COVID-19 Travel restrictions may apply upon entering France. Learn More.

There are 9 ways to get from Brussels-South Station to Lyon by train, bus, rideshare, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  3h 48m

  1. Take the train from Brussel-Zuid / Bruxelles-Midi to Lyon Part Dieu Tgv

110€ - 150€

Cheapest option

Bus  •  10h 45m

  1. Take the bus from Brussels South to Lyon Perrache N769

35€ - 45€

7 alternative options

Rideshare  •  8h 55m

  1. Take the rideshare from Brussels to Lyon 707.8 km

45€

Drive  •  6h 41m

  1. Drive from Brussels-South Station to Lyon 706.2 km

75€ - 120€

Fly Brussels to Lyon  •  4h 33m

  1. Fly from Brussels (BRU) to Lyon (LYS) BRU - LYS

53€ - 207€

Train to Lille Lesquin, fly to Lyon  •  4h 39m

  1. Take the train from Brussel-Zuid / Bruxelles-Midi to Lille Europe
  2. Fly from Lille Lesquin (LIL) to Lyon (LYS) LIL - LYS

120€ - 521€

Train to Paris CDG, fly to Lyon  •  4h 25m

  1. Take the train from Brussel-Zuid / Bruxelles-Midi to Aeroport Cdg2 Tgv Roissy
  2. Fly from Paris CDG (CDG) to Lyon (LYS) CDG - LYS

117€ - 236€

Train to Amsterdam Schiphol, fly to Lyon  •  5h 52m

  1. Take the train from Brussel-Zuid / Bruxelles-Midi to Schiphol Airport
  2. Fly from Amsterdam Schiphol (AMS) to Lyon (LYS) AMS - LYS

125€ - 315€

Fly Brussels to Geneva, train  •  6h 59m

  1. Fly from Brussels (BRU) to Geneva (GVA) BRU - GVA
  2. Take the train from Geneve to Lyon Part Dieu

88€ - 191€

Brussels-South Station to Lyon by buses

The bus journey time between Brussels-South Station and Lyon is around 10h 45m and covers a distance of around 798 km. The fastest bus normally takes 10h 45m. Operated by FlixBus, the Brussels-South Station to Lyon bus service departs from Brussels South and arrives in Lyon Perrache. Typically seven buses run weekly, although weekend and holiday schedules can vary so check in advance.

Bus route overview

Average bus time:
10h 45m
Fastest bus time:
10h 45m
Buses per week:
7
Cheapest price:
35€
Carbon emissions:
99 kg CO2

First and last buses

First bus departs at:
20:10
Last bus departs at:
20:10

The schedules shown below are for the next available departures.

Brussels-South Station to Lyon bus schedules

Belgium → France
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International entry into France from Belgium

  • Entry is partially open for citizens and permanent residents of Belgium
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Allowed for: Citizens and permanent residents of France, as well as residents from EU Schengen Area (EU countries, Iceland, Liechtenstein, Norway, and Switzerland), Andorra, Australia, Cyprus, Israel, Japan, Monaco, New Zealand, San Marino, Singapore, South Korea and Vatican

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Conditions of entry into France from Belgium

  • Negative Covid-19 test issued at most 3 days before arrival or 7 day mandatory self-quarantine
  • Health screen upon arrival. Those showing symptoms will be asked to self-quarantine
  • Health declaration required
  • Mandatory installation of smart phone app for contact purposes
This applies to arrivals from all countries, with no exceptions
Show more details
  • Negative Covid-19 test issued at most 3 days before arrival or 7 day mandatory self-quarantine
  • Health screen upon arrival. Those showing symptoms will be asked to self-quarantine
  • Health declaration required
  • Mandatory installation of smart phone app for contact purposes
This applies to arrivals from all countries, with no exceptions
  • 7-day mandatory self-quarantine and COVID-19 test at the end of the isolation period
This applies to arrivals from Australia, Israel, Japan, New Zealand, Singapore, South Korea and United Kingdom
  • Exempted International Movement Certificate for travel required
This doesn't apply to arrivals from: EU Schengen Area, Andorra, Monaco, Vatican, San Marino, Cyprus, Australia, Israel, Japan, New Zealand, Singapore, South Korea and United Kingdom

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Considerations leaving from Belgium

The official advice is to avoid non-essential international travel to high risk countries

Frequently Asked Questions


Yes, but conditions apply when entering France from Belgium.

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Domestic travel is restricted

  • Face masks are mandatory
  • There is a social distancing requirement of 1 metre
  • Nationwide control measures in place

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The national COVID-19 helpline number in Lyon is 800 130 000.

