There are 6 ways to get from La Crosse to Chicago by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Chicago O'Hare  •  2 h 9 min

  1. Fly from La Crosse (LSE) to Chicago O'Hare (ORD) LSE - ORD

$166 - $671

Cheapest option

Train  •  5 h 8 min

  1. Take the train from La Crosse Amtrak to Chicago Union Station Empire Builder

$50 - $130

4 alternative options

Fly to Chicago Midway  •  4 h 50 min

  1. Fly from La Crosse (LSE) to Chicago Midway (MDW) LSE - MDW

$226 - $1,120

Bus Jefferson Lines  •  6 h 30 min

  1. Take the bus from La Crosse to Milwaukee 965
  2. Take the bus from Milwaukee, Wi to Chicago, Il 4727 / ...

$59 - $95

Bus Vangalder Bus  •  7 h

  1. Take the bus from La Crosse, WI - UW La Crosse - Sanford Hall to Madison, WI - Chazen UW Madison College Connection
  2. Take the bus from Madison, WI-Langdon & Park St to Chicago, IL - Amtrak

$68

Drive  •  4 h 44 min

  1. Drive from La Crosse to Chicago 284.4 miles

$27 - $40

Questions & Answers

The cheapest way to get from La Crosse to Chicago is to drive which costs $27 - $40 and takes 4 h 44 min.

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The quickest way to get from La Crosse to Chicago is to fly which costs $160 - $700 and takes 2 h 9 min.

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No, there is no direct bus from La Crosse to Chicago. However, there are services departing from La Crosse and arriving at Chicago, Il via Milwaukee, Wi. The journey, including transfers, takes approximately 6 h 30 min.

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Yes, there is a direct train departing from La Crosse Amtrak and arriving at Chicago Union Station station. Services depart three times a day, and operate every day. The journey takes approximately 5 h 8 min.

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The distance between La Crosse and Chicago is 228 miles. The road distance is 284.4 miles.

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The best way to get from La Crosse to Chicago without a car is to train which takes 5 h 8 min and costs $50 - $130.

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It takes approximately 2 h 9 min to get from La Crosse to Chicago, including transfers.

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La Crosse to Chicago bus services, operated by Jefferson Lines, depart from La Crosse station.

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La Crosse to Chicago train services, operated by Amtrak, depart from La Crosse Amtrak station.

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The best way to get from La Crosse to Chicago is to fly which takes 2 h 9 min and costs $160 - $700. Alternatively, you can train, which costs $50 - $130 and takes 5 h 8 min, you could also bus, which costs $55 - $100 and takes 6 h 30 min.

Mode details

Map of how to get from La Crosse to Chicago.
Launch map view
  • Distance: 227.5 miles
  • Duration: 2 h 9 min

What companies run services between La Crosse, WI, USA and Chicago, IL, USA?

American Airlines flies from La Crosse to Chicago 3 times a day. Alternatively, Amtrak operates a train from La Crosse to Chicago 3 times a day. Tickets cost $50 - $130 and the journey takes 5 h 8 min.

Airlines
Delta
Website
delta.com
Flights from La Crosse to Chicago Midway via Minneapolis
Ave. Duration
5 h 18 min
When
Every day
Estimated price
$210 - $1,100
Flights from La Crosse to Chicago Midway via Minneapolis, Detroit
Ave. Duration
6 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from La Crosse to Chicago Midway via Minneapolis, Atlanta
Ave. Duration
9 h 5 min
When
Every day
Estimated price
$320 - $1,400
American Airlines
Website
aa.com
Flights from La Crosse to Chicago O'Hare
Ave. Duration
1 h 12 min
When
Every day
Estimated price
$260 - $850
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from La Crosse Amtrak to Chicago Union Station
Ave. Duration
5 h 8 min
Frequency
3 times a day
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from La Crosse to Milwaukee
Ave. Duration
4 h 20 min
Frequency
Every 3 hours
Estimated price
$40 - $65
Book at
jeffersonlines.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to Chicago, Il
Ave. Duration
1 h 55 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Badger Bus
Website
badgerbus.com
Bus from La Crosse, WI - UW La Crosse - Sanford Hall to Madison, WI - Chazen UW Madison
Ave. Duration
2 h 45 min
Frequency
Every 4 hours
Estimated price
$38
Schedules at
badgerbus.com
Book at
badgerbus.com
Vangalder Bus
Phone
+1 608-752-5407
Email
vangalder@coachusa.com
Bus from Madison, WI-Langdon & Park St to Chicago, IL - Amtrak
Ave. Duration
3 h 15 min
Frequency
Hourly
Estimated price
$30
Schedules at
vangalderbus.com
Book at
govangalder.com

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from La Crosse Airport to Chicago O'Hare Airport is the direct flight which takes 1 h 10 min.

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La Crosse to Chicago bus services, operated by Greyhound USA, arrive at Chicago, Il station.

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La Crosse to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.

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Yes, the driving distance between La Crosse to Chicago is 284 miles. It takes approximately 4 h 44 min to drive from La Crosse to Chicago.

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American Airlines offers flights from La Crosse Airport to Chicago O'Hare Airport.

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Book your La Crosse to Chicago train tickets online with Rome2rio.

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There are 574+ hotels available in Chicago. Prices start at $104 USD per night.

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The best way to get from La Crosse to La Crosse Airport is to taxi which takes 11 min and costs $13 - $17.

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