Greyhound USA operates a bus from Boston to Great Barrington every 4 hours. Tickets cost $16 - $40 and the journey takes 1 h 55 min. 3 other operators also service this route. Alternatively, Amtrak operates a train from Boston to Great Barrington once daily. Tickets cost $35 - $85 and the journey takes 3 h 49 min. Berkshire Region Transit also services this route every 3 hours.
From Boston, MA bus to Springfield, MA, bus to Lee Premium Outlets, then line 21 bus to Rite Aid. 4 h 48 min $42. From Boston South Station Amtrak train to Intermodal Center then bus to Rite Aid. 5 h 25 min $61. From Boston drive to Great Barrington. 2 h 28 min $16.