There are 5 ways to get from Buffalo to Lexington by plane, car, bus (Greyhound), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Louisville International Airport, drive
best- Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)BUF - SDF
- Drive from Louisville-Airport-SDF to Lexington
6h 34m$158–951Bus
cheapest- Take the bus from Buffalo, NY to Cincinnati, OHBuffalo
- Take the bus from Cincinnati Bus Station to Lexington Bus StopGreyhound US0110 / ...
12h 52m$91–177Drive 519 mi
- Drive from Buffalo to Lexington519 mi
8h 48m$95–137Fly Buffalo Niagara International Airport to Blue Grass Airport
- Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)BUF - LEX
7h 28m$236–1,482Bus to Rochester, fly to Blue Grass Airport
- Take the bus from Buffalo, NY to Rochester, NY
- Fly from Rochester (ROC) to Blue Grass Airport (LEX)ROC - LEX
9h 38m$216–1,237
Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Buffalo to Lexington is to drive which costs $90 - $140 and takes 8h 48m.
The fastest way to get from Buffalo to Lexington is to fly and drive which takes 6h 34m and costs $150 - $950.
The distance between Buffalo and Lexington is 586 miles. The road distance is 522 miles.
The best way to get from Buffalo to Lexington without a car is to bus which takes 12h 52m and costs $90 - $180.
It takes approximately 6h 34m to get from Buffalo to Lexington, including transfers.
The best way to get from Buffalo to Lexington is to bus which takes 12h 52m and costs $90 - $180. Alternatively, you can fly, which costs $230 - $1,500 and takes 7h 28m.
Yes, the driving distance between Buffalo to Lexington is 522 miles. It takes approximately 8h 48m to drive from Buffalo to Lexington.
There are 120+ hotels available in Lexington.
What companies run services between Buffalo, NY, USA and Lexington, KY, USA?
You can take a bus from Buffalo, NY to Lexington via Cincinnati, OH, Cincinnati Bus Station, and Lexington Bus Stop in around 12h 52m. Alternatively, Delta, American Airlines, and United Airlines fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX) every 2 hours.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Louisville International Airport via Reagan Washington
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $170–950
Flights from Buffalo Niagara International Airport to Louisville International Airport via Charlotte
- Ave. Duration
- 5h 33m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $180–1,000
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $290–1,600
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $280–1,500
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Philadelphia
- Ave. Duration
- 6h 37m
- When
- Tuesday and Wednesday
- Estimated price
- $280–1,500
Flights from Rochester to Blue Grass Airport via Charlotte
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $240–1,300
Flights from Rochester to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 36m
- When
- Every day
- Estimated price
- $230–1,300
Flights from Rochester to Blue Grass Airport via Philadelphia
- Ave. Duration
- 5h 45m
- When
- Tuesday
- Estimated price
- $220–1,200
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 4h 40m
- When
- Monday, Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- $140–850
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 4h 8m
- When
- Monday, Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- $230–1,400
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $330–1,700
Flights from Buffalo Niagara International Airport to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 6h 20m
- When
- Saturday and Sunday
- Estimated price
- $300–1,600
Flights from Rochester to Blue Grass Airport via Detroit
- Ave. Duration
- 4h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $190–1,100
Flights from Rochester to Blue Grass Airport via Atlanta
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $270–1,400
Flights from Rochester to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 6h 11m
- When
- Saturday and Sunday
- Estimated price
- $240–1,300
- Website
- united.com
Flights from Buffalo Niagara International Airport to Louisville International Airport via Washington Dulles
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $170–900
Flights from Buffalo Niagara International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 5m
- When
- Every day
- Estimated price
- $280–1,500
Flights from Rochester to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $230–1,300
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 4h 12m
- When
- Monday, Wednesday, Thursday, and Friday
- Estimated price
- $170–950
Flights from Buffalo Niagara International Airport to Louisville International Airport via Baltimore
- Ave. Duration
- 4h 38m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–950
Flights from Buffalo Niagara International Airport to Louisville International Airport via Chicago Midway
- Ave. Duration
- 5h 2m
- When
- Monday, Thursday, and Friday
- Estimated price
- $170–900
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Buffalo, NY to Cincinnati, OH
- Ave. Duration
- 10h
- Frequency
- Once daily
- Estimated price
- $45–95
- Website
- https://baronsbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Cincinnati Bus Station to Lexington Bus Stop
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $19–50
- Website
- https://www.greyhound.com/
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Buffalo, NY to Rochester, NY
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
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