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How to get fromBuffalo to Chicagoby plane, bus (Greyhound), train (Amtrak), car, or bus

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Buffalo to Chicago

Rome2Rio compared 7 ways to get from Buffalo to Chicago. The best route is Fly Buffalo Niagara International Airport to Chicago Midway International Airport, a distance of 727.026 km.

  1. Fly Buffalo Niagara International Airport to Chicago Midway International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    3h 26m
    $98–583

  2. Bus via Akron

    cheapest
    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland, OHbus bus
    3. Take the bus from Cleveland to Chicagobus bus
    14h 15m
    $60–181

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    11h 40m
    $80–150

  4. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    11h 50m
    $172–474

  5. Drive 530.8 mi

    1. Drive from Buffalo to Chicagocar car 530.8 mi
    9h 3m
    $97–140

  6. Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    3h 54m
    $78–443

  7. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 6m
    $106–499

Buffalo to Chicago by bus (Greyhound)

Calendar14Weekly Buses
Duration11h 40mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Chicago.ExpandLaunch map view
  • Distance: 488.1 mi
  • Duration: 3h 26m

What companies run services between Buffalo, NY, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, you can take a bus from Buffalo to Chicago Bus Station via Cleveland Bus Station in around 11h 40m.

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