Rome2Rio

How to get fromBuffalo to Indianapolisby plane, bus (Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

Find Transport to Indianapolis

See all options

There are 8 ways to get from Buffalo to Indianapolis by plane, bus (Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    6h 7m
    $94–554

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Buffalo to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to Indianapolisbus bus FlixBus 2511 / ...
    10h 55m
    $78–120

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit / ...
    11h 56m
    $98–368

  4. Drive  495.5 mi

    1. Drive from Buffalo to Indianapoliscar car 495.5 mi
    8h 34m
    $91–131

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    7h 25m
    $151–744

  6. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    7h 51m
    $338–1,061

  7. Bus via Brook Park (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Dayton Trotwood Bus Stationbus bus
    3. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    12h 25m
    $78–131

  8. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $182–563

Buffalo to Indianapolis by bus (Flixbus)

Calendar6Weekly Buses
Duration10h 55mAverage Duration
Ticket$78Cheapest Price
See schedules

Questions & Answers

Map of how to get from Buffalo to Indianapolis.ExpandLaunch map view
  • Distance: 478.1 mi
  • Duration: 6h 7m

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Buffalo to Indianapolis via Columbus in around 10h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers