There are 5 ways to get from Charleston to Gainesville by bus, car, train or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, Megabus  •  12 h 51 min

  1. Take the bus from Charleston, SC to Savannah
  2. Take the bus from Savannah, Ga to Jacksonville, Fl
  3. Take the Megabus from Jacksonville to Orlando
  4. Take the Megabus from Orlando to Gainesville

$70 - $132

Cheapest option

Drive, train  •  6 h 14 min

  1. Drive from Charleston to Yemassee Amtrak
  2. Take the train from Yemassee Amtrak to Jacksonville Amtrak
  3. Drive from Jacksonville Amtrak to Gainesville

$52 - $119

3 alternative options

Drive  •  5 h 30 min

  1. Drive from Charleston to Gainesville 308.9 miles

$30 - $45

Fly to Gainesville  •  6 h 6 min

  1. Fly from Charleston (CHS) to Gainesville (GNV) CHS - GNV

$237 - $1,127

Fly to Valdosta, bus  •  7 h 28 min

  1. Fly from Charleston (CHS) to Valdosta (VLD) CHS - VLD
  2. Take the bus from Valdosta, GA to Gainesville, FL

$409 - $1,114

Questions & Answers

No, there is no direct bus from Charleston to Gainesville. However, there are services departing from Mary St / Meeting St and arriving at Gainesville via Charleston, SC, Savannah, Ga, Jacksonville and Orlando. The journey, including transfers, takes approximately 12 h 51 min.

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The distance between Charleston and Gainesville is 260 miles. The road distance is 308.9 miles.

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The best way to get from Charleston to Gainesville without a car is to bus and Megabus which takes 12 h 51 min and costs .

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It takes approximately 12 h 51 min to get from Charleston to Gainesville, including transfers.

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Charleston to Gainesville bus services, operated by South Eastern Stages, depart from Charleston, SC station.

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The best way to get from Charleston to Gainesville is to bus and Megabus which takes 12 h 51 min and costs . Alternatively, you can fly, which costs and takes 6 h 6 min.

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There is no direct flight from Charleston Airport to Gainesville Airport. The quickest flight takes 3 h 22 min and has one stopover.

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Charleston to Gainesville bus services, operated by Megabus, arrive at Gainesville station.

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Yes, the driving distance between Charleston to Gainesville is 309 miles. It takes approximately 5 h 30 min to drive from Charleston to Gainesville.

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American Airlines and Delta offer flights from Charleston Airport to Gainesville Airport.

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Map of how to get from Charleston to Gainesville.
Launch map view
  • Distance: 259.6 miles
  • Duration: 12 h 51 min

What companies run services between Charleston, SC, USA and Gainesville, FL, USA?

You can take a bus from Charleston to Gainesville via Dorchester Rd / Allen, Charleston, SC, Savannah, Savannah, Ga, Jacksonville, Fl, Jacksonville, and Orlando in around 12 h 51 min. Alternatively, American Airlines and Delta fly from Charleston to Gainesville hourly.

Airlines
Delta
Website
delta.com
Flights from Charleston to Gainesville via Atlanta
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$210 - $1,100
Flights from Charleston to Valdosta via Atlanta
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$160 - $850
American Airlines
Website
aa.com
Flights from Charleston to Gainesville via Charlotte
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$230 - $1,200
Flights from Charleston to Gainesville via Miami
Ave. Duration
4 h 27 min
When
Friday and Sunday
Estimated price
$250 - $1,200
Flights from Charleston to Gainesville via Reagan Washington, Charlotte
Ave. Duration
6 h 59 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,300
Flights from Charleston to Gainesville via Charlotte, Miami
Ave. Duration
7 h 11 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,300
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Yemassee Amtrak to Jacksonville Amtrak
Ave. Duration
3 h 26 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Savannah, Ga to Jacksonville, Fl
Ave. Duration
2 h 15 min
Frequency
Every 10 minutes
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$35 - $45
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Jacksonville to Orlando
Ave. Duration
2 h 30 min
Frequency
Twice daily
Estimated price
$15 - $26
Book at
megabus.com
Bus from Orlando to Gainesville
Ave. Duration
2 h
Frequency
Once daily
Estimated price
$13 - $23
Book at
megabus.com
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Valdosta, GA to Gainesville, FL
Ave. Duration
1 h 27 min
Frequency
3 times a week
Estimated price
$159
Schedules at
lacubanabus.com

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More Questions & Answers

There are 49+ hotels available in Gainesville. Prices start at $64 USD per night.

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The best way to get from Charleston to Charleston Airport is to Shuttle Bus which takes 30 min and costs .

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