Rome2Rio

How to get fromBuffalo to Defianceby train (Amtrak), bus, train, car, plane or taxi

Find Transport to Defiance

See all options

There are 4 ways to get from Buffalo to Defiance by train (Amtrak), bus, train, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Buffalo Depew Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    8h 31m
    $149–334

  2. Drive 339.8 mi

    cheapest
    1. Drive from Buffalo to Defiancecar car 339.8 mi
    6h 18m
    $62–90

  3. Bus, train

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the train from Toledo to Bryan Amtrak Stationtrain train
    8h 55m
    $111–203

  4. Fly, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA)plane plane BUF - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    5h 20m
    $231–758

Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA) flights

Calendar62Weekly Planes
Duration5h 13mAverage Duration
Ticket$85Cheapest Price
See schedules

Questions & Answers

What companies run services between Buffalo, NY, USA and Defiance, OH, USA?

Amtrak operates a train from Buffalo Depew Station to Bryan Amtrak Station twice daily. Tickets cost $85–190 and the journey takes 6h 44m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Buffalo

Trips to Defiance

Popular routes