The average train between Slough and Hamilton takes 5h 57m and the fastest train takes 5h 7m. The train service runs several times per day from Slough to Hamilton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Slough and Hamilton. The earliest departure is at 7:21 AM in the morning, and the last departure from Slough is at 11:19 PM which arrives into Hamilton at 1:50 PM. All services require a transfer at Tottenham Court Road Station and take an average of 5h 57m. The schedules shown below are for the next available departures.


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Want to know about travelling from Slough to Hamilton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Slough to Hamilton. However, there are services departing from Slough station and arriving at Hamilton station via Motherwell. The journey, including transfers, takes approximately 5h 57m.
Slough to Hamilton train services, operated by Elizabeth Line (TfL), depart from London Euston station.
Slough to Hamilton train services, operated by Elizabeth Line (TfL), arrive at Motherwell station.
Book your Slough to Hamilton train tickets online with Elizabeth Line (TfL), London Underground (Tube) and 2 other operators.
The distance between Slough and Hamilton is 524.7 km. The road distance is 656 km.
Avanti West Coast operates a train from London Euston to Motherwell every 3 hours. Tickets cost £130–230 and the journey takes 4h 17m. Caledonian Sleeper also services this route 5 times a week.