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How to get fromAppleton to Florenceby plane, bus (Flixbus, Greyhound), bus, train, car or bus (Flixbus)

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There are 7 ways to get from Appleton to Florence by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Appleton International Airport (ATW) to Florence Regional Airport (FLO)plane plane ATW - FLO
    7h 35m
    $103–445

  2. Bus

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    28h
    $176–394

  3. Bus, train

    1. Take the bus from Appleton Amtrak Station to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Selma Stationtrain train
    5. Take the train from Selma Station to Florence Stationtrain train
    34h 51m
    $381–911

  4. Drive 1,020 mi

    1. Drive from Appleton to Florencecar car 1,020 mi
    19h 10m
    $187–269

  5. Fly to Myrtle Beach, bus

    1. Fly from Appleton International Airport (ATW) to Myrtle Beach (MYR)plane plane ATW - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    7h 44m
    $116–450

  6. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Appleton International Airport (ATW) to Charlotte Douglas International Airport (CLT)plane plane ATW - CLT
    2. Take the bus from Charlotte Bus Station to Florence Bus Stationbus bus
    6h 40m
    $105–452

  7. Bus via Hurricane

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Mound St to Hurricanebus bus
    4. Take the bus from Hurricane to Charlotte Bus Stationbus bus
    5. Take the bus from Charlotte Bus Station to Florence Bus Stationbus bus
    28h 20m
    $112–278

Appleton to Florence by bus

Calendar5Weekly Buses
Duration28hAverage Duration
Ticket$176Cheapest Price
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Questions & Answers

What companies run services between Appleton, WI, USA and Florence, SC, USA?

American Airlines flies from Appleton International Airport (ATW) to Florence Regional Airport (FLO) 3 times a day. Alternatively, you can take a bus from Appleton Transit Center to Florence Bus Station via Chicago Bus Station and Atlanta Bus Station in around 28h.

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