There are 5 ways to get from St. Louis to Great Smoky Mountains by plane, car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

What companies run services between St. Louis, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from St. Louis to Great Smoky Mountains. However, you can take the train to St. Louis airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the train to St. Louis airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Avg. Duration
4 h 1 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Charlotte
Avg. Duration
4 h 57 min
When
Every day
Estimated price
$230 - $1,100
Flights from St. Louis to Knoxville via Reagan Washington
Avg. Duration
4 h 41 min
When
Sunday
Estimated price
$260 - $1,200
Flights from St. Louis to Knoxville via Dallas/Ft.Worth
Avg. Duration
4 h 47 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Knoxville via Philadelphia
Avg. Duration
5 h 14 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Asheville via Charlotte
Avg. Duration
4 h 24 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via Dallas/Ft.Worth
Avg. Duration
5 h 22 min
When
Saturday
Estimated price
$290 - $1,200
Flights from St. Louis to Asheville via Chicago O'Hare, Charlotte
Avg. Duration
6 h 11 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from St. Louis to Greenville/Spartanburg via Charlotte
Avg. Duration
4 h 22 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Reagan Washington
Avg. Duration
4 h 34 min
When
Sunday
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Avg. Duration
4 h 49 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Philadelphia
Avg. Duration
5 h 18 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Dallas/Ft.Worth
Avg. Duration
5 h 36 min
When
Monday, Tuesday, Thursday, Friday, Saturday and Sunday
Estimated price
$290 - $450
Delta
Website
delta.com
Flights from St. Louis to Knoxville via Atlanta
Avg. Duration
4 h
When
Every day
Estimated price
$200 - $1,100
Flights from St. Louis to Knoxville via Detroit
Avg. Duration
4 h 24 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via Atlanta
Avg. Duration
4 h 3 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,100
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Avg. Duration
3 h 58 min
When
Every day
Estimated price
$300 - $460
Flights from St. Louis to Greenville/Spartanburg via Detroit
Avg. Duration
4 h 36 min
When
Monday to Saturday
Estimated price
$300 - $460
Flights from St. Louis to Greenville/Spartanburg via New York La Guardia
Avg. Duration
5 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $460
United Airlines
Website
united.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Avg. Duration
4 h 40 min
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Knoxville via Washington Dulles
Avg. Duration
5 h 3 min
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Knoxville via Houston
Avg. Duration
5 h 52 min
When
Every day
Estimated price
$290 - $1,300
Flights from St. Louis to Asheville via Chicago O'Hare
Avg. Duration
4 h 13 min
When
Every day
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Newark
Avg. Duration
6 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $1,300
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Avg. Duration
4 h 37 min
When
Every day
Estimated price
$320 - $490
Flights from St. Louis to Greenville/Spartanburg via Washington Dulles
Avg. Duration
4 h 53 min
When
Every day
Estimated price
$320 - $490
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Avg. Duration
5 h
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $900
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St. Louis, MO to Nashville, TN
Avg. Duration
6 h 40 min
Frequency
4 times a day
Estimated price
$35 - $85
Website
greyhound.com
Rome2rio guide to
rome2rio.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Nashville, TN to Knoxville, TN
Avg. Duration
3 h 33 min
Frequency
3 times a day
Estimated price
$23 - $55
Website
greyhound.com
Rome2rio guide to
rome2rio.com
Economy
$23 - $35
Flexible
$40 - $55

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Questions & Answers

How far is it from St. Louis to Great Smoky Mountains?

The distance between St. Louis and Great Smoky Mountains is 683 km. The road distance is 884 km.

What is the cheapest way to get from St. Louis to Great Smoky Mountains?

The cheapest way to get from St. Louis to Great Smoky Mountains is to drive which costs $65 and takes 9 h 43 min.

What is the fastest way to get from St. Louis to Great Smoky Mountains?

The quickest way to get from St. Louis to Great Smoky Mountains is to fly and drive which takes 6 h 44 min and costs $550.

How long does it take to get from St. Louis to Great Smoky Mountains?

It takes approximately 6 h 44 min to get from St. Louis to Great Smoky Mountains, including transfers.