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How to get fromBuffalo to Santa Anaby plane, train (Amtrak), bus (Greyhound, Amtrak), car or train

Find Transport to Santa Ana

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There are 6 ways to get from Buffalo to Santa Ana by plane, train (Amtrak), bus (Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA)plane plane BUF - SNA
    8h 44m
    $363–1,515

  2. Fly to Los Angeles International Airport, train

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Los Angeles International Airport (LAX)plane plane BUF - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain train
    9h 43m
    $232–1,004

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2d 8h
    $278–1,782

  4. Bus

    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus
    2. Take the bus from Columbus to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to Santa Anabus bus
    2d 11h

  5. Drive 2,527.1 mi

    1. Drive from Buffalo to Santa Anacar car 2,527.1 mi
    40h 14m
    $462–667

  6. Fly to Long Beach Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Long Beach Airport (LGB)plane plane BUF - LGB
    11h 45m
    $284–1,293

Buffalo to Santa Ana by train (Amtrak)

Calendar13Weekly Trains
Duration2d 8hAverage Duration
Ticket$278Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Santa Ana, CA, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA) every 4 hours. Alternatively, you can take a train from Buffalo to Santa Ana via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 8h.

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