There are 10 ways to get from Buffalo to Great Smoky Mountains National Park by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Buffalo to Knoxville, drive  •  6 h 38 min

  1. Fly from Buffalo (BUF) to Knoxville (TYS) BUF - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$187 - $775

Cheapest option

Bus, drive  •  23 h 37 min

  1. Take the bus from Buffalo, NY to Columbus, OH
  2. Take the bus from Columbus, Oh to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains National Park

$99 - $257

8 alternative options

Fly Buffalo to Asheville, drive  •  6 h 34 min

  1. Fly from Buffalo (BUF) to Asheville (AVL) BUF - AVL
  2. Drive from Asheville to Great Smoky Mountains National Park

$199 - $978

Fly Buffalo to Greenville/Spartanburg, drive  •  7 h 32 min

  1. Fly from Buffalo (BUF) to Greenville/Spartanburg (GSP) BUF - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains National Park

$175 - $837

Train to Rochester, fly to Knoxville, drive  •  8 h 38 min

  1. Take the train from Buffalo to Rochester
  2. Fly from Rochester (ROC) to Knoxville (TYS) ROC - TYS
  3. Drive from Knoxville to Great Smoky Mountains National Park

$221 - $1,030

Bus NYTN Bus, drive  •  21 h 40 min

  1. Take the bus from Buffalo, NY to New York, NY - Port Authority 207 / ...
  2. Take the bus from New York, NY to Knoxville, TN
  3. Drive from Knoxville, TN to Great Smoky Mountains National Park

$150 - $314

Train, bus NYTN Bus, drive  •  23 h 43 min

  1. Take the train from Buffalo to New York
  2. Take the bus from New York, NY to Knoxville, TN
  3. Drive from Knoxville, TN to Great Smoky Mountains National Park

$172 - $416

Bus, train, drive  •  25 h 47 min

  1. Take the bus from Buffalo to Washington
  2. Take the train from Washington Union Station to Greensboro Galyon Transportation Center
  3. Take the bus from Greensboro, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains National Park

$127 - $280

Train, bus, drive via Greensboro Galyon Transportation Center  •  26 h 47 min

  1. Take the train from Buffalo to New York
  2. Take the train from New York Penn Station to Greensboro Galyon Transportation Center
  3. Take the bus from Greensboro, Nc to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains National Park

$173 - $493

Drive  •  11 h 36 min

  1. Drive from Buffalo to Great Smoky Mountains National Park 731.8 miles

$70 - $110

Questions & Answers

The distance between Buffalo and Great Smoky Mountains National Park is 564 miles. The road distance is 731.8 miles.

Get driving directions

It takes approximately 6 h 38 min to get from Buffalo to Great Smoky Mountains National Park, including transfers.

More details

There is no direct flight from Buffalo Airport to Knoxville Airport. The quickest flight takes 3 h 46 min and has one stopover.

Search flights

Yes, the driving distance between Buffalo to Great Smoky Mountains National Park is 732 miles. It takes approximately 11 h 36 min to drive from Buffalo to Great Smoky Mountains National Park.

Get driving directions

Frontier Airlines, United Airlines, American Airlines and Delta offer flights from Buffalo Airport to Knoxville Airport.

Search flights

There are 1719+ hotels available in Great Smoky Mountains National Park. Prices start at $67 USD per night.

More details

The best way to get from Buffalo to Buffalo Airport is to bus which takes 15 min and costs .

More details

Map of how to get from Buffalo to Great Smoky Mountains National Park.
Launch map view
  • Distance: 564.1 miles
  • Duration: 6 h 38 min

What companies run services between Buffalo, NY, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Buffalo to Great Smoky Mountains National Park. However, you can take the bus to Buffalo Airport, take the walk to Buffalo airport, fly to Knoxville, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the bus to Buffalo Airport, take the walk to Buffalo airport, fly to Asheville, then take the drive to Great Smoky Mountains National Park.

