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How to get fromBuffalo Central Terminal to Chicago, ILby bus, plane, train (Amtrak), bus (Greyhound) or car

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There are 7 ways to get from Buffalo Central Terminal to Chicago, IL by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 1 bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from William Street Lewis Street West Op to Ellicott Street MTC Staticbus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)planeBUF - ORD
    5h 46m
    $78–497

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus StationbusGreyhound US0170
    2. Take the bus from Cleveland Bus Station to Chicago Bus StationbusGreyhound US0164
    13h 44m
    $58–132

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union StationtrainLake Shore Limited
    12h 26m
    $82–192

  4. Drive 532.9 mi

    1. Drive from Buffalo Central Terminal to Chicago, ILcar532.9 mi
    9h 1m
    $98–141

  5. Line 1 bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from William Street Lewis Street West Op to Ellicott Street MTC Staticbus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)planeBUF - MDW
    5h 35m
    $103–687

  6. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Buffalo, NY to Rochester, NYbus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)planeROC - ORD
    7h 58m
    $158–602

  7. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo, NY to Rochester, NYbus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)planeROC - MDW
    7h 50m
    $113–642

Buffalo Central Terminal to Chicago, IL by foot and bus

Calendar7Weekly Services
Duration13h 44mAverage Duration
Ticket$58Cheapest Price
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Questions & Answers

What companies run services between Buffalo Central Terminal, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $80–190 and the journey takes 10h 33m. Alternatively, you can take a vehicle from Buffalo Central Terminal to Chicago Bus Station via William Street Lewis Street West Op, Buffalo, and Cleveland Bus Station in around 13h 44m.

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