There are 7 ways to get from Buffalo to Chicago by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Buffalo to Chicago Midway  •  3 h 25 min

  1. Fly from Buffalo (BUF) to Chicago Midway (MDW) BUF - MDW

$140 - $420

Cheapest option

Bus  •  15 h 25 min

  1. Take the bus from Buffalo, Ny to Toronto, On 300 / ...
  2. Take the bus from Toronto, On to Chicago, Il 5515

$61 - $176

5 alternative options

Fly Buffalo to Chicago O'Hare  •  3 h 45 min

  1. Fly from Buffalo (BUF) to Chicago O'Hare (ORD) BUF - ORD

$130 - $391

Train to Rochester, fly to Chicago O'Hare  •  5 h 48 min

  1. Take the train from Buffalo to Rochester
  2. Fly from Rochester (ROC) to Chicago O'Hare (ORD) ROC - ORD

$168 - $426

Train  •  11 h 44 min

  1. Take the train from Buffalo Depew Station Amtrak to Chicago Union Station Lake Shore Limited

$94 - $269

Train, bus  •  17 h 2 min

  1. Take the train from Buffalo to Toronto VIA Rail
  2. Take the bus from Toronto, ON to Chicago - Amtrak 5531

$77 - $208

Drive  •  8 h 55 min

  1. Drive from Buffalo to Chicago 535.9 miles

$50 - $80

Questions & Answers

The cheapest way to get from Buffalo to Chicago is to drive which costs $50 - $80 and takes 8 h 55 min.

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The quickest way to get from Buffalo to Chicago is to fly which costs $140 - $420 and takes 3 h 25 min.

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No, there is no direct bus from Buffalo to Chicago. However, there are services departing from Buffalo, Ny and arriving at Chicago, Il via Toronto, On. The journey, including transfers, takes approximately 15 h 25 min.

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No, there is no direct train from Buffalo to Chicago station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station Amtrak. The journey, including transfers, takes approximately 11 h 44 min.

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The distance between Buffalo and Chicago is 454 miles. The road distance is 535.9 miles.

Get driving directions

The best way to get from Buffalo to Chicago without a car is to train which takes 11 h 44 min and costs $90 - $270.

More details

It takes approximately 3 h 25 min to get from Buffalo to Chicago, including transfers.

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Buffalo to Chicago bus services, operated by Greyhound USA, depart from Buffalo, Ny station.

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Map of how to get from Buffalo to Chicago.
Launch map view
  • Distance: 454.4 miles
  • Duration: 3 h 25 min

What companies run services between Buffalo, NY, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Buffalo to Chicago every 4 hours. Alternatively, Amtrak operates a train from Buffalo to Chicago twice daily. Tickets cost $75 - $220 and the journey takes 10 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Buffalo to Chicago Midway
Ave. Duration
1 h 38 min
When
Every day
Estimated price
$160 - $750
Flights from Buffalo to Chicago Midway via Baltimore
Ave. Duration
4 h 3 min
When
Saturday and Sunday
Estimated price
$160 - $750
United Airlines
Website
united.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$140 - $750
Flights from Buffalo to Chicago O'Hare via Washington Dulles
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$140 - $750
Flights from Rochester to Chicago O'Hare
Ave. Duration
1 h 54 min
When
Every day
Estimated price
$180 - $700
Air Canada
Website
aircanada.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$140 - $750
Flights from Rochester to Chicago O'Hare
Ave. Duration
1 h 53 min
When
Every day
Estimated price
$180 - $700
Flights from Rochester to Chicago O'Hare via Toronto
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$140 - $600
Delta
Website
delta.com
Flights from Buffalo to Chicago Midway via Detroit
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$130 - $800
Flights from Buffalo to Chicago O'Hare via Detroit
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$130 - $800
Flights from Rochester to Chicago O'Hare via Detroit
Ave. Duration
3 h 41 min
When
Every day
Estimated price
$160 - $800
American Airlines
Website
aa.com
Flights from Buffalo to Chicago O'Hare
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$120 - $650
Flights from Rochester to Chicago O'Hare
Ave. Duration
1 h 58 min
When
Every day
Estimated price
$160 - $700
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Buffalo to Rochester
Ave. Duration
1 h 8 min
Frequency
Every 3 hours
Estimated price
$25 - $75
Website
viarail.ca
Escape
$25 - $35
Economy
$30 - $45
Economy Plus
$50 - $75
Business
$45 - $65
Business Plus/Sleeper
$80 - $120
Train from Buffalo to Toronto
Ave. Duration
4 h 17 min
Frequency
Every 3 hours
Estimated price
$29 - $85
Website
viarail.ca
Escape
$29 - $40
Economy
$40 - $55
Economy Plus
$60 - $85
Business
$55 - $80
Business Plus/Sleeper
$100 - $150
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Buffalo Exchange Street Amtrak to Rochester Amtrak
Ave. Duration
1 h 8 min
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Buffalo Depew Station Amtrak to Chicago Union Station
Ave. Duration
10 h 30 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to Toronto, On
Ave. Duration
2 h 45 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40
Bus from Toronto, On to Chicago, Il
Ave. Duration
11 h 45 min
Frequency
Hourly
Estimated price
$50 - $140
Website
greyhound.com
Economy
$50 - $85
Flexible
$100 - $140
Megabus Canada
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Toronto, ON to Chicago - Amtrak
Ave. Duration
11 h 35 min
Frequency
Once daily
Estimated price
$45 - $120
Website
Greyhound.ca
Advanced Purchase
$45 - $70
Online Fare
$60 - $90
Standard Fare
$75 - $120
Refundable
$85 - $130

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