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How to get fromBuffalo to Wiseby plane, car, bus or train

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There are 6 ways to get from Buffalo to Wise by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport, drive

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane BUF - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    7h 15m
    $175–993

  2. Drive 565.7 mi

    cheapest
    1. Drive from Buffalo to Wisecar car 565.7 mi
    11h 8m
    $104–150

  3. Bus, drive

    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Wythevillebus bus
    4. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    16h 44m
    $106–239

  4. Bus to Rochester, fly, drive

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ROC - TRI
    3. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    8h 38m
    $166–860

  5. Bus, drive via New York

    1. Take the bus from Buffalo to New York Midtownbus bus
    2. Take the bus from New York, NY to Johnson City, TNbus bus Ny
    3. Drive from Johnson City, TN to Wisecar car
    22h 2m
    $157–219

  6. Bus, train, drive

    1. Take the bus from Buffalo to Pittsburghbus bus
    2. Take the train from Pittsburgh Amtrak Station to Washington Union Stationtrain train
    3. Take the bus from Washington Union Station to Bristol Exit 5 Park & Ride Lotbus bus
    4. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    26h 41m
    $169–405

Buffalo Niagara International Airport (BUF) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar38Weekly Planes
Duration5h 53mAverage Duration
Ticket$165Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Wise, VA, USA?

There is no direct connection from Buffalo to Wise. However, you can take the bus to Buffalo Niagara International Airport, walk to Buffalo Niagara International Airport (BUF) airport, fly to Tri-Cities Regional Tn/Va Airport (TRI), then drive to Wise. Alternatively, you can take a bus from Buffalo, NY to Wise via Robert K Pfaff Transit Center - Akron, Charleston, WV, Wytheville, Wytheville Rural King Parking Lot, and Bristol Exit 5 Park & Ride Lot in around 16h 44m.

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