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How to get fromBuffalo to Myrtle Beachby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 6 ways to get from Buffalo to Myrtle Beach by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR)plane plane BUF - MYR
    4h 56m
    $107–522

  2. Bus

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Wilmington Cape Fear Public Transitbus bus
    4. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    24h 45m
    $164–321

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    26h 50m
    $389–780

  4. Drive 760.8 mi

    1. Drive from Buffalo to Myrtle Beachcar car 760.8 mi
    15h 35m
    $139–201

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Myrtle Beach (MYR)plane plane ROC - MYR
    4h 43m
    $220–758

  6. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    34h 29m
    $308–735

Buffalo to Myrtle Beach by bus

Calendar7Weekly Buses
Duration24h 45mAverage Duration
Ticket$164Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Myrtle Beach.ExpandLaunch map view
  • Distance: 652.7 mi
  • Duration: 4h 56m

What companies run services between Buffalo, NY, USA and Myrtle Beach, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR) hourly. Alternatively, you can take a bus from Buffalo to Myrtle Beach Bus Station via Newark Penn Station, Raleigh Bus Station, and Wilmington Cape Fear Public Transit in around 24h 45m.

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