Train Sistine Chapel to Pisa from €52 | Tickets & Timetables

Trip Overview

The average train between Sistine Chapel and Pisa takes 3h 19m and the fastest train takes 2h 30m. The train service runs several times per day from Sistine Chapel to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 19m
Duration: 341 km
Distance: €52
Average price: Every 2 hours
Frequency

Train via Rome Termini (Trenitalia)

best

Take the train from Roma Termini to Pisa Centraletrain Fa / ...

3h 26m

€36–102

Sistine Chapel to Pisa train times

Trains run every 2 hours between Sistine Chapel and Pisa. The earliest departure is at 6:06 AM in the morning, and the last departure from Sistine Chapel is at 8:09 PM which arrives into Pisa at 10:40 PM. All services require a transfer at Ottaviano and take an average of 3h 19m. The schedules shown below are for the next available departures.

Departing Wednesday, June 3, 2026

6:09 AM → 8:45 AM
2h 35m • 1 change
6:26 AM → 9:41 AM
3h 14m • 1 change
9:43 AM → 1:44 PM
4h • 1 change
9:58 AM → 2:35 PM
4h 36m • 1 change
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Departing Thursday, June 4, 2026

6:09 AM → 8:45 AM
2h 35m • 1 change
6:26 AM → 9:41 AM
3h 14m • 1 change
9:43 AM → 1:44 PM
4h • 1 change
9:58 AM → 2:35 PM
4h 36m • 1 change
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Departing Friday, June 5, 2026

6:09 AM → 8:45 AM
2h 35m • 1 change
6:26 AM → 9:41 AM
3h 14m • 1 change
9:43 AM → 1:44 PM
4h • 1 change
9:58 AM → 2:35 PM
4h 36m • 1 change
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Departing Saturday, June 6, 2026

6:06 AM → 8:45 AM
2h 38m • 1 change
6:44 AM → 9:43 AM
2h 58m • 1 change
9:58 AM → 2:15 PM
4h 16m • 1 change
11:43 AM → 2:49 PM
3h 5m • 1 change
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Departing Sunday, June 7, 2026

6:07 AM → 8:45 AM
2h 37m • 1 change
6:43 AM → 9:43 AM
2h 59m • 1 change
9:42 AM → 12:59 PM
3h 16m • 1 change
9:52 AM → 2:15 PM
4h 22m • 1 change
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Frequently asked questions

Want to know about travelling from Sistine Chapel to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Sistine Chapel to Pisa.

Launch map view

Distance: 341.3 km
Duration: 3h 19m

What companies run services between Sistine Chapel, Vatican City and Pisa, Italy?

Trenitalia Frecce operates a train from Roma Termini to Pisa Centrale every 4 hours. Tickets cost €50–100 and the journey takes 2h 22m. Two other operators also service this route.

Operators