, Friday and Sunday
Estimated price
$220 - $950
Flights from Charleston to Knoxville via Miami
Ave. Duration
6 h 29 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$220 - $950
Flights from Hilton Head to Knoxville via Charlotte
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$110 - $600
Flights from Hilton Head to Knoxville via Charlotte, Reagan Washington
Ave. Duration
6 h 50 min
When
Every day
Estimated price
$140 - $650
Flights from Hilton Head to Knoxville via Charlotte, Philadelphia
Ave. Duration
6 h 52 min
When
Saturday
Estimated price
$160 - $700
Flights from Hilton Head to Knoxville via Charlotte, Chicago O'Hare
Ave. Duration
8 h 23 min
When
Every day
Estimated price
$160 - $700
Flights from Hilton Head to Knoxville via Charlotte, Dallas/Ft.Worth
Ave. Duration
8 h 24 min
When
Every day
Estimated price
$190 - $750
Delta
Website
delta.com
Flights from Charleston to Knoxville via Atlanta
Ave. Duration
3 h 28 min
When
Every day
Estimated price
$150 - $850
Flights from Charleston to Knoxville via Detroit
Ave. Duration
5 h 44 min
When
Every day
Estimated price
$200 - $950
United Airlines
Website
united.com
Flights from Charleston to Knoxville via Washington Dulles
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$210 - $950
Flights from Charleston to Knoxville via Chicago O'Hare
Ave. Duration
5 h 9 min
When
Every day
Estimated price
$230 - $1,100
Flights from Charleston to Knoxville via Houston
Ave. Duration
5 h 52 min
When
Every day
Estimated price
$260 - $1,200
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbia, Sc to Winston Salem, Nc
Ave. Duration
5 h 5 min
Frequency
Hourly
Estimated price
$21 - $55
Website
greyhound.com
Economy
$21 - $35
Flexible
$40 - $55
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50

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Trips to Great Smoky Mountains National Park