The average train between Slough and Preston takes 3h 38m and the fastest train takes 2h 59m. There is a train service every few hours from Slough to Preston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Slough and Preston. The earliest departure is at 6:21 AM in the morning, and the last departure from Slough is at 11:21 PM which arrives into Preston at 8:35 AM. All services require a transfer at Tottenham Court Road Station and take an average of 3h 38m. The schedules shown below are for the next available departures.


3h 1m • 2 changes


2h 59m • 2 changes


3h 17m • 2 changes


3h 15m • 2 changes


3h 2m • 2 changes


3h 3m • 2 changes


3h 2m • 2 changes


3h • 2 changes


3h 2m • 2 changes


3h 3m • 2 changes


3h 2m • 2 changes


3h • 2 changes
Want to know about travelling from Slough to Preston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Slough to Preston. However, there are services departing from Slough station and arriving at Preston station via Tottenham Court Rd. The journey, including transfers, takes approximately 3h 38m.
Slough to Preston train services, operated by Elizabeth Line (TfL), depart from Slough station.
Slough to Preston train services, operated by Elizabeth Line (TfL), arrive at Preston station.
Book your Slough to Preston train tickets online with Elizabeth Line (TfL), London Underground (Tube) and 2 other operators.
The distance between Slough and Preston is 288.1 km. The road distance is 369 km.
You can take a train from Slough to Preston via Tottenham Court Road Station, Tottenham Court Road station, Euston station, and London Euston in around 3h 17m.