There are 6 ways to get from Appleton to Iowa by plane, bus (Flixbus, Greyhound), car, bus, train, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Des Moines
best- Fly from Appleton International Airport (ATW) to Des Moines (DSM)plane ATW - DSM
3h 56m$145–793Fly to Quad City International Airport
cheapest- Fly from Appleton International Airport (ATW) to Quad City International Airport (MLI)plane ATW - MLI
5h 3m$60–314Bus
- Take the bus from Appleton Transit Center to Chicago Bus Stationbus FlixBus 2550
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0155S
14h$92–162Drive 378.6 mi
- Drive from Appleton to Des Moinescar 378.6 mi
7h 5m$70–100Bus, train
- Take the bus from Appleton Amtrak Station to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
14h 31m$103–226Bus via Saint Paul
- Take the bus from Appleton to Wausau Transit Centerbus
- Take the bus from Wausau Amtrak Bus Stop to St. Paul-Minneapolisbus
- Take the bus from MSP Airport to Des Moinesbus
14h 51m$116–250
Appleton International Airport (ATW) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Appleton to Iowa is to drive which costs $65 - $100 and takes 7h 5m.
The fastest way to get from Appleton to Iowa is to fly which takes 3h 56m and costs $140 - $800.
The distance between Appleton and Iowa is 334 miles. The road distance is 380.8 miles.
The best way to get from Appleton to Iowa without a car is to bus which takes 14h and costs $90 - $170.
It takes approximately 3h 56m to get from Appleton to Iowa, including transfers.
The best way to get from Appleton to Iowa is to fly which takes 3h 56m and costs $140 - $800. Alternatively, you can bus, which costs $90 - $170 and takes 14h.
Yes, the driving distance between Appleton to Iowa is 381 miles. It takes approximately 7h 5m to drive from Appleton to Iowa.
There are 248+ hotels available in Iowa.
What companies run services between Appleton, WI, USA and Iowa, USA?
Delta, United Airlines, and two other airlines fly from Appleton International Airport (ATW) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Appleton Transit Center to Des Moines via Chicago Bus Station and Des Moines in around 14h.
- Website
- united.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $110–750
Flights from Appleton International Airport to Des Moines via Denver
- Ave. Duration
- 7h 35m
- When
- Every day
- Estimated price
- $250–1,200
Flights from Appleton International Airport to Quad City International Airport via Chicago O'Hare
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $40–290
- Website
- aa.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 26m
- When
- Every day
- Estimated price
- $110–750
Flights from Appleton International Airport to Quad City International Airport via Chicago O'Hare
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $40–290
Flights from Appleton International Airport to Quad City International Airport via Charlotte
- Ave. Duration
- 6h 11m
- When
- Every day
- Estimated price
- $110–550
- Website
- delta.com
Flights from Appleton International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $110–750
Flights from Appleton International Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $250–1,200
Flights from Appleton International Airport to Des Moines via Detroit
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $160–900
- Website
- allegiantair.com
Flights from Appleton International Airport to Des Moines via Nashville
- Ave. Duration
- 4h 26m
- When
- Monday
- Estimated price
- $200–1,100
Flights from Appleton International Airport to Quad City International Airport via Sarasota/Bradenton
- Ave. Duration
- 7h 23m
- When
- Monday and Friday
- Estimated price
- $160–750
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–50
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Appleton Transit Center to Chicago Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 5 times a week
- Estimated price
- $23–45
- Schedules at
- flixbus.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a week
- Estimated price
- $12–22
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 8h 25m
- Frequency
- Once daily
- Estimated price
- $60–110
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 23m
- Frequency
- Twice daily
- Estimated price
- $30–55
- Website
- https://www.amtrak.com/home.html
Bus from Wausau Amtrak Bus Stop to St. Paul-Minneapolis
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $60–100
- Website
- https://www.amtrak.com/home.html
- Phone
- 920 496 3600
- Website
- golamers.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $23–26
- Schedules at
- golamers.com
Bus from Appleton to Wausau Transit Center
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $23–26
- Schedules at
- golamers.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from MSP Airport to Des Moines
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide












