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How to get fromCape Cod to St. Louisby bus, plane, bus (Greyhound, Flixbus), train, car or bus (Greyhound)

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There are 6 ways to get from Cape Cod to St. Louis by bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    7h 53m
    $314–546

  2. Drive 1,190.1 mi

    cheapest
    1. Drive from Cape Cod to St. Louiscar car 1,190.1 mi
    21h 27m
    $218–314

  3. Bus via Boston

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    31h 49m
    $230–443

  4. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 57m
    $375–808

  5. Fly from Barnstable Municipal Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Lambert–St. Louis International Airport (STL)plane plane HYA - STL
    8h 13m
    $279–1,409

  6. Bus

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    32h 4m
    $233–468

Cape Cod to St. Louis by bus

Calendar7Weekly Buses
Duration31h 49mAverage Duration
Ticket$230Cheapest Price
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Questions & Answers

What companies run services between Cape Cod, MA, USA and St. Louis, MO, USA?

You can take a bus from Town Hall Lawton Bus Shelter to St Louis Bus Station via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, and Newark Penn Station in around 31h 49m. Alternatively, American Airlines, Cape Air, and Delta fly from Barnstable Municipal Airport (HYA) to Lambert–St. Louis International Airport (STL) 3 times a day.

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