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How to get fromAvignon to Sienaby train (TGV), bus, car, train, plane or train (TGV, Trenitalia)

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There are 8 ways to get from Avignon to Siena by train (TGV), bus, car, train, plane, or train (TGV, Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Avignon Tgv to Lyon Part DieutrainTgv
    2. Take the train from Lyon Part Dieu to Milano CentraletrainFr
    3. Take the train from Milano Centrale to Florence Santa Maria Novellatrain
    4. Take the train from Firenze S.M.N. to SienatrainRe
    12h 2m
    €103–312
  2. Bus via Genoa

    cheapest
    1. Take the bus from Avignon to Genoabus1922
    2. Take the bus from Genoa to Sienabus516 / ...
    14h 5m
    €44–111
  3. Bus

    1. Take the bus from Avignon to Marseille, Gare de Marseille-Saint-Charlesbus
    2. Take the bus from Marseille - Saint-Charles Bus Station to Florence Villa Constanza Bus Stationbus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus443 / ...
    12h 42m
    €55–115
  4. Drive 713 km

    1. Drive from Avignon to Sienacar713 km
    7h 46m
    €110–159
  5. Train to Marseille Provence Airport, fly to Florence Peretola Airport, train

    1. Take the train from Avignon Tgv to Aix En Provence Tgvtrain
    2. Fly from Marseille Provence Airport (MRS) to Florence Peretola Airport (FLR)planeMRS - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain
    9h 18m
    €105–291
  6. Train via Ventimiglia

    1. Take the train from Avignon Tgv to Nice VilletrainTgv
    2. Take the train from Ventimiglia to Pisa CentraletrainIc
    3. Take the train from Pisa Centrale to EmpolitrainRe
    4. Take the train from Empoli to SienatrainRe
    12h 45m
    €80–144
  7. Train to Nice Côte D'Azur International Airport, fly to Florence Peretola Airport, train

    1. Take the train from Avignon Tgv to Antibestrain
    2. Fly from Nice Côte D'Azur International Airport (NCE) to Florence Peretola Airport (FLR)planeNCE - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain
    9h 55m
    €126–267
  8. Train to Marseille Provence Airport, fly to Venice Marco Polo Airport, train

    1. Take the train from Avignon Tgv to Aix En Provence Tgvtrain
    2. Fly from Marseille Provence Airport (MRS) to Venice Marco Polo Airport (VCE)planeMRS - VCE
    3. Take the train from Venezia Mestre to Firenze S.M.N.train
    4. Take the train from Firenze S.M.N. to Sienatrain
    9h 57m
    €104–289

Avignon to Siena by train

Calendar14Weekly Trains
Duration12h 2mAverage Duration
Ticket€103Cheapest Price
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Questions & Answers

What companies run services between Avignon, France and Siena, Italy?

You can take a train from Avignon Tgv to Siena via Lyon Part Dieu, Milano Centrale, and Firenze S.M.N. in around 12h 2m. Alternatively, you can take a bus from Avignon to Siena via Marseille - Saint-Charles Bus Station and Florence Villa Constanza Bus Station in around 12h 42m.

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