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How to get fromAppleton to Des Moinesby plane, bus (Flixbus, Greyhound), car, bus, or train

Find Transport to Des Moines

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There are 6 ways to get from Appleton to Des Moines by plane, bus (Flixbus, Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Appleton International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Des Moines (DSM)plane plane ATW - DSM
    3h 58m
    $87–390

  2. Drive  378.7 mi

    cheapest
    1. Drive from Appleton to Des Moinescar car 378.7 mi
    7h 7m
    $70–100

  3. Bus

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus FlixBus 2550
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    12h
    $79–128

  4. Fly from Green Bay

    1. Fly from Green Bay (GRB) to Des Moines (DSM)plane plane GRB - DSM
    5h 20m
    $114–415

  5. Bus via Rochester

    1. Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus bus
    2. Take the bus from La Crosse to Rochesterbus bus
    3. Take the bus from Rochester to Owatonnabus bus
    4. Take the bus from Owatonna to Des Moinesbus bus
    14h 9m
    $118–194

  6. Bus, train

    1. Take the bus from Appleton to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    14h 35m
    $107–223

Appleton to Des Moines by bus

Calendar5Weekly Buses
Duration12hAverage Duration
Ticket$79Cheapest Price
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Comparing Your Travel Options

Map of how to get from Appleton to Des Moines.ExpandLaunch map view
  • Distance: 332.4 mi
  • Duration: 3h 58m

What companies run services between Appleton, WI, USA and Des Moines, IA, USA?

Delta, United Airlines, and American Airlines fly from Appleton International Airport (ATW) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Appleton Transit Center to Des Moines via Chicago Bus Station in around 12h.

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