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How to get fromBuffalo to Indianapolisby plane, train, bus, bus (Greyhound), car, shuttle, bus (Flixbus) or train (Amtrak)

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There are 8 ways to get from Buffalo to Indianapolis by plane, train, bus, bus (Greyhound), car, shuttle, bus (Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    5h 56m
    $116–732

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Cincinnati, OHbus bus Buffalo
    2. Take the bus from Cincinnati Bus Station to Indianapolis Union Stationbus bus Greyhound US0120
    13h 10m
    $66–130

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit
    11h 56m
    $95–279

  4. Drive 495.3 mi

    1. Drive from Buffalo to Indianapoliscar car 495.3 mi
    8h 27m
    $91–131

  5. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    7h 30m
    $266–682

  6. Bus to Rochester, fly

    1. Take the bus from Buffalo, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    8h 14m
    $206–737

  7. Bus via Pittsburgh

    1. Take the bus from Buffalo to Pittsburghbus bus Fab530
    2. Take the bus from Pittsburgh Intermodal Station to Indianapolisbus bus FlixBus N2640
    15h 45m
    $84–270

  8. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $104–344

Buffalo to Indianapolis by train and bus

Calendar7Weekly Services
Duration11h 56mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) every 3 hours. Alternatively, you can take a bus from Buffalo, NY to Indianapolis Union Station via Cincinnati, OH and Cincinnati Bus Station in around 13h 10m.

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