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How to get fromBuffalo to Defianceby bus (Greyhound, Amtrak), train (Amtrak), car, plane, taxi, or bus (Amtrak)

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There are 5 ways to get from Buffalo to Defiance by bus (Greyhound, Amtrak), train (Amtrak), car, plane, taxi, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Bryan Amtrak Stationbus bus
    8h 20m
    $120–184

  2. Drive 339.1 mi

    cheapest
    1. Drive from Buffalo to Defiancecar car 339.1 mi
    6h 20m
    $62–90

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    8h 31m
    $167–434

  4. Fly, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA)plane plane BUF - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    6h 33m
    $221–668

  5. Bus via Akron

    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland, OHbus bus
    3. Take the bus from Cleveland to Toledobus bus
    4. Take the bus from Toledo to Bryan Amtrak Stationbus bus
    10h 45m
    $111–241

Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA) flights

Calendar106Weekly Planes
Duration6h 6mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Defiance.ExpandLaunch map view
  • Distance: 383.2 mi
  • Duration: 8h 20m

What companies run services between Buffalo, NY, USA and Defiance, OH, USA?

You can take a bus from Buffalo to Defiance via Cleveland Bus Station, Toledo, and Bryan Amtrak Station in around 8h 20m. Alternatively, Amtrak operates a train from Buffalo Depew Station to Bryan Amtrak Station twice daily. Tickets cost $110–230 and the journey takes 6h 44m.

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