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There are 6 ways to get from Charleston to Gainesville by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, Megabus  •  13h 17m

  1. Take the bus from Charleston, SC to Savannah
  2. Take the bus from Savannah, Ga to Jacksonville, Fl
  3. Take the Megabus from Jacksonville to Orlando
  4. Take the Megabus from Orlando to Gainesville

$70 - $132

Cheapest option

Drive, train  •  6h 14m

  1. Drive from Charleston to Yemassee Amtrak
  2. Take the train from Yemassee Amtrak to Jacksonville Amtrak Station
  3. Drive from Jacksonville Amtrak Station to Gainesville

$52 - $119

4 alternative options

Bus, train  •  18h 8m

  1. Take the bus from Charleston, SC to Savannah
  2. Take the train from Savannah Amtrak Station to Tampa Union Station
  3. Take the bus from Tampa Downtown to Gainesville - UF

$122 - $268

Drive  •  5h 30m

  1. Drive from Charleston to Gainesville 308.9 miles

$30 - $45

Fly to Gainesville  •  6h 11m

  1. Fly from Charleston (CHS) to Gainesville (GNV) CHS - GNV

$237 - $1,127

Fly to Valdosta, bus  •  7h 47m

  1. Fly from Charleston (CHS) to Valdosta (VLD) CHS - VLD
  2. Take the bus from Valdosta, GA to Gainesville, FL

$409 - $1,114

Questions & Answers

The cheapest way to get from Charleston to Gainesville is to drive which costs $30 - $45 and takes 5h 30m.

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The quickest way to get from Charleston to Gainesville is to drive which costs $30 - $45 and takes 5h 30m.

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No, there is no direct bus from Charleston to Gainesville. However, there are services departing from Mary St / Meeting St and arriving at Gainesville via Charleston, SC, Savannah, Ga, Jacksonville and Orlando. The journey, including transfers, takes approximately 13h 17m.

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The distance between Charleston and Gainesville is 260 miles. The road distance is 308.9 miles.

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The best way to get from Charleston to Gainesville without a car is to bus and Megabus which takes 13h 17m and costs $70 - $140.

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It takes approximately 13h 17m to get from Charleston to Gainesville, including transfers.

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Charleston to Gainesville bus services, operated by South Eastern Stages, depart from Charleston, SC station.

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The best way to get from Charleston to Gainesville is to bus and Megabus which takes 13h 17m and costs $70 - $140. Alternatively, you can fly, which costs $230 - $1,200 and takes 6h 11m.

Mode details

There is no direct flight from Charleston Airport to Gainesville Airport. The quickest flight takes 3h 27m and has one stopover.

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Charleston to Gainesville bus services, operated by Megabus, arrive at Gainesville station.

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Map of how to get from Charleston to Gainesville.
Launch map view
  • Distance: 259.6 miles
  • Duration: 13h 17m

What companies run services between Charleston, SC, USA and Gainesville, FL, USA?

You can take a bus from Charleston to Gainesville via Charleston, SC, Savannah, Savannah, Ga, Jacksonville, Fl, Jacksonville, and Orlando in around 13h 17m. Alternatively, Delta and American Airlines fly from Charleston to Gainesville hourly.

Airlines
Delta
Website
delta.com
Flights from Charleston to Gainesville via Atlanta
Ave. Duration
4h 5m
When
Every day
Estimated price
$210 - $1,100
Flights from Charleston to Valdosta via Atlanta
Ave. Duration
3h 57m
When
Every day
Estimated price
$160 - $850
American Airlines
Website
aa.com
Flights from Charleston to Gainesville via Charlotte
Ave. Duration
4h 1m
When
Every day
Estimated price
$230 - $1,200
Flights from Charleston to Gainesville via Miami
Ave. Duration
4h 33m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Savannah Amtrak Station to Tampa Union Station
Ave. Duration
8h 5m
Frequency
Once daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $160
Business Coach Seat
$120 - $170
Room
$270 - $380
Train from Yemassee Amtrak to Jacksonville Amtrak Station
Ave. Duration
3h 26m
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Savannah, Ga to Jacksonville, Fl
Ave. Duration
2h 15m
Frequency
Hourly
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$35 - $45
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Jacksonville to Orlando
Ave. Duration
2h 30m
Frequency
Twice daily
Estimated price
$15 - $26
Book at
megabus.com
Bus from Orlando to Gainesville
Ave. Duration
2h
Frequency
Once daily
Estimated price
$13 - $23
Book at
megabus.com
Red Coach
Phone
+1 877 733 0724
Email
webtickets@redcoachusa.com
Website
redcoachusa.com
Bus from Tampa Downtown to Gainesville - UF
Ave. Duration
3h 15m
Frequency
Once daily
Estimated price
$35 - $55
Book at
redcoachusa.com
First Class
$45 - $65
Business
$35 - $55
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Valdosta, GA to Gainesville, FL
Ave. Duration
1h 27m
Frequency
3 times a week
Estimated price
$159
Schedules at
lacubanabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Charleston to Gainesville is 309 miles. It takes approximately 5h 30m to drive from Charleston to Gainesville.

Get driving directions

American Airlines and Delta offer flights from Charleston Airport to Gainesville Airport.

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There are 52+ hotels available in Gainesville. Prices start at $59 USD per night.

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The best way to get from Charleston to Charleston Airport is to Shuttle Bus which takes 30m and costs $25.

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