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How to get fromBuffalo to IowaBy plane, bus (Greyhound), train, bus, or car

Find Transport to Iowa

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There are 8 ways to get from Buffalo to Iowa by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Des Moines

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    5h 21m
    $263–1,349

  2. Fly to Quad City International Airport

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Quad City International Airport (MLI)plane plane BUF - MLI
    6h 45m
    $108–630

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    19h 30m
    $145–292

  4. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    19h 34m
    $207–505

  5. Drive 846.5 mi

    1. Drive from Buffalo to Des Moinescar car 846.5 mi
    14h 16m
    $155–224

  6. Fly to Omaha

    1. Fly from Buffalo Niagara International Airport (BUF) to Omaha (OMA)plane plane BUF - OMA
    5h 45m
    $291–1,358

  7. Fly to Waterloo Municipal Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Waterloo Municipal Airport (ALO)plane plane BUF - ALO
    6h 9m
    $133–699

  8. Train, bus via Bloomington

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Bloomington-Normaltrain train
    3. Take the bus from Bloomington-Normal to Des Moinesbus bus
    22h 28m
    $232–560

Buffalo Niagara International Airport (BUF) to Des Moines (DSM) flights

Calendar107Weekly Planes
Duration5h 28mAverage Duration
Ticket$242Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Iowa, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Buffalo to Des Moines via Cleveland Bus Station, Chicago Bus Station, and Des Moines in around 19h 30m.

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Need to know: Greyhound

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