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How to get fromAppleton to Knoxvilleby plane, bus, train, bus (Flixbus), car, or taxi

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There are 6 ways to get from Appleton to Knoxville by plane, bus, train, bus (Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Appleton International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS)plane plane ATW - TYS
    4h 7m
    $239–1,037

  2. Drive  715.3 mi

    cheapest
    1. Drive from Appleton to Knoxvillecar car 715.3 mi
    12h 34m
    $131–189

  3. Bus, train via Ossining

    1. Take the bus from Oshkosh to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 2m
    $761–1,135

  4. Bus

    1. Take the bus from Oshkosh to Milwaukeebus bus
    2. Take the bus from Milwaukee Mitchell Airport to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    41h 44m
    $398–579

  5. Taxi to Green Bay, fly

    1. Take the taxi from Appleton to Green Bay (GRB)taxi taxi
    2. Fly from Green Bay (GRB) to Mcghee Tyson Airport (TYS)plane plane GRB - TYS
    5h 3m
    $324–1,187

  6. Bus, train

    1. Take the bus from Oshkosh to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    40h 40m
    $779–1,243

Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS) flights

Calendar65Weekly Planes
Duration5h 17mAverage Duration
Ticket$171Cheapest Price
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Comparing Your Travel Options

Map of how to get from Appleton to Knoxville.ExpandLaunch map view
  • Distance: 648.5 mi
  • Duration: 4h 7m

What companies run services between Appleton, WI, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Prospect and Walnut to Knoxville via Church @ Doty - Neenah Transit Center, Oshkosh, Milwaukee, Milwaukee Mitchell Airport, Chicago Bus Station, New York Midtown, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 44m.

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