From Boston, MA bus to Wells, ME then taxi to Sanford. 1 h 58 min $76. From Boston North Station Amtrak train to Wells Amtrak then taxi to Sanford. 2 h 9 min $92. From Boston, MA - South Station bus to Dover, NH then taxi to Sanford. 2 h 45 min $210. From Boston drive to Sanford. 1 h 44 min $10.
Greyhound USA operates a bus from Boston to Sanford twice daily. Tickets cost $14 - $40 and the journey takes 1 h 37 min. Alternatively, Amtrak operates a train from Boston to Sanford 5 times a day. Tickets cost $28 - $60 and the journey takes 1 h 48 min.