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There are 5 ways to get from Buffalo to Knoxville by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Buffalo  •  5 h 22 min

  1. Fly from Buffalo (BUF) to Knoxville (TYS) BUF - TYS

$237 - $972

Cheapest option

Bus  •  14 h 30 min

  1. Take the bus from Buffalo, NY to Cincinnati, OH Buffalo
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$68 - $162

3 alternative options

Train to Rochester, fly  •  7 h 14 min

  1. Take the train from Buffalo Amtrak Station to Rochester Amtrak Station
  2. Fly from Rochester (ROC) to Knoxville (TYS) ROC - TYS

$292 - $1,124

Train, bus  •  17 h 29 min

  1. Take the train from Buffalo Depew Station to Toledo Amtrak Station
  2. Take the bus from Toledo, Oh to Cincinnati, Oh
  3. Take the bus from Cincinnati, Oh to Knoxville, Tn

$123 - $301

Drive  •  11 h 28 min

  1. Drive from Buffalo to Knoxville 689.1 miles

$65 - $100

Questions & Answers

The cheapest way to get from Buffalo to Knoxville is to drive which costs $65 - $100 and takes 11 h 28 min.

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The quickest way to get from Buffalo to Knoxville is to fly which costs $230 - $1,000 and takes 5 h 22 min.

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No, there is no direct bus from Buffalo to Knoxville. However, there are services departing from Buffalo, NY and arriving at Knoxville, Tn via Cincinnati, Oh. The journey, including transfers, takes approximately 14 h 30 min.

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The distance between Buffalo and Knoxville is 552 miles. The road distance is 689.1 miles.

Get driving directions

The best way to get from Buffalo to Knoxville without a car is to bus which takes 14 h 30 min and costs $65 - $170.

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It takes approximately 5 h 22 min to get from Buffalo to Knoxville, including transfers.

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Buffalo to Knoxville bus services, operated by Barons Bus, depart from Buffalo, NY station.

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The best way to get from Buffalo to Knoxville is to fly which takes 5 h 22 min and costs $230 - $1,000. Alternatively, you can bus, which costs $65 - $170 and takes 14 h 30 min.

Mode details

There is no direct flight from Buffalo Airport to Knoxville Airport. The quickest flight takes 3 h 47 min and has one stopover.

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Buffalo to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Map of how to get from Buffalo to Knoxville.
Launch map view
  • Distance: 552 miles
  • Duration: 5 h 22 min

What companies run services between Buffalo, NY, USA and Knoxville, TN, USA?

United Airlines, American Airlines and Delta fly from Buffalo to Knoxville hourly. Alternatively, you can take a bus from Buffalo to Knoxville via Cincinnati, OH and Cincinnati, Oh in around 14 h 30 min.

Airlines
Delta
Website
delta.com
Flights from Buffalo to Knoxville via Atlanta
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via Detroit
Ave. Duration
4 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from Buffalo to Knoxville via New York La Guardia
Ave. Duration
5 h 19 min
When
Monday to Friday
Estimated price
$190 - $950
Flights from Rochester to Knoxville via Detroit
Ave. Duration
4 h 47 min
When
Every day
Estimated price
$190 - $950
Flights from Rochester to Knoxville via Atlanta
Ave. Duration
5 h 8 min
When
Every day
Estimated price
$200 - $1,000
Flights from Rochester to Knoxville via New York La Guardia
Ave. Duration
5 h 14 min
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$200 - $1,000
American Airlines
Website
aa.com
Flights from Buffalo to Knoxville via Reagan Washington
Ave. Duration
4 h 12 min
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via Charlotte
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$190 - $900
Flights from Buffalo to Knoxville via Philadelphia
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$200 - $950
Flights from Rochester to Knoxville via Charlotte
Ave. Duration
4 h 48 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Rochester to Knoxville via Reagan Washington
Ave. Duration
4 h 20 min
When
Monday to Friday
Estimated price
$200 - $1,000
Flights from Rochester to Knoxville via Chicago O'Hare
Ave. Duration
5 h 45 min
When
Every day
Estimated price
$230 - $1,000
Flights from Rochester to Knoxville via Philadelphia
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$210 - $1,000
United Airlines
Website
united.com
Flights from Buffalo to Knoxville via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Knoxville via Newark
Ave. Duration
5 h 24 min
When
Every day
Estimated price
$220 - $1,000
Flights from Buffalo to Knoxville via Chicago O'Hare
Ave. Duration
5 h 59 min
When
Every day
Estimated price
$220 - $1,000
Flights from Rochester to Knoxville via Washington Dulles
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Knoxville via Chicago O'Hare
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$240 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from Rochester to Knoxville via Orlando Sanford
Ave. Duration
6 h 30 min
When
Thursday and Sunday
Estimated price
$210 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Buffalo Amtrak Station to Rochester Amtrak Station
Ave. Duration
1 h 8 min
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Buffalo Depew Station to Toledo Amtrak Station
Ave. Duration
5 h 35 min
Frequency
Twice daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $330
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Rochester
Ave. Duration
1 h 8 min
Frequency
Once daily
Estimated price
$40 - $85
Website
viarail.ca
Escape
$19 - $40
Economy
$40 - $55
EconomyPlus
$55 - $85
Business
$55 - $80
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
4 h 25 min
Frequency
5 times a day
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Toledo, Oh to Cincinnati, Oh
Ave. Duration
4 h 15 min
Frequency
4 times a day
Estimated price
$25 - $60
Website
greyhound.com
Economy
$25 - $40
Flexible
$45 - $60

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Buffalo to Knoxville is 689 miles. It takes approximately 11 h 28 min to drive from Buffalo to Knoxville.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Buffalo Airport to Knoxville Airport.

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There are 106+ hotels available in Knoxville. Prices start at $54 USD per night.

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The best way to get from Buffalo to Buffalo Airport is to line 204 bus which takes 17 min and costs $2.

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