JetSMART, LATAM Chile and Sky Airline fly from Calama to Santiago hourly. Alternatively, Expreso Norte operates a bus from Calama to Santiago twice daily. Tickets cost $21 - $60 and the journey takes 19 h 35 min. Expreso Norte also services this route hourly.
From Calama shuttle to Calama airport, fly to Santiago airport, then shuttle to Santiago. 3 h 56 min $178. From Calama bus to La Calera then bus to Santiago - San Borja. 21 h 18 min $69. From Calama bus to Santiago - San Borja. 22 h $53. From Calama drive to Santiago. 17 h 31 min $198.