There are 10 ways to get from Cary to Lexington by plane, car, bus (Flixbus, Greyhound), train, bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Raleigh-Durham International Airport to Louisville International Airport, drive
best- Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)RDU - SDF
- Drive from Louisville-Airport-SDF to Lexington
5h 4m$154–424Drive 442.1 mi
cheapest- Drive from Cary to Lexington442.1 mi
8h 51m$81–117Bus
- Take the bus from Durham to Atlanta DowntownFlixBus N2470
- Take the bus from Atlanta Bus Station to Lexington Bus StopGreyhound US0110
17h 4m$137–289Train, bus
- Take the train from Cary to Greensboro
- Take the train from Greensboro to Charlottesville
- Take the train from Charlottesville to Indianapolis
- Take the bus from Indianapolis Union Station to Lexington Bus Stop
27h 11m$184–436Fly Raleigh-Durham International Airport to Blue Grass Airport
- Fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX)RDU - LEX
8h 14m$122–805Train to Charlotte Douglas International Airport, fly to Louisville International Airport, drive
- Take the train from Cary to Charlotte Amtrak Station
- Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)CLT - SDF
- Drive from Louisville-Airport-SDF to Lexington
7h 49m$178–509Train to Charlotte Douglas International Airport, fly to Blue Grass Airport
- Take the train from Cary to Charlotte Amtrak Station
- Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)CLT - LEX
8h 43m$131–690Bus via Regional Transit Center
- Take the bus from Durham to Atlanta Bus StationFlixBus N2471 / ...
- Take the bus from Atlanta Bus Station to Lexington Bus StopGreyhound US0110
18h 36m$127–292Bus via Athens
- Take the bus from Raleigh to Marathon Gas - Oconee Loop - Athens
- Take the bus from Marathon Gas - Oconee Loop - Athens to Atlanta
- Take the bus from Atlanta Bus Station to Lexington Bus Stop
22h 44m$188–385Train, bus via Toledo
- Take the train from Cary to ToledoFloridian
- Take the bus from Toledo Bus Stop to Lexington Bus StopGreyhound US0110
29h 1m$150–373
Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Cary to Lexington is to drive which costs $80 - $120 and takes 8h 51m.
The fastest way to get from Cary to Lexington is to fly and drive which takes 5h 4m and costs $150 - $430.
The distance between Cary and Lexington is 512 miles. The road distance is 444.7 miles.
The best way to get from Cary to Lexington without a car is to bus which takes 17h 4m and costs $130 - $290.
It takes approximately 5h 4m to get from Cary to Lexington, including transfers.
The best way to get from Cary to Lexington is to bus which takes 17h 4m and costs $130 - $290. Alternatively, you can fly, which costs $120 - $850 and takes 8h 14m.
Yes, the driving distance between Cary to Lexington is 445 miles. It takes approximately 8h 51m to drive from Cary to Lexington.
There are 137+ hotels available in Lexington.
What companies run services between Cary, NC, USA and Lexington, KY, USA?
You can take a train from Cary to Lexington via Durham Amtrak Station, Durham, Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Lexington Bus Stop in around 17h 4m. Alternatively, American Airlines, Delta, and United Airlines fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX) hourly.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- aa.com
Flights from Raleigh-Durham International Airport to Louisville International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 41m
- When
- Every day
- Estimated price
- $85–500
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $120–800
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 5h 24m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $200–1,100
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Philadelphia
- Ave. Duration
- 6h 13m
- When
- Wednesday and Friday
- Estimated price
- $190–1,000
Flights from Charlotte Douglas International Airport to Louisville International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $60–410
Flights from Charlotte Douglas International Airport to Blue Grass Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $95–650
- Website
- delta.com
Flights from Raleigh-Durham International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $100–550
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $160–900
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 4h 20m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $180–950
Flights from Raleigh-Durham International Airport to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Reagan Washington
- Ave. Duration
- 7h 31m
- When
- Every day
- Estimated price
- $160–900
Flights from Charlotte Douglas International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- $80–460
Flights from Charlotte Douglas International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- $120–750
- Website
- southwest.com
Flights from Raleigh-Durham International Airport to Louisville International Airport via Baltimore
- Ave. Duration
- 3h 54m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $110–600
- Website
- united.com
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 34m
- When
- Every day
- Estimated price
- $200–1,100
- Website
- flybreeze.com
Flights from Raleigh-Durham International Airport to Louisville International Airport
- Ave. Duration
- 1h 32m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $200–310
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Cary to Greensboro
- Ave. Duration
- 1h 21m
- Frequency
- 5 times a day
- Estimated price
- $12–14
- Website
- https://www.amtrak.com/home.html
Train from Greensboro to Charlottesville
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $60–110
- Website
- https://www.amtrak.com/home.html
Train from Charlottesville to Indianapolis
- Ave. Duration
- 15h 23m
- Frequency
- 3 times a week
- Estimated price
- $55–200
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $55–150
- Coach Seat short notice purchase
- $75–200
- Business - advance purchase
- $100–440
- Business Class
- $170–450
Train from Cary to Charlotte Amtrak Station
- Ave. Duration
- 2h 58m
- Frequency
- 5 times a day
- Estimated price
- $28–33
- Website
- https://www.amtrak.com/home.html
Train from Cary to Toledo
- Ave. Duration
- 20h 44m
- Frequency
- Once daily
- Estimated price
- $75–260
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $75–210
- Coach Seat short notice purchase
- $100–260
- Business - advance purchase
- $140–600
- Business Class
- $230–600
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Durham to Atlanta Downtown
- Ave. Duration
- 6h 45m
- Frequency
- 6 times a week
- Estimated price
- $50–95
- Schedules at
- flixbus.com
Bus from Durham to Atlanta Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- 5 times a day
- Estimated price
- $50–110
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Estimated price
- $50–150
- Website
- https://www.greyhound.com/
Bus from Indianapolis Union Station to Lexington Bus Stop
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://www.greyhound.com/
Bus from Durham to Atlanta Bus Station
- Ave. Duration
- 8h 25m
- Frequency
- 4 times a day
- Estimated price
- $50–95
- Website
- https://www.greyhound.com/
Bus from Toledo Bus Stop to Lexington Bus Stop
- Ave. Duration
- 7h 5m
- Frequency
- Once daily
- Estimated price
- $45–90
- Website
- https://www.greyhound.com/
- Phone
- +1 404-591-2750
- info@southeasternstages.com
- Website
- southeasternstages.com
Bus from Raleigh to Marathon Gas - Oconee Loop - Athens
- Ave. Duration
- 8h 40m
- Frequency
- Once daily
- Estimated price
- $95–120
- Schedules at
- southeasternstages.com
Bus from Marathon Gas - Oconee Loop - Athens to Atlanta
- Ave. Duration
- 1h 20m
- Frequency
- Twice daily
- Estimated price
- $27–95
- Schedules at
- southeasternstages.com
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