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How to get fromBrookline to BuffaloBy plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 6 ways to get from Brookline to Buffalo by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    4h 1m
    $154–937

  2. Bus via Ithaca

    cheapest
    1. Take the bus from Boston to Ithacabus bus FlixBus 2691
    2. Take the bus from Ithaca to Buffalobus bus FlixBus N2687 / ...
    13h 52m
    $75–187

  3. Bus (Greyhound)

    1. Take the bus from Boston to Buffalobus bus Greyhound US0171
    11h 13m
    $77–154

  4. Train (Amtrak)

    1. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    12h 53m
    $141–360

  5. Drive 450.8 mi

    1. Drive from Brookline to Buffalocar car 450.8 mi
    7h 53m
    $83–119

  6. Fly to Rochester, bus

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 23m
    $266–854

Brookline to Buffalo by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 13mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

What companies run services between Brookline, MA, USA and Buffalo, NY, USA?

American Airlines, JetBlue Airways, and two other airlines fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, Greyhound USA operates a bus from Boston to Buffalo once daily. Tickets cost $75–150 and the journey takes 10h 5m.

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Need to know: Greyhound

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