Rome2Rio

How to get fromBuffalo to Durhamby plane, bus (Flixbus), train (Amtrak), car, bus, train, or bus (Greyhound)

Find Transport to Durham

See all options

There are 9 ways to get from Buffalo to Durham by plane, bus (Flixbus), train (Amtrak), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Raleigh-Durham International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU)plane plane BUF - RDU
    6h 19m
    $128–238

  2. Drive  576.7 mi

    cheapest
    1. Drive from Buffalo to Durhamcar car 576.7 mi
    12h 35m
    $106–152

  3. Bus (Flixbus)

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York Midtown to Durhambus bus FlixBus N2471 / ...
    19h 50m
    $150–226

  4. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Durham Amtrak Stationtrain train Carolinian
    22h 8m
    $542–852

  5. Bus to Rochester, fly to Raleigh-Durham International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Raleigh-Durham International Airport (RDU)plane plane ROC - RDU
    5h 50m
    $146–749

  6. Fly Buffalo Niagara International Airport to Piedmont Triad International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO)plane plane BUF - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 26m
    $126–477

  7. Bus to Toronto Pearson International Airport, fly to Raleigh-Durham International Airport

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Raleigh-Durham International Airport (RDU)plane plane YYZ - RDU
    8h 21m
    $107–495

  8. Bus via New York

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from Port Authority Bus Terminal to Durhambus bus Greyhound US0670
    22h 25m
    $152–398

  9. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train Floridian
    24h 24m
    $374–716

Buffalo to Durham by bus (Flixbus)

Calendar16Weekly Buses
Duration19h 50mAverage Duration
Ticket$150Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Durham.ExpandLaunch map view
  • Distance: 516.6 mi
  • Duration: 6h 19m

What companies run services between Buffalo, NY, USA and Durham, NC, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU) hourly. Alternatively, you can take a bus from Buffalo to Durham via New York Midtown in around 19h 50m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There