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How to get fromAppleton to Knoxvilleby plane, bus, train, bus (Flixbus, Greyhound), car or bus (Flixbus)

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There are 7 ways to get from Appleton to Knoxville by plane, bus, train, bus (Flixbus, Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Appleton International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS)plane plane ATW - TYS
    4h 21m
    $203–892
  2. Drive 715.2 mi

    cheapest
    1. Drive from Appleton to Knoxvillecar car 715.2 mi
    12h 31m
    $131–189
  3. Bus, train

    1. Take the bus from Appleton Amtrak Station to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    39h 37m
    $413–829
  4. Bus via Detroit

    1. Take the bus from Appleton Transit Center to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 32m
    $349–567
  5. Fly from Green Bay

    1. Fly from Green Bay (GRB) to Mcghee Tyson Airport (TYS)plane plane GRB - TYS
    5h 50m
    $231–912
  6. Bus, train via Ossining

    1. Take the bus from Appleton Amtrak Station to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 14m
    $378–741
  7. Bus

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 7m
    $232–353

Appleton to Knoxville by bus and foot

Calendar3Weekly Services
Duration43h 7mAverage Duration
Ticket$232Cheapest Price
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Questions & Answers

What companies run services between Appleton, WI, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and Delta fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Appleton Transit Center to Knoxville via Detroit Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 32m.

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