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How to get fromBuffalo to Indianaby plane, train, bus (Flixbus), bus, car, bus (Greyhound), or train (Amtrak)

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There are 9 ways to get from Buffalo to Indiana by plane, train, bus (Flixbus), bus, car, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Chicago Midway International Airport, train

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    2. Take the train from Museum Campus/11th St. to Gary Metro Centertrain train
    4h 59m
    $172–327

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Buffalo to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to Indianapolisbus bus FlixBus 2511 / ...
    10h 55m
    $77–120

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit / ...
    11h 56m
    $93–367

  4. Drive  495.5 mi

    1. Drive from Buffalo to Indianapoliscar car 495.5 mi
    8h 34m
    $91–131

  5. Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    5h 17m
    $182–317

  6. Bus to Rochester, fly to Chicago Midway International Airport, train

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    3. Take the train from Museum Campus/11th St. to Gary Metro Centertrain train
    6h 17m
    $124–607

  7. Bus to Toronto Pearson International Airport, fly to Indianapolis

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    7h 51m
    $97–501

  8. Bus via Brook Park (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Dayton Trotwood Bus Stationbus bus
    3. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    12h 25m
    $77–130

  9. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 44m
    $177–562

Buffalo to Indiana by bus (Flixbus)

Calendar6Weekly Buses
Duration10h 55mAverage Duration
Ticket$77Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Indiana.ExpandLaunch map view
  • Distance: 518.6 mi
  • Duration: 4h 59m

What companies run services between Buffalo, NY, USA and Indiana, USA?

You can take a bus from Buffalo to Indianapolis via Columbus in around 10h 55m. Alternatively, you can take a train from Buffalo to Indianapolis via Buffalo Depew Station and Chicago Union Station in around 17h 44m.

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