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How to get fromBuffalo to Durhamby plane, bus, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

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There are 8 ways to get from Buffalo to Durham by plane, bus, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Raleigh-Durham International Airport, line 700 bus

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU)plane plane BUF - RDU
    2. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    4h 27m
    $112–634

  2. Bus to Rochester, fly to Raleigh-Durham International Airport

    cheapest
    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Raleigh-Durham International Airport (RDU)plane plane ROC - RDU
    5h 57m
    $104–800

  3. Bus (Flixbus)

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York Midtown to Durhambus bus FlixBus N2471 / ...
    19h 50m
    $133–226

  4. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Durham Amtrak Stationtrain train Carolinian
    22h 8m
    $311–640

  5. Drive 576.7 mi

    1. Drive from Buffalo to Durhamcar car 576.7 mi
    12h 38m
    $106–152

  6. Fly Buffalo Niagara International Airport to Piedmont Triad International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO)plane plane BUF - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 10m
    $192–948

  7. Bus via New York

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from Port Authority Bus Terminal to Durhambus bus Greyhound US0670
    22h 5m
    $137–408

  8. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Carytrain train Floridian
    24h 58m
    $247–609

Buffalo to Durham by bus (Flixbus)

Calendar17Weekly Buses
Duration19h 50mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Durham.ExpandLaunch map view
  • Distance: 515.2 mi
  • Duration: 4h 27m

What companies run services between Buffalo, NY, USA and Durham, NC, USA?

You can take a bus from Buffalo to Durham via New York Midtown in around 19h 50m. Alternatively, you can take a train from Buffalo to Durham Amtrak Station via Ny Moynihan Train Hall At Penn Station in around 22h 8m.

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