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How to get fromBuffalo to Indianapolisby plane, bus (Flixbus), train, bus, car, shuttle, bus (Greyhound) or train (Amtrak)

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There are 8 ways to get from Buffalo to Indianapolis by plane, bus (Flixbus), train, bus, car, shuttle, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    6h 6m
    $116–782

  2. Train, bus

    cheapest
    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit
    11h 56m
    $55–279

  3. Bus

    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus Buffalo
    2. Take the bus from Columbus to Indianapolisbus bus FlixBus N2640 / ...
    11h 49m
    $67–138

  4. Drive 495.5 mi

    1. Drive from Buffalo to Indianapoliscar car 495.5 mi
    8h 30m
    $91–131

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    8h 14m
    $206–687

  6. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    7h 30m
    $266–622

  7. Bus via Cleveland (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Dayton Trotwood Bus Stationbus bus
    3. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    13h 5m
    $96–193

  8. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $104–339

Buffalo to Indianapolis by bus

Calendar7Weekly Buses
Duration11h 49mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Indianapolis, IN, USA?

Delta, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) every 2 hours. Alternatively, you can take a bus from Buffalo, NY to Indianapolis via Columbus - Mound St, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 11h 49m.

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Need to know: Greyhound

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