There are 3 ways to get from Cayo Guillermo to Santa Clara by car, bus, taxi or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Drive, bus  •  6 h

  1. Drive from Cayo Guillermo to Cayo Santa María
  2. Take the bus from Cayo Santa María to Santa Clara Viazul

$7 - $17

2 alternative options

Taxi, train  •  4 h 27 min

  1. Take a taxi from Cayo Guillermo to Moron
  2. Take the train from Moron to Santa Clara

$74 - $90

Drive  •  3 h 55 min

  1. Drive from Cayo Guillermo to Santa Clara 161.6 miles

Questions & Answers

The cheapest way to get from Cayo Guillermo to Santa Clara is to drive and bus which costs $7 - $17 and takes 6 h.

More details

The quickest way to get from Cayo Guillermo to Santa Clara is to taxi and train which costs $70 - $90 and takes 4 h 27 min.

More details

The distance between Cayo Guillermo and Santa Clara is 137 km. The road distance is 258.5 km.

Get driving directions

It takes approximately 6 h to get from Cayo Guillermo to Santa Clara, including transfers.

More details

Map of how to get from Cayo Guillermo to Santa Clara.
Launch map view
  • Distance: 85.5 miles
  • Duration: 6 h

What companies run services between Cayo Guillermo, Cuba and Santa Clara, Cuba?

There is no direct connection from Cayo Guillermo to Santa Clara. However, you can take the drive to Cayo Santa María then take the bus to Santa Clara. Alternatively, you can take the taxi to Moron then take the train to Santa Clara.

Train operators
Ferrocarriles de Cuba
Website
en.wikipedia.org
Train from Moron to Santa Clara
Ave. Duration
3 h 4 min
Frequency
On demand
Estimated price
$8 - $12
Schedules at
seat61.com
Bus operators
Viazul
Other operators
Taxi from Cayo Guillermo to Moron
Ave. Duration
1 h 23 min
Estimated price
$65 - $80

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