• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 8 ways to get from Buffalo to Indiana by plane, bus, train, night bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Buffalo to Chicago O'Hare, bus  •  4 h 39 min

  1. Fly from Buffalo (BUF) to Chicago O'Hare (ORD) BUF - ORD
  2. Take the bus from Chicago O'Hare Airport to Highland, IN

$148 - $408

Cheapest option

Bus Barons Bus  •  12 h 5 min

  1. Take the bus from Buffalo, NY to University of Cincinnati, OH Buffalo
  2. Take the bus from University of Cincinnati to Indianapolis, IN

$51 - $114

6 alternative options

Fly Buffalo to Chicago Midway  •  5 h 5 min

  1. Fly from Buffalo (BUF) to Chicago Midway (MDW) BUF - MDW

$156 - $435

Train to Rochester, fly to Chicago O'Hare, bus  •  6 h 34 min

  1. Take the train from Buffalo Exchange Street Amtrak to Rochester Amtrak
  2. Fly from Rochester (ROC) to Chicago O'Hare (ORD) ROC - ORD
  3. Take the bus from Chicago O'Hare Airport to Highland, IN

$193 - $440

Night bus to Toronto, fly to Indianapolis  •  8 h 7 min

  1. Take the night bus from Buffalo, Ny to Toronto, On
  2. Fly from Toronto (YYZ) to Indianapolis (IND) YYZ - IND

$185 - $511

Train  •  17 h 38 min

  1. Take the train from Buffalo Depew Station Amtrak to Chicago Union Station Lake Shore Limited
  2. Take the train from Chicago Union Station to Indianapolis Amtrak Hoosier State / ...

$134 - $351

Bus via Ann Arbor, MI  •  20 h 46 min

  1. Take the bus from Niagara Falls, ON to Toronto, ON 252 / ...
  2. Take the bus from Toronto, ON to Ann Arbor, MI
  3. Take the bus from Ann Arbor, MI to Indianapolis, IN

$80 - $222

Drive  •  8 h 26 min

  1. Drive from Buffalo to Indianapolis 503.2 miles

$45 - $75

Questions & Answers

The cheapest way to get from Buffalo to Indiana is to drive which costs $45 - $75 and takes 8 h 26 min.

More details

The quickest way to get from Buffalo to Indiana is to fly and bus which costs $140 - $410 and takes 4 h 39 min.

More details

No, there is no direct bus from Buffalo to Indiana. However, there are services departing from Buffalo, NY and arriving at Indianapolis, IN via University of Cincinnati. The journey, including transfers, takes approximately 12 h 5 min.

More details

No, there is no direct train from Buffalo to Indiana. However, there are services departing from Buffalo Exchange Street Amtrak and arriving at Indianapolis Amtrak via Buffalo Depew Station Amtrak and Chicago Union Station. The journey, including transfers, takes approximately 17 h 38 min.

More details

The distance between Buffalo and Indiana is 419 miles. The road distance is 503.2 miles.

Get driving directions

The best way to get from Buffalo to Indiana without a car is to bus which takes 12 h 5 min and costs $50 - $120.

More details

It takes approximately 4 h 39 min to get from Buffalo to Indiana, including transfers.

More details

Buffalo to Indiana bus services, operated by Barons Bus, depart from Buffalo, NY station.

More details

Buffalo to Indiana train services, operated by Amtrak, arrive at Buffalo Depew Station Amtrak.

More details

The best way to get from Buffalo to Indiana is to fly which takes 5 h 5 min and costs $150 - $440. Alternatively, you can bus, which costs $50 - $120 and takes 12 h 5 min, you could also train, which costs $130 - $360 and takes 17 h 38 min.

Mode details

Map of how to get from Buffalo to Indiana.
Launch map view
  • Distance: 418.6 miles
  • Duration: 4 h 39 min

What companies run services between Buffalo, NY, USA and Indiana, USA?

Southwest Airlines and Delta fly from Buffalo to Hammond every 4 hours. Alternatively, you can take a bus from Buffalo to Indianapolis via University of Cincinnati, OH and University of Cincinnati in around 12 h 5 min.

