Plymouth & Brockton operates a bus from Boston to South Yarmouth hourly. Tickets cost $19 - $27 and the journey takes 1 h 40 min.
How to get from Boston to South Yarmouth
From Boston, MA - South Station Transp. Center bus to Hyannis Transportation Center then bus to Main Street, South Yarmouth. 3 h 9 min $29. From Boston drive to South Yarmouth. 1 h 30 min $9. From South Station Silver Line - Outbound bus to Boston airport, fly to Provincetown airport, then taxi to South Yarmouth. 2 h 52 min $403.