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How to get fromBuffalo to Indianapolisby bus (Flixbus), train, bus, car, plane, bus (Greyhound), or train (Amtrak)

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There are 7 ways to get from Buffalo to Indianapolis by bus (Flixbus), train, bus, car, plane, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Buffalo to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to Indianapolisbus bus FlixBus 2511 / ...
    10h 55m
    $83–124

  2. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolisbus bus Bsb 15
    11h 56m
    $183–448

  3. Drive  495.5 mi

    1. Drive from Buffalo to Indianapoliscar car 495.5 mi
    8h 34m
    $85–123

  4. Fly from Buffalo Niagara International Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    6h 42m
    $84–484

  5. Bus via Toledo (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    11h 20m
    $95–142

  6. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $382–753

  7. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    7h 50m
    $162–795

Buffalo to Indianapolis by bus (Flixbus)

Calendar8Weekly Buses
Duration10h 55mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Indianapolis.ExpandLaunch map view
  • Distance: 513.3 mi
  • Duration: 10h 55m

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

You can take a bus from Buffalo to Indianapolis via Columbus in around 10h 55m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) hourly.

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