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How to get fromBuffalo to San Diegoby plane, train (Amtrak), bus (Greyhound, Amtrak), car, bus or shuttle

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There are 6 ways to get from Buffalo to San Diego by plane, train (Amtrak), bus (Greyhound, Amtrak), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to San Diego International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN)planeBUF - SAN
    8h 52m
    $284–1,207

  2. Fly Buffalo Niagara International Airport to Los Angeles International Airport, bus

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Los Angeles International Airport (LAX)planeBUF - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus
    10h 46m
    $237–912

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
    3. Take the train from Fullerton Amtrak Station to San Diegotrain
    2d 10h
    $280–647

  4. Bus

    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus
    2. Take the bus from Columbus to St Louis Bus Stationbus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
    4. Take the bus from Los Angeles to San Diegobus
    2d 14h

  5. Drive 2,534.4 mi

    1. Drive from Buffalo to San Diegocar2,534.4 mi
    41h 23m
    $463–669

  6. Shuttle to Toronto Pearson International Airport, fly to San Diego International Airport

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle
    2. Fly from Toronto Pearson International Airport (YYZ) to San Diego International Airport (SAN)planeYYZ - SAN
    11h 10m
    $334–1,317

Buffalo to San Diego by train (Amtrak)

Calendar13Weekly Trains
Duration2d 10hAverage Duration
Ticket$280Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and San Diego, CA, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN) every 3 hours. Alternatively, you can take a train from Buffalo to San Diego via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 10h.

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