There are 7 ways to get from Buffalo to Indianapolis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Indianapolis  •  5 h 46 min

  1. Fly from Buffalo (BUF) to Indianapolis (IND) BUF - IND

$164 - $448

Cheapest option

Bus  •  12 h 5 min

  1. Take the bus from Buffalo, NY to University of Cincinnati, OH Buffalo
  2. Take the bus from University of Cincinnati to Indianapolis, IN

$51 - $114

5 alternative options

Fly to Fort Wayne, bus  •  8 h 46 min

  1. Fly from Buffalo (BUF) to Fort Wayne (FWA) BUF - FWA
  2. Take the bus from Fort Wayne, IN to Indianapolis, IN

$151 - $725

Bus via Cleveland, Oh  •  12 h 13 min

  1. Take the bus from Buffalo, Ny to Cleveland, Oh 248
  2. Take the bus from Cleveland, Oh to Columbus, Oh
  3. Take the bus from Columbus, OH to Richmond, IN
  4. Take the bus from Richmond, IN to Indianapolis, IN

$71 - $160

Train  •  17 h 38 min

  1. Take the train from Buffalo Depew Station Amtrak to Chicago Union Station Lake Shore Limited
  2. Take the train from Chicago Union Station to Indianapolis Amtrak Hoosier State / ...

$134 - $368

Train, bus  •  20 h 14 min

  1. Take the train from Buffalo to Aldershot
  2. Take the train from Aldershot to London
  3. Take the bus from London, ON to Ann Arbor, MI
  4. Take the bus from Ann Arbor, MI to Indianapolis, IN

$101 - $287

Drive  •  8 h 26 min

  1. Drive from Buffalo to Indianapolis 503.2 miles

$45 - $75

Questions & Answers

No, there is no direct bus from Buffalo to Indianapolis. However, there are services departing from Buffalo, NY and arriving at Indianapolis, IN via University of Cincinnati. The journey, including transfers, takes approximately 12 h 5 min.

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No, there is no direct train from Buffalo to Indianapolis. However, there are services departing from Buffalo and arriving at Indianapolis Amtrak via Buffalo Depew Station Amtrak and Chicago Union Station. The journey, including transfers, takes approximately 17 h 38 min.

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The distance between Buffalo and Indianapolis is 437 miles. The road distance is 503.2 miles.

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The best way to get from Buffalo to Indianapolis without a car is to bus which takes 12 h 5 min and costs .

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It takes approximately 5 h 46 min to get from Buffalo to Indianapolis, including transfers.

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Buffalo to Indianapolis bus services, operated by Barons Bus, depart from Buffalo, NY station.

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Buffalo to Indianapolis train services, operated by Amtrak, arrive at Buffalo Depew Station Amtrak.

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The best way to get from Buffalo to Indianapolis is to fly which takes 5 h 46 min and costs . Alternatively, you can bus, which costs and takes 12 h 5 min, you could also train, which costs and takes 17 h 38 min.

Mode details

There is no direct flight from Buffalo Airport to Indianapolis Airport. The quickest flight takes 3 h 28 min and has one stopover.

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Buffalo to Indianapolis bus services, operated by Megabus, arrive at Indianapolis, IN station.

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Map of how to get from Buffalo to Indianapolis.
Launch map view
  • Distance: 437.1 miles
  • Duration: 5 h 46 min

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines and two other airlines fly from Buffalo to Indianapolis hourly. Alternatively, you can take a bus from Buffalo to Indianapolis via University of Cincinnati, OH and University of Cincinnati in around 12 h 5 min.

