The average train between Siena and Brno takes 19h 57m and the fastest train takes 18h 23m. The train service runs several times per day from Siena to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Siena and Brno. The earliest departure is at 12:18 PM in the afternoon, and the last departure from Siena is at 9:40 PM which arrives into Brno at 7:12 PM. All services require a transfer at Firenze S.M.N. and take an average of 19h 57m. The schedules shown below are for the next available departures.
Arrives next day



18h 23m • 3 changes
Arrives next day



21h 32m • 3 changes
Arrives next day



18h 23m • 3 changes
Arrives next day



21h 32m • 3 changes
Arrives next day



18h 23m • 3 changes
Arrives next day



21h 32m • 3 changes
Arrives next day



18h 23m • 3 changes
Arrives next day



21h 32m • 3 changes
Want to know about travelling from Siena to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena to Brno. However, there are services departing from Siena station and arriving at Brno station via Firenze S.M.N.. The journey, including transfers, takes approximately 19h 57m.
Siena to Brno train services, operated by Trenitalia, depart from Siena station.
Siena to Brno train services, operated by Trenitalia, arrive at Brno Hlavni Nadrazi station.
Book your Siena to Brno train tickets online with Trenitalia, Trenitalia Frecce and 2 other operators.
The distance between Siena and Brno is 768.8 km. The road distance is 1,163 km.
You can take a train from Siena to Brno Hlavni Nadrazi via Firenze S.M.N., Venezia Mestre, and Wien Hbf in around 14h 1m.