There are 4 ways to get from Cali to Guayaquil by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 21 min

  1. Fly from Cali (CLO) to Guayaquil (GYE) CLO - GYE

$200 - $471

Cheapest option

Bus Expreso Internacional Ormeño  •  21 h 13 min

  1. Take the bus from Cali to Guayaquil Via Lima / ...

$73 - $96

2 alternative options

Bus Cruz del Sur  •  30 h 40 min

  1. Take the bus from Cali to Quito Terminal Quitumbe Via Lima
  2. Take the bus from Quito Terminal Quitumbe to Guayaquil

$123 - $161

Drive  •  19 h 50 min

  1. Drive from Cali to Guayaquil 754.9 miles

$75 - $120

Questions & Answers

The cheapest way to get from Cali to Guayaquil is to bus which costs $70 - $100 and takes 21 h 13 min.

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The quickest way to get from Cali to Guayaquil is to fly which costs $200 - $480 and takes 4 h 21 min.

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No, there is no direct bus from Cali to Guayaquil. However, there are services departing from Cali and arriving at Guayaquil via Quito Terminal Quitumbe. The journey, including transfers, takes approximately 30 h 40 min.

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The distance between Cali and Guayaquil is 732 km. The road distance is 1207.8 km.

Get driving directions

The best way to get from Cali to Guayaquil without a car is to bus which takes 21 h 13 min and costs $70 - $100.

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It takes approximately 4 h 21 min to get from Cali to Guayaquil, including transfers.

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Cali to Guayaquil bus services, operated by Cruz del Sur, depart from Cali station.

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The best way to get from Cali to Guayaquil is to fly which takes 4 h 21 min and costs $200 - $480. Alternatively, you can bus, which costs $70 - $100 and takes 21 h 13 min.

Mode details

Map of how to get from Cali to Guayaquil.
Launch map view
  • Distance: 457.3 miles
  • Duration: 4 h 21 min

What companies run services between Cali, Colombia and Guayaquil, Ecuador?

Avianca - Aerovías del Continente Americano S.A. flies from Cali to Guayaquil 3 times a day. Alternatively, Expreso Internacional Ormeño operates a bus from Cali to Guayaquil 4 times a week. Tickets cost $50 - $75 and the journey takes 21 h.

Airlines
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Cali to Guayaquil
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$370 - $900
Flights from Cali to Guayaquil via Bogota
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$370 - $900
Bus operators

Want to know more about travelling around the world?

Rome2rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to get from Luton Airport into central London, Heading to Europe? Read this before you buy a Eurail Pass and Train travel in Spain: A guide to Renfe - to help you get the most out of your next trip.

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