Travel options for:
Buffalo to Chicago
  • Fly to Chicago Midway

    $134 - $427
    1. Buffalo

      40 min - hourly

      $2 - $23

    2. Buffalo (BUF)

      1 h 40 min - non-stop

      $130 - $400

    3. Chicago Midway (MDW)

      24 min - every 15 minutes

      $2 - $4

  • Fly to Chicago O'Hare

    $124 - $398
    1. Buffalo

      40 min - hourly

      $2 - $23

    2. Buffalo (BUF)

      1 h 51 min - non-stop

      $120 - $370

    3. Chicago O'Hare (ORD)

      42 min - every 10 minutes

      $2 - $5

  • Train

    $96 - $249
    1. Buffalo

      18 min - every 3 hours

      $21 - $30

    2. Buffalo Depew Station Amtrak

      10 h 46 min - once daily

      $75 - $220

  • Bus Greyhound Canada

    $57 - $161
    1. Buffalo, NY

      2 h 10 min - 3 times a day

      $11 - $45

    2. Toronto, ON

      10 h 45 min - once daily

      $45 - $120

  • Bus Greyhound USA

    $65 - $162
    1. Buffalo, NY

      4 h 40 min - once daily

      $24 - $45

    2. Akron, OH

      9 h 13 min - once daily

      $40 - $120

  • Drive

    $50 - $80
    1. Buffalo

      8 h 53 min - 536.3 miles

      $50 - $80

  • Accommodation
  • Best Price Guarantee
  • Car Hire
  • Compare Best Rates
  • Things to do
  • View attractions

From Ellicott St & North Division St bus to Buffalo airport, fly to Chicago Midway airport, then subway to Chicago. 3 h 49 min $207. From Ellicott St & North Division St bus to Buffalo airport, fly to Chicago O'Hare airport, then subway to Chicago. 4 h 17 min $188. From Buffalo train to Buffalo Depew Station Amtrak then train to Chicago Union Station Amtrak. 12 h 4 min $185. From Buffalo, NY bus to Toronto, ON then bus to Chicago, IL. 13 h 55 min $100. From Buffalo, NY bus to Akron, OH then bus to Chicago, IL. 14 h 53 min $106. From Buffalo drive to Chicago. 8 h 53 min $64.