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How to get fromCary to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train or bus (Greyhound)

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There are 6 ways to get from Cary to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    5h 6m
    $253–466

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to St Louis Bus Stationbus bus
    24h 14m
    $103–225

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    20h 54m
    $105–300

  4. Train (Amtrak)

    1. Take the train from Cary to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    31h 7m
    $203–650

  5. Drive 772.8 mi

    1. Drive from Cary to St. Louiscar car 772.8 mi
    14h 6m
    $141–204

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Cary to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 56m
    $247–431

Cary to St. Louis by bus

Calendar7Weekly Buses
Duration20h 54mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

What companies run services between Cary, NC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Cary Depot to St Louis Bus Station via Regional Transit Center, Durham Station Gate J, Durham, and Atlanta Bus Station in around 20h 54m.

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