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How to get fromBig Pine Key to San Diegoby plane, bus (Greyhound, Flixbus), bus, train, car or shuttle

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There are 7 ways to get from Big Pine Key to San Diego by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Key West International Airport

    best
    1. Fly from Key West International Airport (EYW) to San Diego International Airport (SAN)planeEYW - SAN
    9h 28m
    $251–895

  2. Bus

    1. Take the bus from Big Pine Key to Miami Airport Stationbus
    2. Take the bus from Dolphin Mall - Miami to Houstonbus
    3. Take the bus from Houston to El Pasobus
    4. Take the bus from El Paso to 2474 E Florence Ave - Huntington Parkbus
    5. Take the bus from Huntington Park to San Diegobus
    2d 13h
    $476–867

  3. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus
    2. Take the train from Hollywood Amtrak Station to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
    4. Take the train from Fullerton Amtrak Station to San Diegotrain
    4d 3h
    $457–2,122

  4. Drive 2,753.9 mi

    1. Drive from Big Pine Key to San Diegocar2,753.9 mi
    44h 29m
    $503–726

  5. Shuttle to Miami International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle
    2. Fly from Miami International Airport (MIA) to San Diego International Airport (SAN)planeMIA - SAN
    10h 4m
    $266–590

  6. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to San Diego International Airport (SAN)planeFLL - SAN
    10h 49m
    $274–494

  7. Bus via Atlanta

    1. Take the bus from Big Pine Key to Miami Airport Stationbus
    2. Take the bus from Miami Airport Station to Atlanta Bus Stationbus
    3. Take the bus from Atlanta Bus Station to Dallas Bus Stationbus
    4. Take the bus from Dallas Bus Station to Los Angeles Union Stationbus
    5. Take the bus from Los Angeles Union Station to San Diegobus
    3d
    $287–682

Big Pine Key to San Diego by bus and train

Calendar7Weekly Services
Duration4d 3hAverage Duration
Ticket$457Cheapest Price
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Questions & Answers

What companies run services between Big Pine Key, FL, USA and San Diego, CA, USA?

American Airlines, Delta, and United Airlines fly from Key West International Airport (EYW) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from Big Pine Key to San Diego via Miami Airport Station, Dolphin Mall - Miami, Houston, El Paso, and Huntington Park in around 2d 13h.

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