Airlines
Delta
Website
delta.com
Flights from Buffalo to Knoxville via Detroit
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$180 - $900
Flights from Buffalo to Knoxville via Atlanta
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via New York La Guardia
Ave. Duration
5 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Atlanta
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Detroit, Atlanta
Ave. Duration
7 h 17 min
When
Monday to Friday
Estimated price
$200 - $1,000
Flights from Buffalo to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Buffalo to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$160 - $800
Flights from Buffalo to Greenville/Spartanburg via New York La Guardia
Ave. Duration
6 h 4 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Rochester to Knoxville via Detroit
Ave. Duration
4 h 22 min
When
Every day
Estimated price
$190 - $950
Flights from Rochester to Knoxville via Atlanta
Ave. Duration
4 h 38 min
When
Every day
Estimated price
$200 - $1,000
Flights from Rochester to Knoxville via New York La Guardia
Ave. Duration
5 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,000
American Airlines
Website
aa.com
Flights from Buffalo to Knoxville via Reagan Washington
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Knoxville via Charlotte
Ave. Duration
4 h 48 min
When
Every day
Estimated price
$190 - $900
Flights from Buffalo to Knoxville via Philadelphia
Ave. Duration
4 h 36 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Buffalo to Asheville via Charlotte
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Asheville via Reagan Washington, Charlotte
Ave. Duration
6 h 8 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Asheville via Philadelphia, Charlotte
Ave. Duration
6 h 31 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$160 - $800
Flights from Buffalo to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 19 min
When
Every day
Estimated price
$170 - $800
Flights from Buffalo to Greenville/Spartanburg via Philadelphia
Ave. Duration
5 h 4 min
When
Every day
Estimated price
$170 - $850
Flights from Buffalo to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
6 h 58 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $850
Flights from Rochester to Knoxville via Charlotte
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Knoxville via Reagan Washington
Ave. Duration
4 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,000
Flights from Rochester to Knoxville via Philadelphia
Ave. Duration
5 h 57 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Knoxville via Chicago O'Hare
Ave. Duration
6 h 25 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,000
United Airlines
Website
united.com
Flights from Buffalo to Knoxville via Washington Dulles
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$200 - $950
Flights from Buffalo to Knoxville via Chicago O'Hare
Ave. Duration
4 h 57 min
When
Monday to Saturday
Estimated price
$220 - $1,000
Flights from Buffalo to Knoxville via Newark
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$220 - $1,000
Flights from Buffalo to Asheville via Chicago O'Hare
Ave. Duration
5 h 33 min
When
Every day
Estimated price
$230 - $1,100
Flights from Buffalo to Asheville via Newark
Ave. Duration
4 h 48 min
When
Tuesday, Thursday and Sunday
Estimated price
$220 - $1,000
Flights from Buffalo to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$180 - $850
Flights from Buffalo to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5 h 19 min
When
Every day
Estimated price
$200 - $900
Flights from Buffalo to Greenville/Spartanburg via Newark
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$190 - $900
Flights from Rochester to Knoxville via Washington Dulles
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$210 - $1,000
Flights from Rochester to Knoxville via Newark
Ave. Duration
5 h 26 min
When
Every day
Estimated price
$230 - $1,100
Flights from Rochester to Knoxville via Chicago O'Hare
Ave. Duration
5 h 35 min
When
Every day
Estimated price
$240 - $1,100
Frontier Airlines
Website
flyfrontier.com
Flights from Buffalo to Knoxville via Orlando
Ave. Duration
5 h 33 min
When
Monday and Friday
Estimated price
$180 - $750
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Rochester
Ave. Duration
1 h 8 min
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$50 - $70
Business
$45 - $65
Business Plus/Sleeper
$80 - $120
Train from Buffalo to New York
Ave. Duration
9 h 5 min
Frequency
Every 3 hours
Estimated price
$60 - $210
Website
viarail.ca
Escape
$60 - $85
Economy
$100 - $140
Economy Plus
$140 - $210
Business
$150 - $210
Business Plus/Sleeper
$270 - $380
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Buffalo Exchange Street Amtrak to Rochester Amtrak
Ave. Duration
1 h 8 min
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Buffalo Exchange Street Amtrak to New York Penn Station
Ave. Duration
8 h 15 min
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$300 - $410
Train from Washington Union Station to Greensboro Galyon Transportation Center
Ave. Duration
5 h 45 min
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $330
Train from New York Penn Station to Greensboro Galyon Transportation Center
Ave. Duration
10 h
Frequency
Twice daily
Estimated price
$75 - $210
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$130 - $200
Business Coach Seat
$150 - $210
Room
$320 - $450
Bus operators
Trailways New York
Phone
(800) 858-8555
Website
trailwaysny.com
Bus from Buffalo, NY to New York, NY - Port Authority
Ave. Duration
7 h
Frequency
Every 2 hours
Estimated price
$50 - $100
Book at
trailwaysny.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to New York, Ny
Ave. Duration
9 h 15 min
Frequency
Every 15 minutes
Estimated price
$40 - $100
Website
greyhound.com
Economy
$40 - $65
Flexible
$75 - $100
Bus from Columbus, Oh to Winston Salem, Nc
Ave. Duration
10 h 35 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Greensboro, Nc to Asheville, Nc
Ave. Duration
4 h 10 min
Frequency
Every 2 hours
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
NYTN Bus
Website
nytnbus.com
Bus from New York, NY to Knoxville, TN
Ave. Duration
11 h 30 min
Frequency
Once daily
Estimated price
$100 - $200
Schedules at
nytnbus.com
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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Trips to Great Smoky Mountains National Park