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How to get fromBuffalo to Durhamby plane, bus, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

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There are 8 ways to get from Buffalo to Durham by plane, bus, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU)plane plane BUF - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 41m
    $128–428

  2. Drive  576.6 mi

    cheapest
    1. Drive from Buffalo to Durhamcar car 576.6 mi
    12h 35m
    $106–152

  3. Bus (Flixbus)

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York Midtown to Durhambus bus FlixBus N2471 / ...
    20h
    $149–232

  4. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Durham Amtrak Stationtrain train Carolinian
    22h 8m
    $253–569

  5. Bus to Rochester, fly to Raleigh-Durham International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Raleigh-Durham International Airport (RDU)plane plane ROC - RDU
    5h 50m
    $155–947

  6. Fly Buffalo Niagara International Airport to Piedmont Triad International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO)plane plane BUF - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 34m
    $175–822

  7. Bus via New York

    1. Take the bus from Buffalo to New Yorkbus bus Adt N813 / ...
    2. Take the bus from Port Authority Bus Terminal to Durhambus bus Greyhound US0670
    22h 15m
    $147–413

  8. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train Floridian
    24h 24m
    $204–556

Buffalo to Durham by bus (Flixbus)

Calendar16Weekly Buses
Duration20hAverage Duration
Ticket$149Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Durham.ExpandLaunch map view
  • Distance: 516.6 mi
  • Duration: 4h 41m

What companies run services between Buffalo, NY, USA and Durham, NC, USA?

You can take a bus from Buffalo to Durham via New York Midtown in around 20h. Alternatively, you can take a train from Buffalo to Durham Amtrak Station via Ny Moynihan Train Hall At Penn Station in around 22h 8m.

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