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How to get fromBuffalo to Santa Anaby plane, train (Amtrak), bus (Greyhound), car, or train

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There are 6 ways to get from Buffalo to Santa Ana by plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA)plane plane BUF - SNA
    8h 15m
    $251–937

  2. Fly to Long Beach Airport

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Long Beach Airport (LGB)plane plane BUF - LGB
    11h 15m
    $147–659

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2d 8h
    $688–1,752

  4. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to El Monte Bus Stopbus bus
    4. Take the bus from El Monte to Santa Anabus bus
    2d 12h
    $415–701

  5. Drive  2,526.4 mi

    1. Drive from Buffalo to Santa Anacar car 2,526.4 mi
    40h 17m
    $462–666

  6. Fly to Los Angeles International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Los Angeles International Airport (LAX)plane plane BUF - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    11h 8m
    $238–446

Buffalo to Santa Ana by train (Amtrak)

Calendar7Weekly Trains
Duration2d 8hAverage Duration
Ticket$688Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Santa Ana.ExpandLaunch map view
  • Distance: 2,212 mi
  • Duration: 8h 15m

What companies run services between Buffalo, NY, USA and Santa Ana, CA, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, you can take a train from Buffalo to Santa Ana via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 8h.

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