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How to get fromBuffalo to Iowaby plane, bus (Greyhound), train, bus, or car

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There are 8 ways to get from Buffalo to Iowa by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Des Moines

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    5h 16m
    $233–1,149

  2. Fly to Quad City International Airport

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Quad City International Airport (MLI)plane plane BUF - MLI
    7h 39m
    $108–630

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    19h 15m
    $138–256

  4. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    19h 34m
    $230–580

  5. Drive 846.5 mi

    1. Drive from Buffalo to Des Moinescar car 846.5 mi
    14h 17m
    $155–224

  6. Fly to Omaha

    1. Fly from Buffalo Niagara International Airport (BUF) to Omaha (OMA)plane plane BUF - OMA
    5h 30m
    $241–1,158

  7. Train, bus via Galesburg

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    21h 26m
    $260–655

  8. Bus via Akron

    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland, OHbus bus
    3. Take the bus from Cleveland to Chicagobus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 50m
    $118–287

Buffalo Niagara International Airport (BUF) to Des Moines (DSM) flights

Calendar101Weekly Planes
Duration6h 5mAverage Duration
Ticket$217Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Iowa.ExpandLaunch map view
  • Distance: 785.3 mi
  • Duration: 5h 16m

What companies run services between Buffalo, NY, USA and Iowa, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Buffalo to Des Moines via Cleveland Bus Station, Chicago Bus Station, and Des Moines in around 19h 15m.

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