There are 6 ways to get from Buffalo to Chicago by plane, train (Amtrak), bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Chicago Midway International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
3h 31m$118–733Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport
cheapest- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
3h 53m$83–493Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 50m$149–405Bus (Greyhound)
- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
11h 55m$90–185Drive 531.6 mi
- Drive from Buffalo to Chicagocar 531.6 mi
9h 1m$97–141Bus to Rochester, fly to Chicago Midway International Airport
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
5h 11m$120–602
Buffalo to Chicago by train (Amtrak)
Questions & Answers
The cheapest way to get from Buffalo to Chicago is to bus which costs $85 - $190 and takes 11h 55m.
The fastest way to get from Buffalo to Chicago is to fly which takes 3h 31m and costs $110 - $750.
No, there is no direct bus from Buffalo to Chicago station. However, there are services departing from Buffalo and arriving at Chicago Bus Station via Cleveland Bus Station. The journey, including transfers, takes approximately 11h 55m.
No, there is no direct train from Buffalo to Chicago station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 50m.
The distance between Buffalo and Chicago is 491 miles. The road distance is 534.7 miles.
The best way to get from Buffalo to Chicago without a car is to train which takes 11h 50m and costs $140 - $410.
It takes approximately 3h 31m to get from Buffalo to Chicago, including transfers.
Buffalo to Chicago bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Chicago train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Chicago is to fly which takes 3h 31m and costs $110 - $750. Alternatively, you can train, which costs $140 - $410 and takes 11h 50m, you could also bus, which costs $85 - $190 and takes 11h 55m.
What companies run services between Buffalo, NY, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $140–330 and the journey takes 10h 33m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $110–700
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 10m
- When
- Monday, Thursday, and Friday
- Estimated price
- $160–850
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- $90–550
Flights from Rochester to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $130–700
- Website
- united.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- $75–460
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- $110–700
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $75–460
Flights from Rochester to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 34m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–550
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 8m
- When
- Every day
- Estimated price
- $75–460
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $140–330
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 40m
- Frequency
- Twice daily
- Estimated price
- $55–120
- Website
- https://www.greyhound.com/
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- 4 times a day
- Estimated price
- $13–25
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- $10–17
- Schedules at
- flixbus.com
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More Questions & Answers
Buffalo to Chicago bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago is 1h behind Buffalo. It is currently 4:54 AM in Buffalo and 3:54 AM in Chicago.
Buffalo to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Chicago is 535 miles. It takes approximately 9h 1m to drive from Buffalo to Chicago.
Book your Buffalo to Chicago train tickets online with Omio.
Book your Buffalo to Chicago bus tickets online with FlixBus.
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