There are 6 ways to get from St. Louis to Great Smoky Mountains by plane, car, bus or night bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  7 h 14 min

  1. Fly from St. Louis (STL) to Knoxville (TYS) STL - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$208 - $1,112

Cheapest option

Bus, Megabus, drive  •  14 h 27 min

  1. Take the bus from St Louis, Mo to Nashville, Tn
  2. Take the bus from Nashville, TN to Chattanooga
  3. Take the Megabus from Chattanooga to Knoxville
  4. Drive from Knoxville to Great Smoky Mountains

$67 - $142

4 alternative options

Fly to Asheville, drive  •  7 h 20 min

  1. Fly from St. Louis (STL) to Asheville (AVL) STL - AVL
  2. Drive from Asheville to Great Smoky Mountains

$220 - $1,114

Fly to Greenville/Spartanburg, drive  •  8 h 17 min

  1. Fly from St. Louis (STL) to Greenville/Spartanburg (GSP) STL - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains

$175 - $432

Night bus, bus, Megabus, drive  •  14 h 40 min

  1. Take the night bus from St Louis, Mo to Nashville, Tn
  2. Take the bus from Nashville, TN to Chattanooga
  3. Take the Megabus from Chattanooga to Knoxville
  4. Drive from Knoxville to Great Smoky Mountains

$71 - $143

Drive  •  9 h 43 min

  1. Drive from St. Louis to Great Smoky Mountains 552.4 miles

$50 - $80

Questions & Answers

The cheapest way to get from St. Louis to Great Smoky Mountains is to drive which costs $50 - $80 and takes 9 h 43 min.

More details

The quickest way to get from St. Louis to Great Smoky Mountains is to fly and drive which takes 7 h 14 min and costs $200 - $1,200.

More details

The distance between St. Louis and Great Smoky Mountains is 683 km. The road distance is 884 km.

Get driving directions

It takes approximately 7 h 14 min to get from St. Louis to Great Smoky Mountains, including transfers.

More details

What companies run services between St. Louis, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from St. Louis to Great Smoky Mountains. However, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Knoxville via Charlotte
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$230 - $1,100
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 18 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Knoxville via Reagan Washington
Ave. Duration
5 h 20 min
When
Every day
Estimated price
$260 - $1,200
Flights from St. Louis to Knoxville via Philadelphia
Ave. Duration
5 h 39 min
When
Saturday
Estimated price
$280 - $1,200
Flights from St. Louis to Asheville via Charlotte
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via Dallas/Ft.Worth
Ave. Duration
5 h 44 min
When
Saturday
Estimated price
$290 - $1,200
Flights from St. Louis to Greenville/Spartanburg via Charlotte
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Philadelphia
Ave. Duration
4 h 54 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 59 min
When
Sunday
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Dallas/Ft.Worth
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$290 - $450
Delta
Website
delta.com
Flights from St. Louis to Knoxville via Atlanta
Ave. Duration
4 h 29 min
When
Every day
Estimated price
$200 - $1,100
Flights from St. Louis to Knoxville via Detroit
Ave. Duration
4 h 41 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via Atlanta
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$210 - $1,100
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$300 - $460
Flights from St. Louis to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 43 min
When
Every day
Estimated price
$300 - $460
United Airlines
Website
united.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 56 min
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Knoxville via Washington Dulles
Ave. Duration
5 h
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Asheville via Chicago O'Hare
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Newark
Ave. Duration
6 h
When
Every day
Estimated price
$300 - $1,300
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$320 - $490
Flights from St. Louis to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 57 min
When
Every day
Estimated price
$320 - $490
Flights from St. Louis to Greenville/Spartanburg via Houston
Ave. Duration
5 h 25 min
When
Every day
Estimated price
$320 - $490
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
5 h
When
Every day
Estimated price
$200 - $900
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 40 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Nashville, TN to Chattanooga
Ave. Duration
2 h 37 min
Frequency
Twice daily
Estimated price
$14 - $25
Schedules at
us.megabus.com
Bus from Chattanooga to Knoxville
Ave. Duration
2 h
Frequency
Twice daily
Estimated price
$12 - $22
Schedules at
us.megabus.com

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