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There are 7 ways to get from St. Louis to Great Smoky Mountains by plane, car, bus, night bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  6h 49m

  1. Fly from St. Louis (STL) to Knoxville (TYS) STL - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$208 - $1,112

Cheapest option

Bus, drive via Columbus, Oh  •  25h 38m

  1. Take the bus from St Louis, Mo to Columbus, Oh
  2. Take the bus from Columbus, Oh to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$111 - $278

5 alternative options

Fly to Asheville, drive  •  7h 20m

  1. Fly from St. Louis (STL) to Asheville (AVL) STL - AVL
  2. Drive from Asheville to Great Smoky Mountains

$220 - $1,114

Fly to Greenville/Spartanburg, drive  •  8h 12m

  1. Fly from St. Louis (STL) to Greenville/Spartanburg (GSP) STL - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains

$176 - $432

Bus, drive  •  27h 18m

  1. Take the bus from St Louis, Mo to Atlanta, Ga
  2. Take the bus from Atlanta, Ga to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$119 - $285

Night bus, train, bus, drive  •  27h 46m

  1. Take the night bus from St Louis, Mo to Atlanta, Ga
  2. Take the train from Atlanta Peachtree Station to High Point Amtrak Station
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$147 - $358

Drive  •  9h 43m

  1. Drive from St. Louis to Great Smoky Mountains 552.4 miles

$50 - $80

Questions & Answers

The cheapest way to get from St. Louis to Great Smoky Mountains is to drive which costs $50 - $80 and takes 9h 43m.

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The quickest way to get from St. Louis to Great Smoky Mountains is to fly and drive which costs $200 - $1,200 and takes 6h 49m.

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The distance between St. Louis and Great Smoky Mountains is 427 miles. The road distance is 552.4 miles.

Get driving directions

It takes approximately 6h 49m to get from St. Louis to Great Smoky Mountains, including transfers.

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There is no direct flight from St. Louis Airport to Knoxville Airport. The quickest flight takes 3h 20m and has one stopover.

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Great Smoky Mountains is 1h ahead of St. Louis. It is currently 6:09 AM in St. Louis and 7:09 AM in Great Smoky Mountains.

Yes, the driving distance between St. Louis to Great Smoky Mountains is 552 miles. It takes approximately 9h 43m to drive from St. Louis to Great Smoky Mountains.

Get driving directions

United Airlines, American Airlines and Delta offer flights from St. Louis Airport to Knoxville Airport.

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There are 1411+ hotels available in Great Smoky Mountains. Prices start at $130 USD per night.

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The best way to get from St. Louis to St. Louis Airport is to train which takes 31m and costs $3.

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Map of how to get from St. Louis to Great Smoky Mountains.
Launch map view
  • Distance: 426.7 miles
  • Duration: 6h 49m

What companies run services between St. Louis, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from St. Louis to Great Smoky Mountains. However, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from St. Louis to Knoxville via Atlanta
Ave. Duration
4h 3m
When
Every day
Estimated price
$200 - $1,100
Flights from St. Louis to Knoxville via Detroit
Ave. Duration
4h 31m
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Minneapolis
Ave. Duration
5h 13m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Atlanta
Ave. Duration
4h 28m
When
Every day
Estimated price
$210 - $1,100
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
3h 53m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $460
Flights from St. Louis to Greenville/Spartanburg via Detroit
Ave. Duration
5h 2m
When
Every day
Estimated price
$300 - $460
American Airlines
Website
aa.com
Flights from St. Louis to Knoxville via Charlotte
Ave. Duration
4h 13m
When
Every day
Estimated price
$230 - $1,100
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
3h 57m
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Dallas/Ft.Worth
Ave. Duration
4h 55m
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Asheville via Charlotte
Ave. Duration
4h 41m
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via New York La Guardia
Ave. Duration
7h 2m
When
Saturday and Sunday
Estimated price
$300 - $1,300
Flights from St. Louis to Greenville/Spartanburg via Charlotte
Ave. Duration
4h 32m
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4h 57m
When
Saturday and Sunday
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5h 17m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Philadelphia
Ave. Duration
5h 22m
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Dallas/Ft.Worth
Ave. Duration
5h 36m
When
Tuesday and Wednesday
Estimated price
$290 - $450
United Airlines
Website
united.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4h 9m
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Knoxville via Washington Dulles
Ave. Duration
4h 57m
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Asheville via Chicago O'Hare
Ave. Duration
5h 27m
When
Every day
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Washington Dulles
Ave. Duration
4h 47m
When
Every day
Estimated price
$270 - $1,300
Flights from St. Louis to Asheville via Newark
Ave. Duration
5h 53m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $1,300
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4h 28m
When
Every day
Estimated price
$320 - $490
Flights from St. Louis to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4h 47m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $490
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
5h 8m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $900
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Atlanta Peachtree Station to High Point Amtrak Station
Ave. Duration
7h 12m
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$250 - $350
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Columbus, Oh
Ave. Duration
8h 5m
Frequency
5 times a day
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Columbus, Oh to Winston Salem, Nc
Ave. Duration
10h 35m
Frequency
3 times a day
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2h 55m
Frequency
Once daily
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from St Louis, Mo to Atlanta, Ga
Ave. Duration
13h 40m
Frequency
Once daily
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Atlanta, Ga to Winston Salem, Nc
Ave. Duration
6h 40m
Frequency
3 times a day
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85

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