There are 8 ways to get from Buffalo to Great Smoky Mountains National Park by plane, car, bus, taxi or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  6 h 18 min

  1. Fly from Buffalo (BUF) to Knoxville (TYS) BUF - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$193 - $925

Cheapest option

Bus, drive  •  22 h 45 min

  1. Take the bus from Buffalo, Ny to Cleveland, Oh 248
  2. Take the bus from Cleveland, Oh to Columbus, Oh
  3. Take the bus from Columbus, Oh to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$110 - $277

6 alternative options

Fly to Asheville, drive  •  6 h 45 min

  1. Fly from Buffalo (BUF) to Asheville (AVL) BUF - AVL
  2. Drive from Asheville to Great Smoky Mountains National Park

$205 - $978

Fly to Greenville/Spartanburg, drive  •  7 h 36 min

  1. Fly from Buffalo (BUF) to Greenville/Spartanburg (GSP) BUF - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains National Park

$182 - $837

Bus, Megabus, taxi  •  23 h 38 min

  1. Take the bus from Buffalo to Washington
  2. Take the Megabus from Washington to Knoxville
  3. Take a taxi from Mountain Grove SB before Majestic Grove to Great Smoky Mountains National Park

$305 - $392

Train, bus NYTN Bus, drive  •  23 h 46 min

  1. Take the train from Buffalo to Grand Central Terminal
  2. Take the bus from New York, NY to Knoxville, TN
  3. Drive from Knoxville, TN to Great Smoky Mountains National Park

$171 - $414

Train, bus, drive via Greensboro Galyon Transportation Center Amtrak  •  25 h 57 min

  1. Take the train from Buffalo Exchange Street Amtrak to New York Penn Station
  2. Take the train from New York Penn Station to Greensboro Galyon Transportation Center Amtrak
  3. Take the bus from Greensboro, Nc to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$180 - $475

Drive  •  11 h 39 min

  1. Drive from Buffalo to Great Smoky Mountains National Park 728.5 miles

$70 - $110

Questions & Answers

The cheapest way to get from Buffalo to Great Smoky Mountains National Park is to drive which costs $70 - $110 and takes 11 h 39 min.

More details

The quickest way to get from Buffalo to Great Smoky Mountains National Park is to fly and drive which costs $190 - $950 and takes 6 h 18 min.

More details

The distance between Buffalo and Great Smoky Mountains National Park is 564 miles. The road distance is 728.5 miles.

Get driving directions

It takes approximately 6 h 18 min to get from Buffalo to Great Smoky Mountains National Park, including transfers.

More details

What companies run services between Buffalo, NY, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Buffalo to Great Smoky Mountains National Park. However, you can take the bus to Buffalo Airport, take the walk to Buffalo airport, fly to Knoxville, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the bus to Buffalo Airport, take the walk to Buffalo airport, fly to Asheville, then take the drive to Great Smoky Mountains National Park.

Airlines
Delta
Website
delta.com
Flights from Buffalo to Knoxville via Detroit
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$180 - $900
Flights from Buffalo to Knoxville via Atlanta
Ave. Duration
4 h 54 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via New York La Guardia
Ave. Duration
4 h 51 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Atlanta
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Detroit, Atlanta
Ave. Duration
6 h 37 min
When
Every day
Estimated price
$200 - $1,000
Flights from Buffalo to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$170 - $850
Flights from Buffalo to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$160 - $800
Flights from Buffalo to Greenville/Spartanburg via New York La Guardia
Ave. Duration
5 h 44 min
When
Every day
Estimated price
$170 - $850
American Airlines
Website
aa.com
Flights from Buffalo to Knoxville via Reagan Washington
Ave. Duration
4 h 11 min
When
Monday to Saturday
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via Charlotte
Ave. Duration
4 h 32 min
When
Every day
Estimated price
$190 - $900
Flights from Buffalo to Knoxville via Philadelphia
Ave. Duration
4 h 56 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Knoxville via Chicago O'Hare
Ave. Duration
5 h 40 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $950
Flights from Buffalo to Asheville via Charlotte
Ave. Duration
4 h 32 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Philadelphia, Charlotte
Ave. Duration
6 h 59 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Buffalo to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$160 - $800
Flights from Buffalo to Greenville/Spartanburg via Philadelphia
Ave. Duration
4 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Buffalo to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 21 min
When
Monday to Saturday
Estimated price
$170 - $800
Flights from Buffalo to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5 h 32 min
When
Every day
Estimated price
$190 - $850
United Airlines
Website
united.com
Flights from Buffalo to Knoxville via Washington Dulles
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Knoxville via Newark
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$220 - $1,000
Flights from Buffalo to Knoxville via Chicago O'Hare
Ave. Duration
4 h 44 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,000
Flights from Buffalo to Asheville via Chicago O'Hare
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$230 - $1,100
Flights from Buffalo to Asheville via Newark
Ave. Duration
5 h 6 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,000
Flights from Buffalo to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$180 - $850
Flights from Buffalo to Greenville/Spartanburg via Newark
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$190 - $900
Flights from Buffalo to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5 h 28 min
When
Every day
Estimated price
$200 - $900
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Grand Central Terminal
Ave. Duration
9 h 5 min
Frequency
Every 3 hours
Estimated price
$60 - $200
Website
viarail.ca
Escape
$60 - $85
Economy
$100 - $140
Economy Plus
$140 - $200
Business
$150 - $210
Business Plus/Sleeper
$260 - $370
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Buffalo Exchange Street Amtrak to New York
Ave. Duration
8 h 10 min
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$300 - $410
Train from Buffalo Exchange Street Amtrak to New York Penn Station
Ave. Duration
8 h 15 min
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$300 - $410
Train from New York Penn Station to Greensboro Galyon Transportation Center Amtrak
Ave. Duration
10 h
Frequency
Twice daily
Estimated price
$75 - $210
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$130 - $200
Business Coach Seat
$150 - $210
Room
$320 - $450
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to Cleveland, Oh
Ave. Duration
3 h 15 min
Frequency
Hourly
Estimated price
$23 - $60
Website
greyhound.com
Economy
$23 - $40
Flexible
$40 - $60
Bus from Cleveland, Oh to Columbus, Oh
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$19 - $50
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $50
Bus from Columbus, Oh to Winston Salem, Nc
Ave. Duration
10 h 35 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Buffalo to Washington
Ave. Duration
11 h 20 min
Frequency
Once daily
Estimated price
$45 - $70
Schedules at
us.megabus.com
Bus from Washington to Knoxville
Ave. Duration
9 h 5 min
Frequency
Twice daily
Estimated price
$45 - $60
Schedules at
us.megabus.com
NYTN Bus
Website
nytnbus.com
Bus from New York, NY to Knoxville, TN
Ave. Duration
11 h 30 min
Frequency
Once daily
Estimated price
$100 - $200
Schedules at
nytnbus.com
Other operators
Taxi from Mountain Grove SB before Majestic Grove to Great Smoky Mountains National Park
Ave. Duration
1 h 26 min
Estimated price
$210 - $260
Knoxville Taxi Service
Phone
+1 865 691 1900
Website
knoxvilletaxicab.com

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Trips to Great Smoky Mountains National Park