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There are 5 ways to get from Cali to Guayaquil by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 21 min

  1. Fly from Cali (CLO) to Guayaquil (GYE) CLO - GYE

$200 - $471

Cheapest option

Bus Expreso Internacional Ormeño  •  21 h 13 min

  1. Take the bus from Cali to Guayaquil Bogotá / ...

$69 - $93

3 alternative options

Bus Tiseca  •  23 h 13 min

  1. Take the bus from Cali to Guayaquil Via Cucuta / ...

$70 - $157

Bus Cruz del Sur  •  30 h 40 min

  1. Take the bus from Cali to Quito Terminal Quitumbe Via Lima
  2. Take the bus from Quito Terminal Quitumbe to Guayaquil

$122 - $160

Drive  •  19 h 50 min

  1. Drive from Cali to Guayaquil 754.9 miles

$75 - $120

Questions & Answers

The cheapest way to get from Cali to Guayaquil is to bus which costs $65 - $95 and takes 21 h 13 min.

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The quickest way to get from Cali to Guayaquil is to fly which costs $200 - $480 and takes 4 h 21 min.

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No, there is no direct bus from Cali to Guayaquil. However, there are services departing from Cali and arriving at Guayaquil via Quito Terminal Quitumbe. The journey, including transfers, takes approximately 30 h 40 min.

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The distance between Cali and Guayaquil is 732 km. The road distance is 1207.8 km.

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The best way to get from Cali to Guayaquil without a car is to bus which takes 21 h 13 min and costs $65 - $95.

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It takes approximately 4 h 21 min to get from Cali to Guayaquil, including transfers.

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Cali to Guayaquil bus services, operated by Cruz del Sur, depart from Cali station.

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The best way to get from Cali to Guayaquil is to fly which takes 4 h 21 min and costs $200 - $480. Alternatively, you can bus, which costs $65 - $95 and takes 21 h 13 min.

Mode details

The quickest flight from Cali Airport to Guayaquil Airport is the direct flight which takes 1 h 30 min.

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Cali to Guayaquil bus services, operated by Cooperativa de Transportes Aerotaxi, arrive at Guayaquil station.

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Map of how to get from Cali to Guayaquil.
Launch map view
  • Distance: 457.3 miles
  • Duration: 4 h 21 min

What companies run services between Cali, Colombia and Guayaquil, Ecuador?

Avianca - Aerovías del Continente Americano S.A. flies from Cali to Guayaquil twice daily. Alternatively, Expreso Internacional Ormeño operates a bus from Cali to Guayaquil 4 times a week. Tickets cost $45 - $70 and the journey takes 21 h.

Airlines
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Cali to Guayaquil
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$370 - $900
Flights from Cali to Guayaquil via Bogota
Ave. Duration
4 h
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$370 - $900
Bus operators
Tiseca
Phone
+58 276 7713091
Website
tiseca.com.ve
Bus from Cali to Guayaquil
Ave. Duration
23 h
Frequency
Hourly
Estimated price
$133
Schedules at
tiseca.com.ve
Conexiones Siglo 21
Phone
+57 311 357 5623
Email
ayuda@conexionesiglo21.com
Website
conexionesiglo21.com
Bus from Cali to Guayaquil
Ave. Duration
23 h
Frequency
Every 4 hours
Estimated price
$129
Schedules at
conexionesiglo21.com
Alianza Internacional del Sur
Website
facebook.com
Bus from Cali to Guayaquil
Ave. Duration
22 h
Frequency
6 times a week
Schedules at
venezuelatravelinternational.com
Book at
venezuelatravelinternational.com
Cruz del Sur
Phone
+51 1 311-5050
Website
cruzdelsur.com.pe
Bus from Cali to Quito Terminal Quitumbe
Ave. Duration
20 h 30 min
Frequency
Once a week
Estimated price
$100 - $150
Schedules at
cruzdelsur.com.pe
Book at
cruzdelsur.com.pe
Cooperativa de Transportes Aerotaxi
Phone
593 99 195 2081
Email
transportesaerotaxi@yahoo.com
Website
coop_transporte_aerotaxi.amawebs.com
Bus from Quito Terminal Quitumbe to Guayaquil
Ave. Duration
9 h 10 min
Frequency
Every 4 hours
Estimated price
$14
Schedules at
coop_transporte_aerotaxi.amawebs.com
Book at
andestransit.com

Want to know more about travelling around the world?

Rome2rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Why you should take the train in the US, Travel Insider: Top Japan travel tips by Beatrix Holland and Train travel in Spain: A guide to Renfe - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Cali to Guayaquil is 1208 km. It takes approximately 19 h 50 min to drive from Cali to Guayaquil.

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Avianca - Aerovías del Continente Americano S.A. offers flights from Cali Airport to Guayaquil Airport.

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There are 306+ hotels available in Guayaquil. Prices start at $25 USD per night.

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The best way to get from Cali to Cali Airport is to bus which takes 40 min and costs $1 - $8.

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