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How to get fromCary to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Find Transport to St. Louis

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There are 7 ways to get from Cary to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    4h 54m
    $558–1,108

  2. Drive to Albert J. Ellis Airport, fly

    cheapest
    1. Drive from Cary to Albert J. Ellis Airport (OAJ)car car
    2. Fly from Albert J. Ellis Airport (OAJ) to Lambert–St. Louis International Airport (STL)plane plane OAJ - STL
    7h 9m
    $123–582

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    22h 29m
    $140–256

  4. Train (Amtrak)

    1. Take the train from Cary to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    30h 58m
    $743–1,149

  5. Drive  772.8 mi

    1. Drive from Cary to St. Louiscar car 772.8 mi
    14h 5m
    $141–204

  6. Train to Piedmont Triad International Airport, fly

    1. Take the train from Cary to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    7h 19m
    $183–754

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Cary to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 40m
    $189–698

Cary to St. Louis by bus

Calendar12Weekly Buses
Duration22h 29mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cary to St. Louis.ExpandLaunch map view
  • Distance: 693.4 mi
  • Duration: 4h 54m

What companies run services between Cary, NC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Cary Depot to St Louis Bus Station via Regional Transit Center, Durham Station, Durham, and Atlanta Bus Station in around 22h 29m.

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