Rome2Rio

How to get fromAppleton to Key Westby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Key West

See all options

There are 6 ways to get from Appleton to Key West by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Appleton International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Key West International Airport (EYW)plane plane ATW - EYW
    5h 57m
    $119–475

  2. Bus

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    43h 1m
    $233–537

  3. Bus, train

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 11h
    $617–1,411

  4. Drive 1,657.8 mi

    1. Drive from Appleton to Key Westcar car 1,657.8 mi
    30h 31m
    $303–437

  5. Fly from Green Bay

    1. Fly from Green Bay (GRB) to Key West International Airport (EYW)plane plane GRB - EYW
    7h 35m
    $142–495

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Appleton to Milwaukee Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Key West International Airport (EYW)plane plane MKE - EYW
    9h 35m
    $166–738

Appleton to Key West by bus and foot

Calendar5Weekly Services
Duration43h 1mAverage Duration
Ticket$233Cheapest Price
See schedules

Questions & Answers

What companies run services between Appleton, WI, USA and Key West, FL, USA?

Delta, United Airlines, and American Airlines fly from Appleton International Airport (ATW) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a bus from Appleton Transit Center to N Roosevelt & 3rd Street via Chicago Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 43h 1m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Appleton

Trips to Key West

Popular routes