• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 6 ways to get from Buffalo to Des Moines by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Des Moines  •  6 h 44 min

  1. Fly from Buffalo (BUF) to Des Moines (DSM) BUF - DSM

$154 - $424

Cheapest option

Bus  •  26 h 30 min

  1. Take the bus from Buffalo, NY to Toronto, ON 300 / ...
  2. Take the bus from Toronto, ON to Chicago, IL
  3. Take the bus from Chicago, IL to Des Moines, IA

$96 - $246

4 alternative options

Fly to Waterloo, bus  •  12 h 27 min

  1. Fly from Buffalo (BUF) to Waterloo (ALO) BUF - ALO
  2. Take the bus from Waterloo, IA to Des Moines, IA

$251 - $986

Bus, Megabus  •  19 h 1 min

  1. Take the bus from Buffalo, Ny to Cleveland, Oh 248
  2. Take the Megabus from Cleveland to Chicago, IL
  3. Take the bus from Chicago, IL to Des Moines, IA

Train, bus  •  20 h 17 min

  1. Take the train from Buffalo Depew Station Amtrak to Chicago Union Station
  2. Take the train from Chicago Union Station to Ottumwa Amtrak
  3. Take the bus from Ottumwa, IA to Des Moines, IA

$173 - $426

Drive  •  14 h 1 min

  1. Drive from Buffalo to Des Moines 855.7 miles

$80 - $130

Questions & Answers

The cheapest way to get from Buffalo to Des Moines is to drive which costs $80 - $130 and takes 14 h 1 min.

More details

The quickest way to get from Buffalo to Des Moines is to fly which costs $150 - $430 and takes 6 h 44 min.

More details

No, there is no direct bus from Buffalo to Des Moines. However, there are services departing from Buffalo, Ny and arriving at Des Moines, IA via Chester Av & E 15Th St, Cleveland and Chicago, IL. The journey, including transfers, takes approximately 19 h 1 min.

More details

The distance between Buffalo and Des Moines is 762 miles. The road distance is 855.7 miles.

Get driving directions

The best way to get from Buffalo to Des Moines without a car is to bus and Megabus which takes 19 h 1 min and costs .

More details

It takes approximately 6 h 44 min to get from Buffalo to Des Moines, including transfers.

More details

Buffalo to Des Moines bus services, operated by Greyhound USA, depart from Buffalo, Ny station.

More details

The best way to get from Buffalo to Des Moines is to fly which takes 6 h 44 min and costs $150 - $430. Alternatively, you can bus and Megabus, which costs and takes 19 h 1 min.

Mode details

There is no direct flight from Buffalo Airport to Des Moines Airport. The quickest flight takes 4 h 11 min and has one stopover.

Search flights

Buffalo to Des Moines bus services, operated by Windstar, arrive at Des Moines, IA station.

More details

Map of how to get from Buffalo to Des Moines.
Launch map view
  • Distance: 762.1 miles
  • Duration: 6 h 44 min

What companies run services between Buffalo, NY, USA and Des Moines, IA, USA?

United Airlines, Delta and two other airlines fly from Buffalo to Des Moines hourly. Alternatively, you can take a bus from Buffalo to Des Moines via Cleveland, Oh, Chester Av & E 15Th St, Stephanie Tubbs Jones Transit Center Stop #9, Cleveland, and Chicago, IL in around 19 h 1 min.

