There are 7 ways to get from Buffalo to Key West by plane, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Buffalo Niagara International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane BUF - EYW
6h 26m$247–1,241Fly from Niagara Falls International Airport
cheapest- Fly from Niagara Falls International Airport (IAG) to Key West International Airport (EYW)plane IAG - EYW
15h 33m$145–667Bus, train via Newark
- Take the bus from Buffalo to Newark Penn Stationbus
- Take the train from Newark Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
43h 51m$419–938Drive 1,536.5 mi
- Drive from Buffalo to Key Westcar 1,536.5 mi
26h 32m$281–405Bus to Rochester, fly
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Key West International Airport (EYW)plane ROC - EYW
7h 51m$218–958Train, bus
- Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
44h 56m$478–1,054Bus, train
- Take the bus from Buffalo to Pittsburghbus
- Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
2d 4h$466–1,093
Buffalo to Key West by bus, train, taxi, and foot
Questions & Answers
The cheapest way to get from Buffalo to Key West is to drive which costs $280 - $410 and takes 26h 32m.
The fastest way to get from Buffalo to Key West is to fly which takes 6h 26m and costs $240 - $1,300.
The distance between Buffalo and Key West is 1302 miles. The road distance is 1545.5 miles.
The best way to get from Buffalo to Key West without a car is to bus and train via Newark which takes 43h 51m and costs $410 - $950.
It takes approximately 6h 26m to get from Buffalo to Key West, including transfers.
Yes, the driving distance between Buffalo to Key West is 1545 miles. It takes approximately 26h 32m to drive from Buffalo to Key West.
There are 943+ hotels available in Key West.
What companies run services between Buffalo, NY, USA and Key West, FL, USA?
Delta, American Airlines, and four other airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) 5 times a day.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Reagan Washington
- Ave. Duration
- 6h 2m
- When
- Tuesday
- Estimated price
- $230–1,200
Flights from Buffalo Niagara International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 54m
- When
- Every day
- Estimated price
- $230–1,200
Flights from Rochester to Key West International Airport via Charlotte
- Ave. Duration
- 6h 55m
- When
- Every day
- Estimated price
- $180–900
Flights from Rochester to Key West International Airport via Miami
- Ave. Duration
- 8h 19m
- When
- Saturday
- Estimated price
- $180–900
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 6h 33m
- When
- Every day
- Estimated price
- $240–1,200
Flights from Rochester to Key West International Airport via Atlanta
- Ave. Duration
- 7h 16m
- When
- Every day
- Estimated price
- $190–900
- Website
- allegiantair.com
Flights from Niagara Falls International Airport to Key West International Airport via St. Petersburg
- Ave. Duration
- 12h 14m
- When
- Thursday and Sunday
- Estimated price
- $130–650
Flights from Niagara Falls International Airport to Key West International Airport via Punta Gorda, Asheville
- Ave. Duration
- 20h 38m
- When
- Saturday
- Estimated price
- $220–950
- Website
- flybreeze.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Tampa
- Ave. Duration
- 5h 6m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $230–1,200
- Website
- spirit.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Fort Lauderdale
- Ave. Duration
- 5h 10m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $230–1,200
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Newark Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 6m
- Frequency
- Once daily
- Estimated price
- $330–750
- Website
- https://www.amtrak.com/home.html
Train from Buffalo to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 8h 27m
- Frequency
- 3 times a day
- Estimated price
- $100–240
- Website
- https://www.amtrak.com/home.html
Train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 29m
- Frequency
- Once daily
- Estimated price
- $330–750
- Website
- https://www.amtrak.com/home.html
Train from Pittsburgh Amtrak Station to Miami Amtrak Station
- Ave. Duration
- 36h 49m
- Frequency
- Once daily
- Estimated price
- $380–850
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Newark Penn Station
- Ave. Duration
- 7h 45m
- Frequency
- 5 times a day
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 15m
- Frequency
- Every 3 hours
- Estimated price
- $8–15
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Newark Penn Station
- Ave. Duration
- 8h 15m
- Frequency
- Once daily
- Estimated price
- $65–120
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $21–40
- Website
- https://www.greyhound.com/
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 25m
- Frequency
- 3 times a day
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 814-574-1827
- Website
- fullingtontours.com
Bus from Buffalo to Pittsburgh
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $100–200
- Website
- https://www.fullingtontours.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Buffalo to Pittsburgh
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $40–180
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $40–170
- Flexible
- $80–180
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