There are 6 ways to get from Appleton to Florida Keys by plane, bus (Flixbus, Greyhound), bus, train, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Appleton International Airport to Key West International Airport
best- Fly from Appleton International Airport (ATW) to Key West International Airport (EYW)plane ATW - EYW
8h 54m$235–766Bus
cheapest- Take the bus from Appleton Transit Center to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
40h 30m$179–405Bus, train
- Take the bus from Appleton Transit Center to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
2d 10h$278–554Drive 1,642.4 mi
- Drive from Appleton to Florida Keyscar 1,642.4 mi
30h 7m$300–433Fly Green Bay to Key West International Airport
- Fly from Green Bay (GRB) to Key West International Airport (EYW)plane GRB - EYW
10h 23m$253–786Fly Appleton International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Appleton International Airport (ATW) to Fort Lauderdale–Hollywood International Airport (FLL)plane ATW - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
9h 35m$265–586
Appleton International Airport (ATW) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Appleton to Florida Keys is to bus which costs $170 - $410 and takes 40h 30m.
The fastest way to get from Appleton to Florida Keys is to fly which takes 8h 54m and costs $230 - $800.
No, there is no direct bus from Appleton to Florida Keys. However, there are services departing from Appleton Transit Center and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Chicago Bus Station, Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 40h 30m.
The distance between Appleton and Florida Keys is 1448 miles. The road distance is 1652 miles.
The best way to get from Appleton to Florida Keys without a car is to bus which takes 40h 30m and costs $170 - $410.
It takes approximately 8h 54m to get from Appleton to Florida Keys, including transfers.
Appleton to Florida Keys bus services, operated by Flixbus USA, depart from Appleton Transit Center station.
The best way to get from Appleton to Florida Keys is to fly which takes 8h 54m and costs $230 - $800. Alternatively, you can bus, which costs $170 - $410 and takes 40h 30m.
Appleton to Florida Keys bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Yes, the driving distance between Appleton to Florida Keys is 1652 miles. It takes approximately 30h 7m to drive from Appleton to Florida Keys.
What companies run services between Appleton, WI, USA and Florida Keys, FL, USA?
American Airlines, United Airlines, and three other airlines fly from Appleton International Airport (ATW) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Appleton Transit Center to Florida Keys via Chicago Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 40h 30m.
- Website
- aa.com
Flights from Appleton International Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 47m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 6h 26m
- When
- Every day
- Estimated price
- $140–700
Flights from Green Bay to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 42m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $75–360
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport via Chicago O'Hare
- Ave. Duration
- 6h 49m
- When
- Every day
- Estimated price
- $75–360
- Website
- united.com
Flights from Appleton International Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 7h 2m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 35m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport via Chicago O'Hare
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $75–360
- Website
- delta.com
Flights from Appleton International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 7h 23m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Atlanta
- Ave. Duration
- 7h 36m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $75–360
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport via Detroit
- Ave. Duration
- 7h 17m
- When
- Every day
- Estimated price
- $75–370
- Website
- allegiantair.com
Flights from Appleton International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 27m
- When
- Thursday, Saturday, and Sunday
- Estimated price
- $75–360
- Website
- spirit.com
Flights from Appleton International Airport to Key West International Airport via Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 6h 30m
- When
- Thursday and Sunday
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Miami Amtrak Station
- Ave. Duration
- 46h 29m
- Frequency
- Once daily
- Estimated price
- $200–450
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Appleton Transit Center to Chicago Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 5 times a week
- Estimated price
- $30–45
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- 3 times a day
- Estimated price
- $75–150
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 13h 30m
- Frequency
- Once daily
- Estimated price
- $50–180
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 16h 25m
- Frequency
- 4 times a day
- Estimated price
- $75–140
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $65–120
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $21–29
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- https://www.keysshuttle.com
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There are 943+ hotels available in Florida Keys.