Airlines
American Airlines
Website
aa.com
Flights from Buffalo to Des Moines via Chicago O'Hare
Ave. Duration
5 h 16 min
When
Every day
Estimated price
$300 - $1,300
Flights from Buffalo to Des Moines via Charlotte
Ave. Duration
6 h 14 min
When
Every day
Estimated price
$300 - $1,300
Flights from Buffalo to Des Moines via Reagan Washington
Ave. Duration
7 h 3 min
When
Every day
Estimated price
$300 - $1,300
Flights from Buffalo to Des Moines via Philadelphia
Ave. Duration
7 h 18 min
When
Every day
Estimated price
$300 - $1,300
Flights from Buffalo to Waterloo via Chicago O'Hare
Ave. Duration
6 h 7 min
When
Every day
Estimated price
$190 - $950
Flights from Buffalo to Waterloo via Philadelphia, Chicago O'Hare
Ave. Duration
9 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,000
Flights from Buffalo to Waterloo via Reagan Washington, Chicago O'Hare
Ave. Duration
9 h 36 min
When
Every day
Estimated price
$220 - $1,000
Delta
Website
delta.com
Flights from Buffalo to Des Moines via Detroit
Ave. Duration
5 h 9 min
When
Every day
Estimated price
$420 - $900
Flights from Buffalo to Des Moines via Atlanta
Ave. Duration
6 h 18 min
When
Every day
Estimated price
$420 - $900
Flights from Buffalo to Des Moines via New York La Guardia
Ave. Duration
6 h 56 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$420 - $900
Flights from Buffalo to Des Moines via Minneapolis
Ave. Duration
6 h 27 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$420 - $900
United Airlines
Website
united.com
Flights from Buffalo to Des Moines via Chicago O'Hare
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$310 - $1,200
Frontier Airlines
Website
flyfrontier.com
Flights from Buffalo to Des Moines via Denver
Ave. Duration
7 h 45 min
When
Monday and Friday
Estimated price
$180 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Buffalo Depew Station Amtrak to Chicago Union Station
Ave. Duration
10 h 30 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Train from Chicago Union Station to Ottumwa Amtrak
Ave. Duration
4 h 53 min
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Burlington Trailways
Website
burlingtontrailways.com
Bus from Waterloo, IA to Des Moines, IA
Ave. Duration
5 h 15 min
Frequency
Once daily
Estimated price
$40 - $60
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Ottumwa, IA to Des Moines, IA
Ave. Duration
1 h 40 min
Frequency
Once daily
Estimated price
$29 - $45
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
11 h 25 min
Frequency
Once daily
Estimated price
$40 - $90
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to Cleveland, Oh
Ave. Duration
3 h 15 min
Frequency
4 times a day
Estimated price
$23 - $60
Website
greyhound.com
Economy
$23 - $40
Flexible
$40 - $60
Bus from Buffalo, Ny to Toronto, On
Ave. Duration
2 h 45 min
Frequency
4 times a day
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Cleveland to Chicago, IL
Ave. Duration
6 h 40 min
Frequency
Twice daily
Estimated price
$30 - $50
Book at
megabus.com
Bus from Buffalo, NY to Toronto, ON
Ave. Duration
2 h 20 min
Frequency
3 times a day
Estimated price
$11 - $21
Book at
megabus.com
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
6 h 40 min
Frequency
Once daily
Schedules at
gowindstar.com
Megabus Canada
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Buffalo, NY to Toronto, ON
Ave. Duration
3 h 15 min
Frequency
5 times a day
Estimated price
$14 - $40
Website
Greyhound.ca
Advanced Purchase
$14 - $21
Online Fare
$16 - $35
Standard Fare
$25 - $40
Refundable
$29 - $45
Bus from Toronto, ON to Chicago, IL
Ave. Duration
10 h 45 min
Frequency
4 times a day
Estimated price
$45 - $120
Website
Greyhound.ca
Advanced Purchase
$45 - $70
Online Fare
$60 - $90
Standard Fare
$75 - $120
Refundable
$85 - $130

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Des Moines is 1 h behind Buffalo. It is currently 3:55 AM in Buffalo and 2:55 AM in Des Moines.

Yes, the driving distance between Buffalo to Des Moines is 856 miles. It takes approximately 14 h 1 min to drive from Buffalo to Des Moines.

Get driving directions

Frontier Airlines, United Airlines, Delta and American Airlines offer flights from Buffalo Airport to Des Moines Airport.

Search flights

There are 105+ hotels available in Des Moines. Prices start at $75 USD per night.

More details

The best way to get from Buffalo to Buffalo Airport is to line 204 bus which takes 17 min and costs $2.

More details