The average train between Siena and Prague takes 22h 41m and the fastest train takes 21h 5m. The train service runs several times per day from Siena to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Siena and Prague. The earliest departure is at 12:18 PM in the afternoon, and the last departure from Siena is at 9:40 PM which arrives into Prague at 9:58 PM. All services require a transfer at Firenze S.M.N. and take an average of 22h 41m. The schedules shown below are for the next available departures.
Arrives next day



21h 5m • 3 changes
Arrives next day



24h 18m • 3 changes
Arrives next day



21h 5m • 3 changes
Arrives next day



24h 18m • 3 changes
Arrives next day



21h 5m • 3 changes
Arrives next day



24h 18m • 3 changes
Want to know about travelling from Siena to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena to Prague. However, there are services departing from Siena station and arriving at Prague station via Firenze S.M.N.. The journey, including transfers, takes approximately 22h 41m.
Siena to Prague train services, operated by Trenitalia, depart from Siena station.
Siena to Prague train services, operated by Trenitalia, arrive at Praha Hlavni Nadrazi station.
Book your Siena to Prague train tickets online with Trenitalia, Trenitalia Frecce and 2 other operators.
The distance between Siena and Prague is 788.6 km. The road distance is 1,415 km.
You can take a train from Siena to Praha Hlavni Nadrazi via Firenze S.M.N., Venezia Mestre, and Wien Hbf in around 16h 48m.