Wearing a face mask on public transport in Lyon is mandatory.

The social distance requirement in Lyon is 1 metre.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800 130 000.

No, but conditions apply when returning to Belgium from France.

See options for return travel.

Last updated: 8 Jun 2021
Exceptions may apply, for full details: European Union.

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This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
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Questions & Answers

The cheapest way to get from Brussels-South Station to Lyon is to bus which costs 35€ - 45€ and takes 10h 45m.

More details

The quickest way to get from Brussels-South Station to Lyon is to train which costs 110€ - 150€ and takes 3h 48m.

More details

Yes, there is a direct bus departing from Brussels South and arriving at Lyon Perrache. Services depart once daily, and operate every day. The journey takes approximately 10h 45m.

More details

Yes, there is a direct train departing from Brussel-Zuid / Bruxelles-Midi and arriving at Lyon Part Dieu. Services depart every four hours, and operate every day. The journey takes approximately 3h 43m.

More details

The distance between Brussels-South Station and Lyon is 567 km. The road distance is 706.2 km.

Get driving directions

The best way to get from Brussels-South Station to Lyon without a car is to train which takes 3h 48m and costs 110€ - 150€.

More details

The train from Brussel-Zuid / Bruxelles-Midi to Lyon Part Dieu takes 3h 43m including transfers and departs every four hours.

More details

Brussels-South Station to Lyon bus services, operated by FlixBus, depart from Brussels South station.

More details

Brussels-South Station to Lyon train services, operated by TGV inOui, depart from Brussel-Zuid / Bruxelles-Midi station.

More details

The best way to get from Brussels-South Station to Lyon is to train which takes 3h 48m and costs 110€ - 150€. Alternatively, you can bus, which costs 35€ - 45€ and takes 10h 45m, you could also fly, which costs 50€ - 210€ and takes 4h 33m.

Mode details

Map of how to get from Brussels-South Station to Lyon.
Launch map view
  • Distance: 566.9 km
  • Duration: 3h 48m

What companies run services between Brussels-South Station, Belgium and Lyon, France?

TGV inOui operates a train from Brussel-Zuid / Bruxelles-Midi to Lyon Part Dieu every 4 hours. Tickets cost 110€ - 150€ and the journey takes 3h 43m. Alternatively, FlixBus operates a bus from Brussels South to Lyon Perrache once daily. Tickets cost 35€ - 45€ and the journey takes 10h 45m.

Airlines
Air France
Website
airfrance.com
Flights from Lille Lesquin to Lyon
Ave. Duration
1h 20m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
110€ - 280€
Flights from Paris CDG to Lyon
Ave. Duration
1h 7m
When
Every day
Estimated price
45€ - 160€
Flights from Amsterdam Schiphol to Lyon
Ave. Duration
1h 36m
When
Every day
Estimated price
100€ - 270€
Flights from Amsterdam Schiphol to Lyon via Paris CDG
Ave. Duration
3h 47m
When
Every day
Estimated price
95€ - 230€
Brussels Airlines
Website
brusselsairlines.com
Flights from Brussels to Lyon
Ave. Duration
1h 25m
When
Every day
Estimated price
45€ - 220€
Flights from Brussels to Geneva
Ave. Duration
1h 18m
When
Every day
Estimated price
60€ - 290€
Lufthansa
Website
lufthansa.com
Flights from Brussels to Lyon via Frankfurt
Ave. Duration
3h 30m
When
Every day
Estimated price
100€ - 240€
Flights from Amsterdam Schiphol to Lyon via Munich
Ave. Duration
3h 35m
When
Monday, Tuesday, Wednesday and Thursday
Estimated price
180€ - 400€
Flights from Amsterdam Schiphol to Lyon via Frankfurt
Ave. Duration
3h 45m
When
Every day
Estimated price
180€ - 400€
Flights from Brussels to Geneva via Frankfurt
Ave. Duration
3h
When
Every day
Estimated price
80€ - 290€
KLM
Website
klm.com
Flights from Amsterdam Schiphol to Lyon
Ave. Duration
1h 36m
When
Every day
Estimated price
100€ - 270€
easyJet
Website
easyjet.com
Flights from Brussels to Geneva
Ave. Duration
1h 17m
When
Every day
Estimated price
40€ - 180€
Alitalia
Website
alitalia.com
Flights from Brussels to Geneva via Milan Linate
Ave. Duration
3h 30m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
140€ - 330€
Train operators
TGV inOui

France’s high-speed TGV train network runs at speeds of up to 320km/h connecting major cities across France and into neighbouring countries. All TGV tickets include a seat reservation; seating is 1+2 in 1st class, 2+2 in 2nd class. Popular routes include Paris to Marseille and Paris to Strasbourg. Most TGVs have a cafe area, power points at each seat and WiFi.

