There are 7 ways to get from Antofagasta to Cusco by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  7 h 28 min

  1. Fly from Antofagasta (ANF) to Cuzco (CUZ) ANF - CUZ

$331 - $997

Cheapest option

Bus via Arequipa  •  25 h 49 min

  1. Take the bus from Antofagasta to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Arequipa
  4. Take the bus from Arequipa to Cusco

$48 - $121

5 alternative options

Bus  •  25 h 45 min

  1. Take the bus from Antofagasta to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Puno
  4. Take the bus from Puno to Cusco

Bus via Arequipa #2  •  30 h 4 min

  1. Take the bus from Antofagasta to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Arequipa
  4. Take the bus from Arequipa to Cusco

$100 - $202

Bus, train  •  30 h 5 min

  1. Take the bus from Antofagasta to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Puno
  4. Take the train from Puno to Cusco - Wanchaq

Bus via Arequipa #3  •  36 h 16 min

  1. Take the bus from Antofagasta to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Arequipa
  4. Take the bus from Arequipa to Chivay
  5. Take the bus from Chivay to Cusco

$104 - $137

Drive  •  21 h 50 min

  1. Drive from Antofagasta to Cusco 962 miles

$150 - $230

Questions & Answers

The cheapest way to get from Antofagasta to Cusco is to bus which costs $45 - $130 and takes 25 h 49 min.

More details

The quickest way to get from Antofagasta to Cusco is to fly which costs $330 - $1,000 and takes 7 h 28 min.

More details

The distance between Antofagasta and Cusco is 1138 km. The road distance is 1539.1 km.

Get driving directions

It takes approximately 7 h 28 min to get from Antofagasta to Cusco, including transfers.

More details

No, there is no direct bus from Antofagasta to Cusco. However, there are services departing from Antofagasta and arriving at Cusco via Arica, Tacna and Puno. The journey, including transfers, takes approximately 25 h 45 min.

More details

What companies run services between Antofagasta, Chile and Cusco, Peru?

LATAM Chile and Sky Airline fly from Antofagasta to Cusco every 4 hours. Alternatively, you can take a bus from Antofagasta to Cusco via Arica, Tacna, and Puno in around 25 h 45 min.

Airlines
LATAM Chile
Website
latam.com
Flights from Antofagasta to Cuzco via Lima
Ave. Duration
5 h 3 min
When
Monday, Thursday and Saturday
Estimated price
$400 - $1,100
Flights from Antofagasta to Cuzco via Santiago
Ave. Duration
7 h 26 min
When
Tuesday, Wednesday and Saturday
Estimated price
$400 - $1,100
Flights from Antofagasta to Cuzco via Santiago, Lima
Ave. Duration
9 h 54 min
When
Wednesday, Thursday, Friday and Saturday
Estimated price
$400 - $1,100
Flights from Antofagasta to Cuzco via Concepcion, Santiago
Ave. Duration
9 h 40 min
When
Wednesday
Estimated price
$400 - $1,100
Train operators
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Puno to Cusco - Wanchaq
Ave. Duration
10 h 20 min
Frequency
3 times a week
Estimated price
$200 - $3,100
Schedules at
perurail.com
Book at
pax1.perurail.com
VIP
$210 - $3,100
Regular
$330 - $460
Bus operators
Pullman Bus
Phone
600 320 3200
Website
pullman.cl
Bus from Antofagasta to Arica
Ave. Duration
8 h 30 min
Frequency
Every 4 hours
Estimated price
$20 - $35
Schedules at
pullman.cl
bus
Bus from Arica to Tacna
Ave. Duration
1 h
Frequency
Every 30 minutes
Estimated price
$4
Inka Express
Phone
0051 084 247887
Email
reservascusco@inkaexpress.com
Website
inkaexpress.com.pe
Bus from Puno to Cusco
Ave. Duration
6 h
Frequency
Once daily
Estimated price
$50
Schedules at
inkaexpress.com.pe
Oltursa
Website
oltursa.pe
Bus from Tacna to Arequipa
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$10 - $26
Schedules at
oltursa.pe
Bus from Arequipa to Cusco
Ave. Duration
10 h 15 min
Frequency
Twice daily
Estimated price
$15 - $35
Schedules at
oltursa.pe
Transportes Reyna
Phone
+51 54 429339
Email
transreyna@reyna.com.pe
Website
reyna.com.pe
Bus from Arequipa to Cusco
Ave. Duration
8 h 30 min
Frequency
Twice daily
Estimated price
$19
Schedules at
reyna.com.pe
Bus from Arequipa to Chivay
Ave. Duration
4 h 26 min
Frequency
Every 4 hours
Estimated price
$6
Schedules at
reyna.com.pe
Movil Tours
Phone
716-8000
Email
info@moviltours.com.pe
Website
moviltours.com.pe
Bus from Arequipa to Cusco
Ave. Duration
10 h
Frequency
Once daily
Estimated price
$18 - $60
Schedules at
moviltours.com.pe
Economy
$22 - $35
Regular
$28 - $40
Suite
$40 - $60
Transzela
Turbus
Website
turbus.cl
Bus from Antofagasta to Arica
Ave. Duration
9 h 30 min
Frequency
4 times a day
Estimated price
$17 - $55
Schedules at
turbus.cl
2nd Class
$17 - $35
Premium
$35 - $55
1st Class
$40 - $65
Peru Hop
Phone
+51 1 2422140
Email
info@peruhop.com
Bus from Arequipa to Cusco
Ave. Duration
11 h 45 min
Frequency
5 times a week
Estimated price
$70 - $120
Schedules at
peruhop.com
Book at
peruhop.com
Fichtur VIP
Phone
+56 (02) 7205232
Website
fichtur.cl
Bus from Antofagasta to Arica
Ave. Duration
12 h 10 min
Frequency
Twice daily
Estimated price
$20
Schedules at
viajaenbus.cl
Buses Norte Grande
Phone
+56993068508
Website
busesnortegrande.cl
Bus from Antofagasta to Arica
Ave. Duration
7 h 30 min
Frequency
6 times a week
Schedules at
busesnortegrande.cl
Pullman Carmelita
Phone
+56 (57) 248 3147
Bus from Antofagasta to Arica
Ave. Duration
10 h 58 min
Frequency
Once daily
Estimated price
$29 - $40
Schedules at
voyhoy.com
4M
Phone
+51 54 452296
Email
informes@4m-expresss.com
Website
busperu4m.com
Bus from Chivay to Cusco
Ave. Duration
9 h 45 min
Frequency
3 times a week
Estimated price
$65
Schedules at
busperu4m.com

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