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How to get fromBuffalo to Key Westby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 6 ways to get from Buffalo to Key West by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane plane BUF - EYW
    6h 30m
    $88–375

  2. Bus

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    41h 11m
    $299–456

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    44h 51m
    $1,034–1,633

  4. Drive  1,536.5 mi

    1. Drive from Buffalo to Key Westcar car 1,536.5 mi
    26h 32m
    $254–367

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Key West International Airport (EYW)plane plane ROC - EYW
    7h 46m
    $151–606

  6. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 4h
    $944–1,676

Buffalo to Key West by bus and foot

Calendar4Weekly Services
Duration41h 11mAverage Duration
Ticket$299Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Key West.ExpandLaunch map view
  • Distance: 1,295.9 mi
  • Duration: 6h 30m

What companies run services between Buffalo, NY, USA and Key West, FL, USA?

Delta, American Airlines, and United Airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a bus from Buffalo to N Roosevelt & 3rd Street via Newark Penn Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 41h 11m.

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Want to know more about travelling around United States

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