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How to get fromAvignon to Sienaby train, plane, train (TGV), bus, car or train (TGV, Trenitalia)

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There are 8 ways to get from Avignon to Siena by train, plane, train (TGV), bus, car, or train (TGV, Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Lyon–Saint Exupéry Airport, fly, train

    best
    1. Take the train from Avignon Tgv to Lyon-Saint Exupery Tgvtrain
    2. Fly from Lyon–Saint Exupéry Airport (LYS) to Florence Peretola Airport (FLR)planeLYS - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain
    7h 1m
    €84–422

  2. Bus via Genoa

    cheapest
    1. Take the bus from Avignon Le Pontet Bus Station to Genoa Piazza AcquaverdebusUnion Ivkoni - Unibus 3574 / ...
    2. Take the bus from Genoa Piazza della Vittoria to Siena Central Train StationbusItabus
    13h 8m
    €30–57

  3. Train

    1. Take the train from Avignon Tgv to Lyon Part DieutrainTgv
    2. Take the train from Lyon Part Dieu to Milano CentraletrainFr
    3. Take the train from Milano Centrale to Florence Santa Maria Novellatrain
    4. Take the train from Firenze S.M.N. to SienatrainRe
    12h 2m
    €98–308

  4. Bus

    1. Take the bus from Avignon to Marseille, Gare de Marseille-Saint-Charlesbus
    2. Take the bus from Marseille, Gare de Marseille-Saint-Charles to Florence Villa Constanza Bus Stationbus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus443 / ...
    12h 55m
    €46–150

  5. Drive 712.7 km

    1. Drive from Avignon to Sienacar712.7 km
    7h 46m
    €112–161

  6. Train to Marseille Provence Airport, fly, train

    1. Take the train from Avignon Tgv to Aix En Provence Tgvtrain
    2. Fly from Marseille Provence Airport (MRS) to Florence Peretola Airport (FLR)planeMRS - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain
    9h 19m
    €99–309

  7. Train, train to Nice Côte D'Azur International Airport, fly

    1. Take the train from Avignon Tgv to Marseille St Charlestrain
    2. Take the train from Marseille St Charles to Cannestrain
    3. Fly from Nice Côte D'Azur International Airport (NCE) to Florence Peretola Airport (FLR)planeNCE - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain
    10h 32m
    €123–336

  8. Train via Ventimiglia

    1. Take the train from Avignon Tgv to Nice VilletrainTgv
    2. Take the train from Ventimiglia to Pisa CentraletrainIc
    3. Take the train from Pisa Centrale to EmpolitrainRe
    4. Take the train from Empoli to SienatrainRe
    12h 49m
    €82–149

Avignon to Siena by train

Calendar14Weekly Trains
Duration12h 2mAverage Duration
Ticket€98Cheapest Price
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Questions & Answers

What companies run services between Avignon, France and Siena, Italy?

You can take a train from Avignon Tgv to Siena via Lyon Part Dieu, Milano Centrale, and Firenze S.M.N. in around 12h 2m. Alternatively, you can take a bus from Avignon to Siena via Marseille, Gare de Marseille-Saint-Charles and Florence Villa Constanza Bus Station in around 12h 55m.

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