There is no direct connection from Brindisi to Tirana. However, you can take the bus and ferry to Fier then take the bus to Tiranë. Alternatively, Eurolines IT operates a vehicle from Brindisi to Tirana twice a week. Tickets cost $55 - $80 and the journey takes 16 h 10 min. Florentia Bus also services this route once a week.
How to get from Brindisi to Tirana
From Brindisi bus and ferry to Fier then bus to Tiranë. 6 h 33 min 69€. From Brindisi Autorità Portuale bus and ferry to Tiranë. 16 h 10 min 66€. From Brindisi drive to Brindisi, car ferry to Vlorë, then drive to Tirana. 7 h 1 min.