There are 6 ways to get from Buffalo to Lowell by plane, train, bus, train (Amtrak), car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Buffalo Niagara International Airport, train
best- Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane BUF - BOS
- Take the train from Anderson/Woburn to Lowelltrain
4h 38m$116–747Bus, train
cheapest- Take the bus from Buffalo, NY to Syracuse, NYbus
- Take the bus from Syracuse, NY to Boston, MAbus
- Take the train from North Station to Lowelltrain
12h 28m$55–137Train
- Take the train from Buffalo Depew Station to Bostontrain Lake Shore Limited
- Take the train from North Station to Lowelltrain Lowell Line
14h 17m$126–538Drive 435.7 mi
- Drive from Buffalo to Lowellcar 435.7 mi
8h 43m$80–115Bus to Rochester, fly
- Take the bus from Buffalo, NY to Rochester, NYbus
- Fly from Rochester (ROC) to Boston Logan Airport (BOS)plane ROC - BOS
6h 57m$206–642Bus
- Take the bus from Buffalo to Syracuse Bus Stationbus
- Take the bus from Syracuse Bus Station to Bostonbus
- Take the bus from Boston to Robert B Kennedy Bus Transfer Centerbus
13h 15m$83–185
Buffalo to Lowell by bus, tram, and train
Questions & Answers
The cheapest way to get from Buffalo to Lowell is to bus and train which costs $55 - $140 and takes 12h 28m.
The fastest way to get from Buffalo to Lowell is to fly and train which takes 4h 38m and costs $110 - $750.
No, there is no direct bus from Buffalo to Lowell. However, there are services departing from Buffalo and arriving at Robert B Kennedy Bus Transfer Center via Syracuse Bus Station and Boston. The journey, including transfers, takes approximately 13h 15m.
No, there is no direct train from Buffalo to Lowell. However, there are services departing from Buffalo and arriving at Lowell via Buffalo Depew Station, Back Bay and North Station. The journey, including transfers, takes approximately 14h 17m.
The distance between Buffalo and Lowell is 435 miles. The road distance is 438.2 miles.
The best way to get from Buffalo to Lowell without a car is to bus and train which takes 12h 28m and costs $55 - $140.
It takes approximately 4h 38m to get from Buffalo to Lowell, including transfers.
Buffalo to Lowell bus services, operated by Flixbus USA, depart from Buffalo station.
Buffalo to Lowell train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Lowell is to train which takes 14h 17m and costs $120 - $550. Alternatively, you can bus, which costs $80 - $190 and takes 13h 15m.
What companies run services between Buffalo, NY, USA and Lowell, MA, USA?
You can take a train from Buffalo to Lowell via Buffalo Depew Station, Boston, Back Bay, North Station, and North Station in around 14h 17m. Alternatively, you can take a bus from Buffalo to Robert B Kennedy Bus Transfer Center via Syracuse Bus Station and Boston in around 13h 15m.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 32m
- When
- Sunday
- Estimated price
- $100–650
Flights from Rochester to Boston Logan Airport
- Ave. Duration
- 1h 39m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–500
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport via New York La Guardia
- Ave. Duration
- 3h 40m
- When
- Monday to Friday
- Estimated price
- $110–700
Flights from Rochester to Boston Logan Airport via New York La Guardia
- Ave. Duration
- 3h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–550
Flights from Rochester to Boston Logan Airport via New York JFK
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $85–550
- Website
- united.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport via Newark
- Ave. Duration
- 3h 45m
- When
- Monday to Saturday
- Estimated price
- $110–700
Flights from Rochester to Boston Logan Airport via Newark
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $85–550
- Website
- jetblue.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $100–650
- Website
- southwest.com
Flights from Rochester to Boston Logan Airport via Baltimore
- Ave. Duration
- 4h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Anderson/Woburn to Lowell
- Ave. Duration
- 24 min
- Frequency
- Hourly
- Estimated price
- $3–8
- Website
- https://www.mbta.com
- Adult
- $3–8
Train from North Station to Lowell
- Ave. Duration
- 47 min
- Frequency
- Hourly
- Estimated price
- $4–11
- Website
- https://www.mbta.com
- Adult
- $4–11
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Boston
- Ave. Duration
- 11h 19m
- Frequency
- Once daily
- Estimated price
- $110–450
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Buffalo, NY to Syracuse, NY
- Ave. Duration
- 2h 50m
- Frequency
- 4 times a week
- Estimated price
- $26–31
- Website
- https://www.ourbus.com
Bus from Syracuse, NY to Boston, MA
- Ave. Duration
- 5h 10m
- Frequency
- Once a week
- Estimated price
- $20–90
- Website
- https://www.ourbus.com
Bus from Buffalo, NY to Rochester, NY
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Syracuse Bus Station
- Ave. Duration
- 2h 50m
- Frequency
- Every 4 hours
- Estimated price
- $27–40
- Schedules at
- flixbus.com
Bus from Syracuse Bus Station to Boston
- Ave. Duration
- 6h 20m
- Frequency
- 5 times a week
- Estimated price
- $45–130
- Schedules at
- flixbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Buffalo to Syracuse Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $27–40
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Syracuse Bus Station
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a day
- Estimated price
- $27–45
- Website
- https://www.greyhound.com/
Bus from Syracuse Bus Station to Boston
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Estimated price
- $45–120
- Website
- https://www.greyhound.com/
Bus from Boston to Robert B Kennedy Bus Transfer Center
- Ave. Duration
- 45 min
- Frequency
- 5 times a week
- Estimated price
- $10–14
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Buffalo to Lowell bus services, operated by Flixbus USA, arrive at Syracuse Bus Station.
Buffalo to Lowell train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between Buffalo to Lowell is 438 miles. It takes approximately 8h 43m to drive from Buffalo to Lowell.
Book your Buffalo to Lowell bus tickets online with Omio and FlixBus.
There are 80+ hotels available in Lowell.

















