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How to get fromBuffalo to Indianapolisby plane, bus (Greyhound), train, bus, car, shuttle, bus (Flixbus), or train (Amtrak)

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There are 8 ways to get from Buffalo to Indianapolis by plane, bus (Greyhound), train, bus, car, shuttle, bus (Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    5h 38m
    $128–730

  2. Bus via Toledo

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Indianapolis, INbus bus
    11h 5m
    $67–151

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit
    11h 56m
    $118–389

  4. Drive 495.5 mi

    1. Drive from Buffalo to Indianapoliscar car 495.5 mi
    8h 35m
    $91–131

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    7h 19m
    $141–696

  6. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    7h 30m
    $528–1,250

  7. Bus

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to Indianapolisbus bus FlixBus N2642 / ...
    15h 45m
    $101–303

  8. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $232–604

Buffalo to Indianapolis by bus

Calendar7Weekly Buses
Duration11h 5mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Indianapolis.ExpandLaunch map view
  • Distance: 476.3 mi
  • Duration: 5h 38m

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Buffalo to Indianapolis, IN via Cleveland Bus Station and Toledo in around 11h 5m.

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