There are 7 ways to get from Appleton to Knoxville by plane, bus, train, bus (Flixbus, Greyhound), car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Appleton International Airport
best- Fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS)plane ATW - TYS
4h 21m$203–892Drive 715.2 mi
cheapest- Drive from Appleton to Knoxvillecar 715.2 mi
12h 31m$131–189Bus, train
- Take the bus from Appleton Amtrak Station to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the bus from New York to Knoxvillebus Nyc
39h 37m$413–829Bus via Detroit
- Take the bus from Appleton Transit Center to Detroit Bus Stationbus
- Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus
- Take the bus from New York to Knoxvillebus Nyc
41h 32m$349–567Fly from Green Bay
- Fly from Green Bay (GRB) to Mcghee Tyson Airport (TYS)plane GRB - TYS
5h 50m$231–912Bus, train via Ossining
- Take the bus from Appleton Amtrak Station to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain
- Take the train from Croton-Harmon to 125th Street - Harlemtrain
- Take the bus from New York, NY to Knoxville, TNbus Ny
40h 14m$378–741Bus
- Take the bus from Appleton Transit Center to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to New York City Chinatownbus
- Take the bus from New York, NY to Knoxville, TNbus Ny
43h 7m$232–353
Appleton to Knoxville by bus and foot
Questions & Answers
The cheapest way to get from Appleton to Knoxville is to drive which costs $130 - $190 and takes 12h 31m.
The fastest way to get from Appleton to Knoxville is to fly which takes 4h 21m and costs $200 - $900.
No, there is no direct bus from Appleton to Knoxville station. However, there are services departing from Appleton Transit Center and arriving at Knoxville Station Hall of Fame via Chicago Bus Station, New York, NY, Walmart and Fountain City Superstop. The journey, including transfers, takes approximately 43h 7m.
The distance between Appleton and Knoxville is 652 miles. The road distance is 719.4 miles.
The best way to get from Appleton to Knoxville without a car is to bus and train which takes 39h 37m and costs $410 - $850.
It takes approximately 4h 21m to get from Appleton to Knoxville, including transfers.
Appleton to Knoxville bus services, operated by Flixbus USA, depart from Appleton Transit Center station.
The best way to get from Appleton to Knoxville is to fly which takes 4h 21m and costs $200 - $900. Alternatively, you can bus via Detroit, which costs $340 - $600 and takes 41h 32m.
Appleton to Knoxville bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Knoxville is 1h ahead of Appleton. It is currently 7:51 PM in Appleton and 8:51 PM in Knoxville.
What companies run services between Appleton, WI, USA and Knoxville, TN, USA?
United Airlines, American Airlines, and Delta fly from Appleton International Airport (ATW) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Appleton Transit Center to Knoxville via Detroit Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 32m.
- Website
- delta.com
Flights from Appleton International Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 6h 25m
- When
- Every day
- Estimated price
- $150–850
Flights from Appleton International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $170–900
Flights from Appleton International Airport to Mcghee Tyson Airport via Minneapolis
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $180–950
Flights from Green Bay to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $170–900
Flights from Green Bay to Mcghee Tyson Airport via Minneapolis
- Ave. Duration
- 5h 54m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $180–950
Flights from Green Bay to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 8h 42m
- When
- Every day
- Estimated price
- $150–850
- Website
- united.com
Flights from Appleton International Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $130–800
Flights from Green Bay to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $140–800
- Website
- aa.com
Flights from Appleton International Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 5h 2m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–800
Flights from Appleton International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 7h 24m
- When
- Every day
- Estimated price
- $170–900
Flights from Green Bay to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $140–800
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $18–45
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 20h 12m
- Frequency
- Once daily
- Estimated price
- $200–480
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Croton-Harmon Amtrak Station
- Ave. Duration
- 19h 23m
- Frequency
- Once daily
- Estimated price
- $200–460
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 877.690.5114
- Website
- mta.info
Train from Croton-Harmon to 125th Street - Harlem
- Ave. Duration
- 1h 1m
- Frequency
- Every 20 minutes
- Estimated price
- $10–17
- Website
- https://www.mta.info/agency/metro-north-railroad
- Schedules at
- https://www.mta.info/schedules
- Off-Peak
- $10–12
- Peak
- $14–17
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 23m
- Frequency
- Twice daily
- Estimated price
- $29–55
- Website
- https://www.amtrak.com/home.html
- Phone
- 920 496 3600
- Website
- golamers.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $23–26
- Schedules at
- golamers.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a week
- Estimated price
- $12–21
- Schedules at
- flixbus.com
Bus from Appleton Transit Center to Detroit Bus Station
- Ave. Duration
- 10h 10m
- Frequency
- 4 times a week
- Estimated price
- $55–95
- Schedules at
- flixbus.com
Bus from Appleton Transit Center to Chicago Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 5 times a week
- Estimated price
- $22–40
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to New York City Chinatown
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- $110–200
- Schedules at
- flixbus.com
- Phone
- +1 646-630-7186
- help@wandacoach.com
- Website
- wandacoach.com
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- 3 times a week
- Estimated price
- $95–140
- Website
- https://www.wandacoach.com
- Book at
- https://www.gotobus.com/wanda-travel/
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Detroit Bus Station to Port Authority Bus Terminal
- Ave. Duration
- 16h 45m
- Frequency
- Once daily
- Estimated price
- $110–220
- Website
- https://www.greyhound.com/
- Phone
- +1 615-939-8887
- tennesseetravel@gotobus.com
- Website
- nytnbus.com
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- 3 times a week
- Estimated price
- $95–110
- Schedules at
- nytnbus.com
- Adult One-way
- $95–110
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More Questions & Answers
Yes, the driving distance between Appleton to Knoxville is 719 miles. It takes approximately 12h 31m to drive from Appleton to Knoxville.
There are 292+ hotels available in Knoxville.











