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How to get fromBuffalo to Santa Anaby plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Find Transport to Santa Ana

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There are 6 ways to get from Buffalo to Santa Ana by plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA)plane plane BUF - SNA
    8h 31m
    $235–913

  2. Fly to Los Angeles International Airport, train

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Los Angeles International Airport (LAX)plane plane BUF - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    9h 38m
    $142–551

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2d 8h
    $1,488–2,492

  4. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles Union Station to Anaheim Regional Transportation Intermodal Centerbus bus
    2d 13h
    $466–760

  5. Drive  2,526.4 mi

    1. Drive from Buffalo to Santa Anacar car 2,526.4 mi
    40h 17m
    $432–624

  6. Fly to Long Beach Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Long Beach Airport (LGB)plane plane BUF - LGB
    11h 50m
    $181–735

Buffalo to Santa Ana by train (Amtrak)

Calendar7Weekly Trains
Duration2d 8hAverage Duration
Ticket$1,488Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Santa Ana.ExpandLaunch map view
  • Distance: 2,210.2 mi
  • Duration: 8h 31m

What companies run services between Buffalo, NY, USA and Santa Ana, CA, USA?

Delta, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to John Wayne Airport Orange County (SNA) every 3 hours. Alternatively, you can take a train from Buffalo to Santa Ana via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 8h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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