There are 6 ways to get from Appleton to Des Moines by plane, bus (Flixbus, Greyhound), car, bus, train, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Appleton International Airport
best- Fly from Appleton International Airport (ATW) to Des Moines (DSM)plane ATW - DSM
3h 49m$85–373Drive 378.6 mi
cheapest- Drive from Appleton to Des Moinescar 378.6 mi
7h 5m$70–100Bus
- Take the bus from Appleton Transit Center to Chicago Bus Stationbus FlixBus 2550
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123 / ...
12h 4m$71–122Fly from Green Bay
- Fly from Green Bay (GRB) to Des Moines (DSM)plane GRB - DSM
5h 39m$108–393Bus, train
- Take the bus from Appleton Amtrak Station to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
12h 35m$76–203Bus via Saint Paul
- Take the bus from Appleton to Wausau Transit Centerbus
- Take the bus from Wausau Amtrak Bus Stop to St. Paul-Minneapolisbus
- Take the bus from MSP Airport to Des Moinesbus
14h 45m
Appleton to Des Moines by bus
Questions & Answers
The cheapest way to get from Appleton to Des Moines is to drive which costs $65 - $100 and takes 7h 5m.
The fastest way to get from Appleton to Des Moines is to fly which takes 3h 49m and costs $85 - $380.
No, there is no direct bus from Appleton to Des Moines. However, there are services departing from Appleton Transit Center and arriving at Des Moines via Chicago Bus Station. The journey, including transfers, takes approximately 12h 4m.
The distance between Appleton and Des Moines is 334 miles. The road distance is 380.8 miles.
The best way to get from Appleton to Des Moines without a car is to bus which takes 12h 4m and costs $70 - $130.
It takes approximately 3h 49m to get from Appleton to Des Moines, including transfers.
Appleton to Des Moines bus services, operated by Flixbus USA, depart from Appleton Transit Center station.
The best way to get from Appleton to Des Moines is to fly which takes 3h 49m and costs $85 - $380. Alternatively, you can bus, which costs $70 - $130 and takes 12h 4m.
Appleton to Des Moines bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Yes, the driving distance between Appleton to Des Moines is 381 miles. It takes approximately 7h 5m to drive from Appleton to Des Moines.
What companies run services between Appleton, WI, USA and Des Moines, IA, USA?
Delta, American Airlines, and United Airlines fly from Appleton International Airport (ATW) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Appleton Transit Center to Des Moines via Chicago Bus Station in around 12h 4m.
- Website
- delta.com
Flights from Appleton International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $50–330
Flights from Appleton International Airport to Des Moines via Detroit
- Ave. Duration
- 5h 35m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $75–390
Flights from Green Bay to Des Moines via Minneapolis
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $55–340
Flights from Green Bay to Des Moines via Detroit
- Ave. Duration
- 5h 44m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $70–390
Flights from Green Bay to Des Moines via Atlanta
- Ave. Duration
- 5h 49m
- When
- Every day
- Estimated price
- $110–550
- Website
- aa.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 14m
- When
- Every day
- Estimated price
- $50–330
Flights from Appleton International Airport to Des Moines via Charlotte
- Ave. Duration
- 7h 7m
- When
- Tuesday and Wednesday
- Estimated price
- $110–550
Flights from Green Bay to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $55–330
- Website
- united.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $50–330
Flights from Green Bay to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $55–330
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Appleton Transit Center to Chicago Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 5 times a week
- Estimated price
- $30–45
- Schedules at
- flixbus.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a week
- Estimated price
- $14–85
- Schedules at
- flixbus.com
- Adult
- $14–85
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 34m
- Frequency
- 3 times a day
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 23m
- Frequency
- Twice daily
- Website
- https://www.amtrak.com/home.html
Bus from Wausau Amtrak Bus Stop to St. Paul-Minneapolis
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- 920 496 3600
- Website
- golamers.com
Bus from Appleton Amtrak Station to Milwaukee
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $23–26
- Schedules at
- golamers.com
Bus from Appleton to Wausau Transit Center
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $23–26
- Schedules at
- golamers.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from MSP Airport to Des Moines
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Book your Appleton to Des Moines bus tickets online with Omio and FlixBus.
There are 252+ hotels available in Des Moines.












