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How to get fromBuffalo to Defianceby train (Amtrak), bus (Amtrak), car, plane, taxi, or bus (Greyhound, Flixbus, Amtrak)

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There are 5 ways to get from Buffalo to Defiance by train (Amtrak), bus (Amtrak), car, plane, taxi, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Buffalo Depew Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    8h 31m
    $167–436

  2. Drive 339.1 mi

    cheapest
    1. Drive from Buffalo to Defiancecar car 339.1 mi
    6h 20m
    $62–90

  3. Bus

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Bryan Amtrak Stationbus bus
    8h 50m

  4. Fly, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA)plane plane BUF - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    6h 29m
    $212–648

  5. Bus via Akron

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Bryan Amtrak Stationbus bus
    11h 15m

Buffalo Niagara International Airport (BUF) to Fort Wayne International Airport (FWA) flights

Calendar96Weekly Planes
Duration5h 52mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Defiance.ExpandLaunch map view
  • Distance: 374 mi
  • Duration: 8h 31m

What companies run services between Buffalo, NY, USA and Defiance, OH, USA?

Amtrak operates a train from Buffalo Depew Station to Bryan Amtrak Station twice daily. Tickets cost $110–230 and the journey takes 6h 44m. Alternatively, you can take a bus from Buffalo to Defiance via Cleveland Bus Station, Toledo, and Bryan Amtrak Station in around 8h 50m.

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