Amtrak Acela Express operates a train from Boston to Guilford hourly. Tickets cost $100 - $270 and the journey takes 2 h 7 min. Shore Line East also services this route hourly. Alternatively, Megabus operates a bus from Boston to Guilford 3 times a day. Tickets cost $10 - $25 and the journey takes 2 h 40 min. 3 other operators also service this route.
From Boston South Station Amtrak train to New Haven Union Station then train to Guilford. 3 h 20 min $212. From Boston, MA Megabus to Union Ave and Union Station, bus to Church St and George St, then line 201 bus to State St and Boston Post Rd. 4 h 15 min $29. From Boston drive to Guilford. 2 h 25 min $16.