Airlines
United Airlines
Website
united.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
2 h
When
Every day
Estimated price
$140 - $750
Flights from Buffalo to Chicago O'Hare via Washington Dulles
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$140 - $750
Flights from Rochester to Chicago O'Hare
Ave. Duration
2 h
When
Every day
Estimated price
$180 - $700
Flights from Rochester to Chicago O'Hare via Washington Dulles
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$180 - $700
Flights from Toronto to Indianapolis
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$200 - $1,400
Flights from Toronto to Indianapolis via Washington Dulles
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$210 - $1,000
Flights from Toronto to Indianapolis via Chicago O'Hare
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$210 - $1,000
Southwest Airlines
Website
southwest.com
Flights from Buffalo to Chicago Midway
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$160 - $750
Flights from Buffalo to Chicago Midway via Baltimore
Ave. Duration
4 h 15 min
When
Tuesday, Wednesday and Friday
Estimated price
$160 - $750
Air Canada
Website
aircanada.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
2 h
When
Every day
Estimated price
$140 - $750
Flights from Rochester to Chicago O'Hare
Ave. Duration
2 h
When
Every day
Estimated price
$180 - $700
Flights from Toronto to Indianapolis
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$200 - $1,400
Flights from Toronto to Indianapolis via Chicago O'Hare
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$210 - $1,000
American Airlines
Website
aa.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
2 h 5 min
When
Every day
Estimated price
$120 - $650
Flights from Rochester to Chicago O'Hare
Ave. Duration
2 h 6 min
When
Every day
Estimated price
$160 - $700
Flights from Toronto to Indianapolis via Chicago O'Hare
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$330 - $950
Delta
Website
delta.com
Flights from Buffalo to Chicago O'Hare via Detroit
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$130 - $800
Flights from Buffalo to Chicago Midway via Detroit
Ave. Duration
3 h 43 min
When
Monday to Saturday
Estimated price
$130 - $800
Flights from Rochester to Chicago O'Hare via Detroit
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$160 - $800
Flights from Toronto to Indianapolis via Detroit
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$220 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Buffalo Exchange Street Amtrak to Rochester Amtrak
Ave. Duration
1 h 8 min
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Buffalo Depew Station Amtrak to Chicago Union Station
Ave. Duration
10 h 30 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Train from Chicago Union Station to Indianapolis Amtrak
Ave. Duration
4 h 54 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Rochester
Ave. Duration
1 h 8 min
Frequency
Once daily
Estimated price
$40 - $85
Website
viarail.ca
Escape
$19 - $40
Economy
$40 - $55
EconomyPlus
$55 - $85
Business
$55 - $80
Bus operators
bus
Bus from Terminal 2, Chicago, IL - O'Hare Intl Airport to Highland, IN
Ave. Duration
1 h 5 min
Frequency
Hourly
Schedules at
airportsupersaver.com
Book at
airportsupersaver.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Night bus from Buffalo, Ny to Toronto, On
Ave. Duration
2 h 30 min
Frequency
Once daily
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40
Bus from Niagara Falls, On to Toronto, On
Ave. Duration
2 h 5 min
Frequency
3 times a day
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Megabus
Megabus Canada
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Niagara Falls, ON to Toronto, ON
Ave. Duration
2 h 10 min
Frequency
5 times a day
Estimated price
$13 - $35
Website
Greyhound.ca
Advanced Purchase
$13 - $19
Online Fare
$14 - $29
Standard Fare
$23 - $35
Refundable
$26 - $40
Bus from Toronto, ON to Ann Arbor, MI
Ave. Duration
6 h 19 min
Frequency
Once daily
Estimated price
$29 - $75
Website
Greyhound.ca
Advanced Purchase
$29 - $45
Online Fare
$35 - $60
Standard Fare
$50 - $75
Refundable
$55 - $80

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Buffalo Airport to Chicago O'Hare Airport is the direct flight which takes 1 h 52 min.

Search flights

Buffalo to Indiana bus services, operated by Megabus, arrive at Indianapolis, IN station.

More details

Buffalo to Indiana train services, operated by Amtrak, arrive at Indianapolis Amtrak station.

More details

Yes, the driving distance between Buffalo to Indiana is 503 miles. It takes approximately 8 h 26 min to drive from Buffalo to Indiana.

Get driving directions

American Airlines, Delta and United Airlines offer flights from Buffalo Airport to Chicago O'Hare Airport.

Search flights

Book your Buffalo to Indiana train tickets online with Rome2rio.

Search and book

There are 10+ hotels available in Indiana. Prices start at $100 USD per night.

More details

The best way to get from Buffalo to Buffalo Airport is to line 204 bus which takes 17 min and costs $2.

More details