Airlines
United Airlines
Website
united.com
Flights from Buffalo to Indianapolis via Chicago O'Hare
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$170 - $750
Flights from Buffalo to Indianapolis via Washington Dulles
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$170 - $750
Flights from Buffalo to Fort Wayne via Chicago O'Hare
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$150 - $700
American Airlines
Website
aa.com
Flights from Buffalo to Indianapolis via Chicago O'Hare
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$170 - $850
Flights from Buffalo to Indianapolis via Reagan Washington
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$170 - $850
Flights from Buffalo to Indianapolis via Philadelphia
Ave. Duration
4 h 34 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Buffalo to Fort Wayne via Chicago O'Hare
Ave. Duration
5 h 3 min
When
Every day
Estimated price
$140 - $700
Flights from Buffalo to Fort Wayne via Philadelphia
Ave. Duration
6 h 26 min
When
Every day
Estimated price
$150 - $700
Flights from Buffalo to Fort Wayne via Dallas/Ft.Worth
Ave. Duration
7 h 50 min
When
Every day
Estimated price
$220 - $850
Flights from Buffalo to Fort Wayne via Charlotte
Ave. Duration
8 h 10 min
When
Monday, Tuesday, Thursday, Friday and Saturday
Estimated price
$160 - $750
Delta
Website
delta.com
Flights from Buffalo to Indianapolis via Detroit
Ave. Duration
3 h 40 min
When
Monday to Saturday
Estimated price
$170 - $700
Flights from Buffalo to Fort Wayne via Detroit
Ave. Duration
5 h
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$110 - $650
Flights from Buffalo to Fort Wayne via Atlanta
Ave. Duration
5 h 47 min
When
Every day
Estimated price
$160 - $750
Southwest Airlines
Website
southwest.com
Flights from Buffalo to Indianapolis via Chicago Midway
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$390 - $750
Flights from Buffalo to Indianapolis via Baltimore
Ave. Duration
4 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$390 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Buffalo Depew Station Amtrak to Chicago Union Station
Ave. Duration
10 h 30 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Train from Chicago Union Station to Indianapolis Amtrak
Ave. Duration
4 h 54 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Aldershot
Ave. Duration
3 h 38 min
Frequency
Every 3 hours
Estimated price
$25 - $75
Website
viarail.ca
Escape
$25 - $35
Economy
$30 - $45
Economy Plus
$50 - $75
Business
$45 - $65
Business Plus/Sleeper
$85 - $120
Train from Aldershot to London
Ave. Duration
1 h 32 min
Frequency
Every 30 minutes
Estimated price
$26 - $75
Website
viarail.ca
Escape
$26 - $40
Economy
$30 - $50
Economy Plus
$50 - $75
Business
$45 - $70
Business Plus/Sleeper
$85 - $130
Bus operators
Barons Bus
Phone
+1 888-378-3823
Website
baronsbus.com
Bus from Fort Wayne, IN to Indianapolis, IN
Ave. Duration
2 h 25 min
Frequency
Once daily
Estimated price
$16 - $30
Book at
baronsbus.com
Bus from Buffalo, NY to University of Cincinnati, OH
Ave. Duration
8 h 50 min
Frequency
Once daily
Estimated price
$35 - $95
Book at
baronsbus.com
Bus from Columbus, OH to Richmond, IN
Ave. Duration
2 h 10 min
Frequency
Once daily
Estimated price
$15 - $28
Book at
baronsbus.com
Bus from Richmond, IN to Indianapolis, IN
Ave. Duration
1 h 10 min
Frequency
Once daily
Estimated price
$13 - $25
Book at
baronsbus.com
Megabus
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to Cleveland, Oh
Ave. Duration
4 h 10 min
Frequency
Every 30 minutes
Estimated price
$24 - $60
Website
greyhound.com
Economy
$24 - $40
Flexible
$45 - $60
Bus from Cleveland, Oh to Columbus, Oh
Ave. Duration
2 h 25 min
Frequency
Every 30 minutes
Estimated price
$19 - $50
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $50
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from London, ON to Ann Arbor, MI
Ave. Duration
3 h 41 min
Frequency
Once daily
Estimated price
$20 - $50
Website
Greyhound.ca
Advanced Purchase
$20 - $29
Online Fare
$24 - $45
Standard Fare
$35 - $50
Refundable
$35 - $60

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More Questions & Answers

Buffalo to Indianapolis train services, operated by Amtrak, arrive at Indianapolis Amtrak station.

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Yes, the driving distance between Buffalo to Indianapolis is 503 miles. It takes approximately 8 h 26 min to drive from Buffalo to Indianapolis.

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Delta, American Airlines, Southwest Airlines and United Airlines offer flights from Buffalo Airport to Indianapolis Airport.

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There are 239+ hotels available in Indianapolis. Prices start at $69 USD per night.

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The best way to get from Buffalo to Buffalo Airport is to bus which takes 15 min and costs .

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