The average train between Santander and Cuenca takes 7h 27m and the fastest train takes 5h 34m. The train service runs several times per day from Santander to Cuenca. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Santander and Cuenca. The earliest departure is at 6:48 AM in the morning, and the last departure from Santander is at 7:00 PM which arrives into Cuenca at 7:17 AM. All services require a transfer, and take on average 7h 27m. The schedules shown below are for the next available departures.

6h 7m • 1 change

5h 34m • 1 change
Arrives next day

12h 17m • 1 change

6h 7m • 1 change

5h 34m • 1 change

6h 2m • 1 change
Arrives next day

12h 17m • 1 change

6h 7m • 1 change

5h 34m • 1 change
Arrives next day

12h 17m • 1 change

6h 7m • 1 change

5h 34m • 1 change
Arrives next day

12h 17m • 1 change
Want to know about travelling from Santander to Cuenca? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santander to Cuenca. However, there are services departing from Santander station and arriving at Cuenca station via Madrid Chamartín. The journey, including transfers, takes approximately 7h 27m.
Santander to Cuenca train services, operated by Renfe Viajeros, depart from Santander station.
Santander to Cuenca train services, operated by Renfe Viajeros, arrive at Cuenca Fernando Zobel station.
Book your Santander to Cuenca train tickets online with Renfe Viajeros.
The distance between Santander and Cuenca is 402.4 km. The road distance is 636 km.
You can take a train from Santander to Cuenca Fernando Zobel via Madrid Chamartín in around 5h 43m.