Contact Details
Phone
0033 892 353535
Website
en.oui.sncf
Train from Brussel-Zuid / Bruxelles-Midi to Lyon Part Dieu
Ave. Duration
3h 43m
Frequency
Every 4 hours
Estimated price
110€ - 150€
Website
Oui.SNCF
2nd Class
110€ - 130€
1st Class
120€ - 150€
Train from Brussel-Zuid / Bruxelles-Midi to Lille Europe
Ave. Duration
35 min
Frequency
Every 3 hours
Estimated price
27€ - 40€
Website
Oui.SNCF
2nd Class
32€ - 38€
1st Class
27€ - 32€
Train from Brussel-Zuid / Bruxelles-Midi to Aeroport Cdg2 Tgv Roissy
Ave. Duration
1h 36m
Frequency
Every 2 hours
Estimated price
55€ - 70€
Website
Oui.SNCF
2nd Class
55€ - 70€
1st Class
55€ - 70€
Train from Geneve to Lyon Part Dieu
Ave. Duration
1h 43m
Frequency
Once daily
Estimated price
35€ - 45€
Website
Oui.SNCF
2nd Class
35€ - 45€
1st Class
35€ - 45€
Thalys
Phone
+32 70 66 77 88
Website
thalys.com
Train from Brussel-Zuid / Bruxelles-Midi to Schiphol Airport
Ave. Duration
1h 33m
Frequency
Every 4 hours
Estimated price
60€ - 120€
Website
Thalys
Standard
60€ - 85€
Comfort
70€ - 95€
Premium
85€ - 120€
Swiss Railways (SBB/CFF/FFS)

The national railway company of Switzerland, Swiss Railways operates trains throughout the country and adjacent European nations including Germany, France, Italy and Austria. Tickets are sold in two classes - First and Second - with most long-distance trains offering a bistro car serving beverages and snacks. Individual tickets can be bought easily at stands, while a variety of travel passes are on offer to suit different travel needs.

Contact Details
Phone
+41 51 220 11 11
Website
sbb.ch
Train from Geneve to Lyon Part Dieu
Ave. Duration
1h 52m
Frequency
Every 3 hours
Estimated price
45€ - 90€
Website
Swiss Railways (SBB/CFF/FFS)
Bus operators
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Bus from Brussels South to Lyon Perrache
Ave. Duration
10h 45m
Frequency
Once daily
Estimated price
35€ - 45€
Website
flixbus.co.uk
Other operators
BlaBlaCar

Blablacar is a popular ridesharing platform with 70 million users over 22 (mostly European) countries. The basic idea is that you carpool with locals who are already planning to drive your route and have space in their car. With some flexibility, you’ll get to your destination often faster and cheaper than other means. On the website or app, enter your departure and arrival points and your date of travel, sift through the profiles of drivers who’ve posted pre-planned drives and find one whose timing and preferences match yours. Request to join the ride, wait to be accepted, and pay your share of the set price.

Rome2rio's guide to BlaBlaCar
Contact Details
Website
blablacar.com
Rideshare from Brussels to Lyon
Ave. Duration
8h 31m
Frequency
Twice daily
Estimated price
45€
Book at
blablacar.co.uk

Want to know more about travelling around France

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Brussels Airport to Lyon Airport is the direct flight which takes 1h 25m.

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Brussels-South Station to Lyon bus services, operated by FlixBus, arrive at Lyon Perrache station.

More details

Brussels-South Station to Lyon train services, operated by TGV inOui, arrive at Lyon Part Dieu station.

More details

Yes, the driving distance between Brussels-South Station to Lyon is 706 km. It takes approximately 6h 41m to drive from Brussels-South Station to Lyon.

Get driving directions

Brussels Airlines and Lufthansa offer flights from Brussels Airport to Lyon Airport.

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Book your Brussels-South Station to Lyon bus tickets online with Omio and FlixBus.

Search and book

There are 337+ hotels available in Lyon. Prices start at 75€ per night.

More details

Check out Blablacar's carpooling service for rideshare options between Brussels-South Station and Lyon. A great option if you don't have a driver's licence or want to avoid public transport.

Read Rome2rio's guide to Blablacar